Relationship Between Docetaxel AUC and Neutropenia in Patients with Breast Cancer
Objective To investigate the relationship between docetaxel AUC(area under curve) and neutropenia in patients with breast cancer after chemotherapy. Methods We selected 94 patients with breast cancer who accepted AC sequential T chemotherapy regimen as the first-line treatment from December 2016 to...
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2018-05-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://html.rhhz.net/ZLFZYJ/html/8578.2018.17.1459.htm |
| _version_ | 1818847718984908800 |
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| author | ZHANG Ni TIAN Fengqi HE Baoxia |
| author_facet | ZHANG Ni TIAN Fengqi HE Baoxia |
| author_sort | ZHANG Ni |
| collection | DOAJ |
| description | Objective To investigate the relationship between docetaxel AUC(area under curve) and neutropenia in patients with breast cancer after chemotherapy. Methods We selected 94 patients with breast cancer who accepted AC sequential T chemotherapy regimen as the first-line treatment from December 2016 to July 2017 in the Affiliated Cancer Hospital of Zhengzhou University. The plasma concentration of docetaxel was detected by latex immunoturbidimetry after the docetaxel continuous infusion. Docetaxel AUC was calculated using nonparametric mixed-effects models. A mathematical model predicting decreased percentage of neutrophils using docetaxel AUC was established. Results Individual exposure to docetaxel was highly variable (AUC range=0.7-3.9 mg·h/L, mean value=(2.34±0.7)mg·h/L, inter-individual CV=30%). The average AUC for low (0-2) and high grade (3-4) neutropenia were 2.29 and 2.82 mg·h/L, respectively(P=0.003). The model predicting decreased percentage of neutrophils using docetaxel AUC was set as y=-1.8672x2+25.658x-14.92, r=0.643. Conclusion This research set up a mathematical model to predict decreased percentage of neutrophil, which provide basis for screening high-risk patients who may suffer seriously hematological toxicity and lay a theoretical foundation for individualized dosage based on docetaxel AUC. |
| first_indexed | 2024-12-19T06:05:55Z |
| format | Article |
| id | doaj.art-772c78e6cb0d450b855994df77e92594 |
| institution | Directory Open Access Journal |
| issn | 1000-8578 1000-8578 |
| language | zho |
| last_indexed | 2024-12-19T06:05:55Z |
| publishDate | 2018-05-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-772c78e6cb0d450b855994df77e925942022-12-21T20:33:08ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782018-05-0145528528810.3971/j.issn.1000-8578.2018.17.14598578.2018.17.1459Relationship Between Docetaxel AUC and Neutropenia in Patients with Breast CancerZHANG Ni0TIAN Fengqi1HE Baoxia2Department of Pharmacy, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, ChinaDepartment of Pharmacy, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, ChinaDepartment of Pharmacy, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, ChinaObjective To investigate the relationship between docetaxel AUC(area under curve) and neutropenia in patients with breast cancer after chemotherapy. Methods We selected 94 patients with breast cancer who accepted AC sequential T chemotherapy regimen as the first-line treatment from December 2016 to July 2017 in the Affiliated Cancer Hospital of Zhengzhou University. The plasma concentration of docetaxel was detected by latex immunoturbidimetry after the docetaxel continuous infusion. Docetaxel AUC was calculated using nonparametric mixed-effects models. A mathematical model predicting decreased percentage of neutrophils using docetaxel AUC was established. Results Individual exposure to docetaxel was highly variable (AUC range=0.7-3.9 mg·h/L, mean value=(2.34±0.7)mg·h/L, inter-individual CV=30%). The average AUC for low (0-2) and high grade (3-4) neutropenia were 2.29 and 2.82 mg·h/L, respectively(P=0.003). The model predicting decreased percentage of neutrophils using docetaxel AUC was set as y=-1.8672x2+25.658x-14.92, r=0.643. Conclusion This research set up a mathematical model to predict decreased percentage of neutrophil, which provide basis for screening high-risk patients who may suffer seriously hematological toxicity and lay a theoretical foundation for individualized dosage based on docetaxel AUC.http://html.rhhz.net/ZLFZYJ/html/8578.2018.17.1459.htmdocetaxelbreast canceraucneutropenia |
| spellingShingle | ZHANG Ni TIAN Fengqi HE Baoxia Relationship Between Docetaxel AUC and Neutropenia in Patients with Breast Cancer Zhongliu Fangzhi Yanjiu docetaxel breast cancer auc neutropenia |
| title | Relationship Between Docetaxel AUC and Neutropenia in Patients with Breast Cancer |
| title_full | Relationship Between Docetaxel AUC and Neutropenia in Patients with Breast Cancer |
| title_fullStr | Relationship Between Docetaxel AUC and Neutropenia in Patients with Breast Cancer |
| title_full_unstemmed | Relationship Between Docetaxel AUC and Neutropenia in Patients with Breast Cancer |
| title_short | Relationship Between Docetaxel AUC and Neutropenia in Patients with Breast Cancer |
| title_sort | relationship between docetaxel auc and neutropenia in patients with breast cancer |
| topic | docetaxel breast cancer auc neutropenia |
| url | http://html.rhhz.net/ZLFZYJ/html/8578.2018.17.1459.htm |
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