Defensins and cystein rich peptides: two types of antimicrobial peptides in marine molluscs
This review focuses on defensins and cystein rich peptides, which are the most abundant natural antimicrobial peptides (AMPs) described in molluscs. These are compact peptides, 3-5 kDa in molecular mass, cationic and amphipatic; the presence of at least six cysteine residues forming three or four di...
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| Format: | Article |
| Language: | English |
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University of Modena and Reggio Emilia
2010-06-01
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| Series: | Invertebrate Survival Journal |
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| Online Access: | https://isj02.unimore.it/index.php/ISJ/article/view/218 |
| _version_ | 1818881714629378048 |
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| author | G Arenas Díaz |
| author_facet | G Arenas Díaz |
| author_sort | G Arenas Díaz |
| collection | DOAJ |
| description | This review focuses on defensins and cystein rich peptides, which are the most abundant natural antimicrobial peptides (AMPs) described in molluscs. These are compact peptides, 3-5 kDa in molecular mass, cationic and amphipatic; the presence of at least six cysteine residues forming three or four disulfide bridges is their prime structural characteristic. A 3-D structural characterization of these molecules has been included in recent investigations, using currently-available techniques. AMPs have been purified from hemocytes, epithelial tissue and plasma as well as cloned and chemically synthesized. Their antibacterial activity against Gram-positive and Gram-negative bacteria and fungi has been shown; only a synthetic mytilin fragment has displayed activity against viruses. |
| first_indexed | 2024-12-19T15:06:15Z |
| format | Article |
| id | doaj.art-772da1bf3ebf4e618c788e9dcfa61570 |
| institution | Directory Open Access Journal |
| issn | 1824-307X |
| language | English |
| last_indexed | 2024-12-19T15:06:15Z |
| publishDate | 2010-06-01 |
| publisher | University of Modena and Reggio Emilia |
| record_format | Article |
| series | Invertebrate Survival Journal |
| spelling | doaj.art-772da1bf3ebf4e618c788e9dcfa615702022-12-21T20:16:26ZengUniversity of Modena and Reggio EmiliaInvertebrate Survival Journal1824-307X2010-06-0172Defensins and cystein rich peptides: two types of antimicrobial peptides in marine molluscsG Arenas Díaz0Laboratorio de Genética e Inmunología Molecular, Instituto de Biología, Campus Curauma, Pontificia Universidad Católica de Valparaíso, ChileThis review focuses on defensins and cystein rich peptides, which are the most abundant natural antimicrobial peptides (AMPs) described in molluscs. These are compact peptides, 3-5 kDa in molecular mass, cationic and amphipatic; the presence of at least six cysteine residues forming three or four disulfide bridges is their prime structural characteristic. A 3-D structural characterization of these molecules has been included in recent investigations, using currently-available techniques. AMPs have been purified from hemocytes, epithelial tissue and plasma as well as cloned and chemically synthesized. Their antibacterial activity against Gram-positive and Gram-negative bacteria and fungi has been shown; only a synthetic mytilin fragment has displayed activity against viruses.https://isj02.unimore.it/index.php/ISJ/article/view/218defensinscystein rich peptidesantimicrobial peptidesinnate immunitymarine molluscs |
| spellingShingle | G Arenas Díaz Defensins and cystein rich peptides: two types of antimicrobial peptides in marine molluscs Invertebrate Survival Journal defensins cystein rich peptides antimicrobial peptides innate immunity marine molluscs |
| title | Defensins and cystein rich peptides: two types of antimicrobial peptides in marine molluscs |
| title_full | Defensins and cystein rich peptides: two types of antimicrobial peptides in marine molluscs |
| title_fullStr | Defensins and cystein rich peptides: two types of antimicrobial peptides in marine molluscs |
| title_full_unstemmed | Defensins and cystein rich peptides: two types of antimicrobial peptides in marine molluscs |
| title_short | Defensins and cystein rich peptides: two types of antimicrobial peptides in marine molluscs |
| title_sort | defensins and cystein rich peptides two types of antimicrobial peptides in marine molluscs |
| topic | defensins cystein rich peptides antimicrobial peptides innate immunity marine molluscs |
| url | https://isj02.unimore.it/index.php/ISJ/article/view/218 |
| work_keys_str_mv | AT garenasdiaz defensinsandcysteinrichpeptidestwotypesofantimicrobialpeptidesinmarinemolluscs |