Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations
Abstract Background Concurrent variation in adiposity and inflammation suggests potential shared functional pathways and pleiotropic disease underpinning. Yet, exploration of pleiotropy in the context of adiposity-inflammation has been scarce, and none has included self-identified Hispanic/Latino po...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-09-01
|
| Series: | BMC Medical Genomics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12920-022-01352-3 |
| _version_ | 1811211799015456768 |
|---|---|
| author | Mohammad Yaser Anwar Antoine R. Baldassari Hannah G. Polikowsky Colleen M. Sitlani Heather M. Highland Nathalie Chami Hung-Hsin Chen Mariaelisa Graff Annie Green Howard Su Yon Jung Lauren E. Petty Zhe Wang Wanying Zhu Steven Buyske Iona Cheng Robert Kaplan Charles Kooperberg Ruth J. F. Loos Ulrike Peters Joseph B. McCormick Susan P. Fisher-Hoch Christy L. Avery Kira C. Taylor Jennifer E. Below Kari E. North |
| author_facet | Mohammad Yaser Anwar Antoine R. Baldassari Hannah G. Polikowsky Colleen M. Sitlani Heather M. Highland Nathalie Chami Hung-Hsin Chen Mariaelisa Graff Annie Green Howard Su Yon Jung Lauren E. Petty Zhe Wang Wanying Zhu Steven Buyske Iona Cheng Robert Kaplan Charles Kooperberg Ruth J. F. Loos Ulrike Peters Joseph B. McCormick Susan P. Fisher-Hoch Christy L. Avery Kira C. Taylor Jennifer E. Below Kari E. North |
| author_sort | Mohammad Yaser Anwar |
| collection | DOAJ |
| description | Abstract Background Concurrent variation in adiposity and inflammation suggests potential shared functional pathways and pleiotropic disease underpinning. Yet, exploration of pleiotropy in the context of adiposity-inflammation has been scarce, and none has included self-identified Hispanic/Latino populations. Given the high level of ancestral diversity in Hispanic American population, genetic studies may reveal variants that are infrequent/monomorphic in more homogeneous populations. Methods Using multi-trait Adaptive Sum of Powered Score (aSPU) method, we examined individual and shared genetic effects underlying inflammatory (CRP) and adiposity-related traits (Body Mass Index [BMI]), and central adiposity (Waist to Hip Ratio [WHR]) in HLA participating in the Population Architecture Using Genomics and Epidemiology (PAGE) cohort (N = 35,871) with replication of effects in the Cameron County Hispanic Cohort (CCHC) which consists of Mexican American individuals. Results Of the > 16 million SNPs tested, variants representing 7 independent loci were found to illustrate significant association with multiple traits. Two out of 7 variants were replicated at statistically significant level in multi-trait analyses in CCHC. The lead variant on APOE (rs439401) and rs11208712 were found to harbor multi-trait associations with adiposity and inflammation. Conclusions Results from this study demonstrate the importance of considering pleiotropy for improving our understanding of the etiology of the various metabolic pathways that regulate cardiovascular disease development. |
| first_indexed | 2024-04-12T05:19:17Z |
| format | Article |
| id | doaj.art-7729e5f05bc64483af0e6d8c690b8ff2 |
| institution | Directory Open Access Journal |
| issn | 1755-8794 |
| language | English |
| last_indexed | 2024-04-12T05:19:17Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genomics |
| spelling | doaj.art-7729e5f05bc64483af0e6d8c690b8ff22022-12-22T03:46:33ZengBMCBMC Medical Genomics1755-87942022-09-0115111110.1186/s12920-022-01352-3Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populationsMohammad Yaser Anwar0Antoine R. Baldassari1Hannah G. Polikowsky2Colleen M. Sitlani3Heather M. Highland4Nathalie Chami5Hung-Hsin Chen6Mariaelisa Graff7Annie Green Howard8Su Yon Jung9Lauren E. Petty10Zhe Wang11Wanying Zhu12Steven Buyske13Iona Cheng14Robert Kaplan15Charles Kooperberg16Ruth J. F. Loos17Ulrike Peters18Joseph B. McCormick19Susan P. Fisher-Hoch20Christy L. Avery21Kira C. Taylor22Jennifer E. Below23Kari E. North24Department of Epidemiology, University of North Carolina at Chapel HillDepartment of Epidemiology, University of North Carolina at Chapel HillVanderbilt Genetics Institute, Vanderbilt University Medical CenterDepartment of Medicine, University of WashingtonDepartment of Epidemiology, University of North Carolina at Chapel HillThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount SinaiVanderbilt Genetics Institute, Vanderbilt University Medical CenterDepartment of Epidemiology, University of North Carolina at Chapel HillDepartment of Biostatistics, University of North Carolina at Chapel HillTranslational Sciences Section, School of Nursing, University of California, Los AngelesVanderbilt Genetics Institute, Vanderbilt University Medical CenterThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount SinaiVanderbilt Genetics Institute, Vanderbilt University Medical CenterDepartment of Statistics, Rutgers UniversityDepartment of Epidemiology and Biostatistics, Helen Diller Family Comprehensive Cancer Center, University of California San FranciscoAlbert Einstein College of MedicineDivision of Public Health Sciences, Fred Hutchinson Cancer CenterThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount SinaiDivision of