An Overview of the Curcumin-Based and Allicin Bioactive Compounds as potential treatment to SARS-CoV-2 with structural bioinformatics tools
The recent outbreak of SARS-CoV-2 across the globe and the absence of a specific cure against the disease lead the scientific community to investigate some alternative indigenous treatments. SARS-CoV-2 is the virus responsible for the coronavirus ailment 2019 (COVID-19). This virus has 4 auxiliary p...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Indonesian |
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Poltekkes Kemenkes Yogyakarta
2021-11-01
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| Series: | Jurnal Teknologi Laboratorium |
| Subjects: | |
| Online Access: | https://www.teknolabjournal.com/index.php/Jtl/article/view/291 |
| _version_ | 1797818574337736704 |
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| author | Axel Fortunio Shiloputra Arli Aditya Parikesit Jeremie Theddy Darmawan Viona Pricillia Dora Dayu Rahma Turista Arif Nur Muhammad Ansori |
| author_facet | Axel Fortunio Shiloputra Arli Aditya Parikesit Jeremie Theddy Darmawan Viona Pricillia Dora Dayu Rahma Turista Arif Nur Muhammad Ansori |
| author_sort | Axel Fortunio Shiloputra |
| collection | DOAJ |
| description | The recent outbreak of SARS-CoV-2 across the globe and the absence of a specific cure against the disease lead the scientific community to investigate some alternative indigenous treatments. SARS-CoV-2 is the virus responsible for the coronavirus ailment 2019 (COVID-19). This virus has 4 auxiliary proteins namely the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins. The main proteases and RNA dependent RNA polymerase are also essential structures by which the virus replicates and survives. Each of these proteins are structures of the virus that are potential targets for drugs which are leads in the drug discovery process of any drug for the virus. Currently available treatments are not specific to the disease and therefore carry unwanted adverse effects that can be highly dangerous and sometimes fatal. Many of these treatments are supplementary in nature or based on repurposed drugs from other viral outbreaks. Alternatives of conventional drugs are required to control the spread and severity of the disease. Allicin, curcumin and their derivatives have been researched for their antiviral property and shown to have good binding affinity towards SARS-CoV-2 structures essential in their survival, especially the main proteases and RNA dependent RNA polymerases. The structural bioinformatics tools have elicited methods to predict the bioactivity of the natural product-based compounds. Apart from the beneficial medication that they offer, natural products carry along other advantages for the current pandemic situation in terms of supply, logistics, and affordability. |
| first_indexed | 2024-03-13T09:09:55Z |
| format | Article |
| id | doaj.art-772cc7eda6194465a3311a2257c6dca2 |
| institution | Directory Open Access Journal |
| issn | 2338-5634 2580-0191 |
| language | Indonesian |
| last_indexed | 2024-03-13T09:09:55Z |
| publishDate | 2021-11-01 |
| publisher | Poltekkes Kemenkes Yogyakarta |
| record_format | Article |
| series | Jurnal Teknologi Laboratorium |
| spelling | doaj.art-772cc7eda6194465a3311a2257c6dca22023-05-27T07:07:06ZindPoltekkes Kemenkes YogyakartaJurnal Teknologi Laboratorium2338-56342580-01912021-11-01102596710.29238/teknolabjournal.v10i2.291244An Overview of the Curcumin-Based and Allicin Bioactive Compounds as potential treatment to SARS-CoV-2 with structural bioinformatics toolsAxel Fortunio Shiloputra0Arli Aditya Parikesit1Jeremie Theddy Darmawan2Viona Pricillia3Dora Dayu Rahma Turista4Arif Nur Muhammad Ansori5Indonesia International Institute for Life SciencesIndonesia International Institute for Life SciencesIndonesia International Institute for Life SciencesIndonesia International Institute for Life SciencesMulawarman UniversityUniversitas AirlanggaThe recent outbreak of SARS-CoV-2 across the globe and the absence of a specific cure against the disease lead the scientific community to investigate some alternative indigenous treatments. SARS-CoV-2 is the virus responsible for the coronavirus ailment 2019 (COVID-19). This virus has 4 auxiliary proteins namely the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins. The main proteases and RNA dependent RNA polymerase are also essential structures by which the virus replicates and survives. Each of these proteins are structures of the virus that are potential targets for drugs which are leads in the drug discovery process of any drug for the virus. Currently available treatments are not specific to the disease and therefore carry unwanted adverse effects that can be highly dangerous and sometimes fatal. Many of these treatments are supplementary in nature or based on repurposed drugs from other viral outbreaks. Alternatives of conventional drugs are required to control the spread and severity of the disease. Allicin, curcumin and their derivatives have been researched for their antiviral property and shown to have good binding affinity towards SARS-CoV-2 structures essential in their survival, especially the main proteases and RNA dependent RNA polymerases. The structural bioinformatics tools have elicited methods to predict the bioactivity of the natural product-based compounds. Apart from the beneficial medication that they offer, natural products carry along other advantages for the current pandemic situation in terms of supply, logistics, and affordability.https://www.teknolabjournal.com/index.php/Jtl/article/view/291bioactive compoundscoronaviruscovid-19in silicosars-cov-2 |
| spellingShingle | Axel Fortunio Shiloputra Arli Aditya Parikesit Jeremie Theddy Darmawan Viona Pricillia Dora Dayu Rahma Turista Arif Nur Muhammad Ansori An Overview of the Curcumin-Based and Allicin Bioactive Compounds as potential treatment to SARS-CoV-2 with structural bioinformatics tools Jurnal Teknologi Laboratorium bioactive compounds coronavirus covid-19 in silico sars-cov-2 |
| title | An Overview of the Curcumin-Based and Allicin Bioactive Compounds as potential treatment to SARS-CoV-2 with structural bioinformatics tools |
| title_full | An Overview of the Curcumin-Based and Allicin Bioactive Compounds as potential treatment to SARS-CoV-2 with structural bioinformatics tools |
| title_fullStr | An Overview of the Curcumin-Based and Allicin Bioactive Compounds as potential treatment to SARS-CoV-2 with structural bioinformatics tools |
| title_full_unstemmed | An Overview of the Curcumin-Based and Allicin Bioactive Compounds as potential treatment to SARS-CoV-2 with structural bioinformatics tools |
| title_short | An Overview of the Curcumin-Based and Allicin Bioactive Compounds as potential treatment to SARS-CoV-2 with structural bioinformatics tools |
| title_sort | overview of the curcumin based and allicin bioactive compounds as potential treatment to sars cov 2 with structural bioinformatics tools |
| topic | bioactive compounds coronavirus covid-19 in silico sars-cov-2 |
| url | https://www.teknolabjournal.com/index.php/Jtl/article/view/291 |
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