First Report on the <i>Streptococcus</i> <i>gallolyticus</i> (<i>S. bovis</i> Biotype I) DSM 13808 Exopolysaccharide Structure
<i>Streptococcus gallolyticus</i> subspecies <i>gallolyticus</i>, known as <i>Streptococcus bovis</i> biotype I, is a facultative pathogen causing bacteraemia, infective endocarditis and sepsis that has been linked with colorectal cancer (CRC), but this correlatio...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/19/11797 |
| Summary: | <i>Streptococcus gallolyticus</i> subspecies <i>gallolyticus</i>, known as <i>Streptococcus bovis</i> biotype I, is a facultative pathogen causing bacteraemia, infective endocarditis and sepsis that has been linked with colorectal cancer (CRC), but this correlation is still unclear. Bacterial surface structures, such as the major sugar antigens exposed to the outside of the microorganism, are potential virulence factors. One of the primary sugar antigens loosely attached to the cell surface is the biofilm component, exopolysaccharide (EPS). EPSs of <i>S. bovis</i> are poorly characterized molecules. Until now, only one <i>S. macedonicus</i> Sc136 EPS structure was known to the entire <i>S. bovis</i> group. The <i>S. gallolyticus</i> DSM 13808 EPS was investigated by chemical analysis, mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. The hexasaccharide repeating unit of the EPS, containing four Glc, two Rha residues and one phosphate group, has been described “ →6)-α-<span style="font-variant: small-caps;">d</span>-Glc<i>p</i>-(1→3)-β-<span style="font-variant: small-caps;">l</span>-Rha<i>p</i>-(1→4)-β-<span style="font-variant: small-caps;">d</span>-Glc<i>p</i>-(1→3)-[β-<span style="font-variant: small-caps;">d</span>-Glc<i>p</i>-(1→2)]-α-<span style="font-variant: small-caps;">l</span>-Rha<i>p</i>-(1→2)-α-<span style="font-variant: small-caps;">d</span>-Glc<i>p</i>-(1→P→”. |
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| ISSN: | 1661-6596 1422-0067 |