Public Health Sciences, Fred Hutchinson Cancer CenterSchool of Public Health, University of Texas Health Science Center at HoustonSchool of Public Health, University of Texas Health Science Center at HoustonDepartment of Epidemiology, University of North Carolina at Chapel HillDepartment of Epidemiology and Population Health, University of Louisville School of Public Health and Information SciencesVanderbilt Genetics Institute, Vanderbilt University Medical CenterDepartment of Epidemiology, University of North Carolina at Chapel HillAbstract Background Concurrent variation in adiposity and inflammation suggests potential shared functional pathways and pleiotropic disease underpinning. Yet, exploration of pleiotropy in the context of adiposity-inflammation has been scarce, and none has included self-identified Hispanic/Latino populations. Given the high level of ancestral diversity in Hispanic American population, genetic studies may reveal variants that are infrequent/monomorphic in more homogeneous populations. Methods Using multi-trait Adaptive Sum of Powered Score (aSPU) method, we examined individual and shared genetic effects underlying inflammatory (CRP) and adiposity-related traits (Body Mass Index [BMI]), and central adiposity (Waist to Hip Ratio [WHR]) in HLA participating in the Population Architecture Using Genomics and Epidemiology (PAGE) cohort (N = 35,871) with replication of effects in the Cameron County Hispanic Cohort (CCHC) which consists of Mexican American individuals. Results Of the > 16 million SNPs tested, variants representing 7 independent loci were found to illustrate significant association with multiple traits. Two out of 7 variants were replicated at statistically significant level in multi-trait analyses in CCHC. The lead variant on APOE (rs439401) and rs11208712 were found to harbor multi-trait associations with adiposity and inflammation. Conclusions Results from this study demonstrate the importance of considering pleiotropy for improving our understanding of the etiology of the various metabolic pathways that regulate cardiovascular disease development.https://doi.org/10.1186/s12920-022-01352-3ObesityInflammationGenetic pleiotropyHispanic Americans |
| spellingShingle | Mohammad Yaser Anwar Antoine R. Baldassari Hannah G. Polikowsky Colleen M. Sitlani Heather M. Highland Nathalie Chami Hung-Hsin Chen Mariaelisa Graff Annie Green Howard Su Yon Jung Lauren E. Petty Zhe Wang Wanying Zhu Steven Buyske Iona Cheng Robert Kaplan Charles Kooperberg Ruth J. F. Loos Ulrike Peters Joseph B. McCormick Susan P. Fisher-Hoch Christy L. Avery Kira C. Taylor Jennifer E. Below Kari E. North Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations BMC Medical Genomics Obesity Inflammation Genetic pleiotropy Hispanic Americans |
| title | Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations |
| title_full | Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations |
| title_fullStr | Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations |
| title_full_unstemmed | Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations |
| title_short | Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations |
| title_sort | genetic pleiotropy underpinning adiposity and inflammation in self identified hispanic latino populations |
| topic | Obesity Inflammation Genetic pleiotropy Hispanic Americans |
| url | https://doi.org/10.1186/s12920-022-01352-3 |
| work_keys_str_mv | AT mohammadyaseranwar geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT antoinerbaldassari geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT hannahgpolikowsky geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT colleenmsitlani geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT heathermhighland geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT nathaliechami geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT hunghsinchen geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT mariaelisagraff geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT anniegreenhoward geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT suyonjung geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT laurenepetty geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT zhewang geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT wanyingzhu geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT stevenbuyske geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT ionacheng geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT robertkaplan geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT charleskooperberg geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT ruthjfloos geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT ulrikepeters geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT josephbmccormick geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT susanpfisherhoch geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT christylavery geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT kiractaylor geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT jenniferebelow geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations AT karienorth geneticpleiotropyunderpinningadiposityandinflammationinselfidentifiedhispaniclatinopopulations |