Impact of nonsurgical and antibiotics treatment on periodontitis
Background: Periodontitis is one of the most prevalent chronic inflammatory noncommunicable and multifactorial diseases. Objectives: The present study was aimed to detect the effect of systemic antibiotics as disjunctive to nonsurgical treatment of generalized periodontitis (grade I and grade II) on...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Medical Journal of Babylon |
| Subjects: | |
| Online Access: | http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2023;volume=20;issue=3;spage=486;epage=490;aulast=Imran |
| _version_ | 1797645434969128960 |
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| author | Azhar Abdullah Imran Zeyad Nazar M Al-Talib Fatima Al-Rubea Malik |
| author_facet | Azhar Abdullah Imran Zeyad Nazar M Al-Talib Fatima Al-Rubea Malik |
| author_sort | Azhar Abdullah Imran |
| collection | DOAJ |
| description | Background: Periodontitis is one of the most prevalent chronic inflammatory noncommunicable and multifactorial diseases. Objectives: The present study was aimed to detect the effect of systemic antibiotics as disjunctive to nonsurgical treatment of generalized periodontitis (grade I and grade II) on the bacterial count and clinical periodontal parameters. Materials and Methods: Subgingival plaque samples were collected from 40 patients with generalized periodontitis, 20 patients were treated with scaling and root planning only, and 20 patients were treated with a combination of ciprofloxacin 500 mg and metronidazole 500 mg with scaling and root planning. Moreover, 20 samples were collected from healthy patients as a control group. Specific periodontal pathogen genes for Tannerella forsythia (BspA, CIpB genes) were identified using real time polymerase reaction (RT-PCR). Results: In this study, 120 samples were detected for the presence of T. forsythia by RT-PCR technique, and the specific ClpB, and BspA primers’ genes were used for the amplification of a fragment of these genes for the identification of T. forsythia. The results showed that the presence of ClpB and BspA in all (100%). BspA and ClpB showed a decrease but non-significant differences before and after treatment, whereas the periodontal parameter, probing pocket depth, plaque score, and bleeding on probing showed a significant decrease after treatment except clinical attachment lose showing a non-significant difference. Conclusion: Clinical treatment (scaling and root planning) is often helpful in the treatment of generalized periodontal disease (grade I and grade II) without the need for antimicrobial therapy as soon as possible. |
| first_indexed | 2024-03-11T14:46:19Z |
| format | Article |
| id | doaj.art-772aa5bc9e26433ba4f041bb93fe22ef |
| institution | Directory Open Access Journal |
| issn | 1812-156X 2312-6760 |
| language | English |
| last_indexed | 2024-03-11T14:46:19Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Babylon |
| spelling | doaj.art-772aa5bc9e26433ba4f041bb93fe22ef2023-10-30T11:05:10ZengWolters Kluwer Medknow PublicationsMedical Journal of Babylon1812-156X2312-67602023-01-0120348649010.4103/MJBL.MJBL_99_23Impact of nonsurgical and antibiotics treatment on periodontitisAzhar Abdullah ImranZeyad Nazar M Al-TalibFatima Al-Rubea MalikBackground: Periodontitis is one of the most prevalent chronic inflammatory noncommunicable and multifactorial diseases. Objectives: The present study was aimed to detect the effect of systemic antibiotics as disjunctive to nonsurgical treatment of generalized periodontitis (grade I and grade II) on the bacterial count and clinical periodontal parameters. Materials and Methods: Subgingival plaque samples were collected from 40 patients with generalized periodontitis, 20 patients were treated with scaling and root planning only, and 20 patients were treated with a combination of ciprofloxacin 500 mg and metronidazole 500 mg with scaling and root planning. Moreover, 20 samples were collected from healthy patients as a control group. Specific periodontal pathogen genes for Tannerella forsythia (BspA, CIpB genes) were identified using real time polymerase reaction (RT-PCR). Results: In this study, 120 samples were detected for the presence of T. forsythia by RT-PCR technique, and the specific ClpB, and BspA primers’ genes were used for the amplification of a fragment of these genes for the identification of T. forsythia. The results showed that the presence of ClpB and BspA in all (100%). BspA and ClpB showed a decrease but non-significant differences before and after treatment, whereas the periodontal parameter, probing pocket depth, plaque score, and bleeding on probing showed a significant decrease after treatment except clinical attachment lose showing a non-significant difference. Conclusion: Clinical treatment (scaling and root planning) is often helpful in the treatment of generalized periodontal disease (grade I and grade II) without the need for antimicrobial therapy as soon as possible.http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2023;volume=20;issue=3;spage=486;epage=490;aulast=Imranantibioticnonsurgical treatmentperiodontitisrt-pcrtannerella forsythia |
| spellingShingle | Azhar Abdullah Imran Zeyad Nazar M Al-Talib Fatima Al-Rubea Malik Impact of nonsurgical and antibiotics treatment on periodontitis Medical Journal of Babylon antibiotic nonsurgical treatment periodontitis rt-pcr tannerella forsythia |
| title | Impact of nonsurgical and antibiotics treatment on periodontitis |
| title_full | Impact of nonsurgical and antibiotics treatment on periodontitis |
| title_fullStr | Impact of nonsurgical and antibiotics treatment on periodontitis |
| title_full_unstemmed | Impact of nonsurgical and antibiotics treatment on periodontitis |
| title_short | Impact of nonsurgical and antibiotics treatment on periodontitis |
| title_sort | impact of nonsurgical and antibiotics treatment on periodontitis |
| topic | antibiotic nonsurgical treatment periodontitis rt-pcr tannerella forsythia |
| url | http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2023;volume=20;issue=3;spage=486;epage=490;aulast=Imran |
| work_keys_str_mv | AT azharabdullahimran impactofnonsurgicalandantibioticstreatmentonperiodontitis AT zeyadnazarmaltalib impactofnonsurgicalandantibioticstreatmentonperiodontitis AT fatimaalrubeamalik impactofnonsurgicalandantibioticstreatmentonperiodontitis |