Postsynaptic Proteins at Excitatory Synapses in the Brain—Relationship with Depressive Disorders
Depressive disorders (DDs) are an increasingly common health problem that affects all age groups. DDs pathogenesis is multifactorial. However, it was proven that stress is one of the most important environmental factors contributing to the development of these conditions. In recent years, there has...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/19/11423 |
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| author | Sylwia Samojedny Ewelina Czechowska Patrycja Pańczyszyn-Trzewik Magdalena Sowa-Kućma |
| author_facet | Sylwia Samojedny Ewelina Czechowska Patrycja Pańczyszyn-Trzewik Magdalena Sowa-Kućma |
| author_sort | Sylwia Samojedny |
| collection | DOAJ |
| description | Depressive disorders (DDs) are an increasingly common health problem that affects all age groups. DDs pathogenesis is multifactorial. However, it was proven that stress is one of the most important environmental factors contributing to the development of these conditions. In recent years, there has been growing interest in the role of the glutamatergic system in the context of pharmacotherapy of DDs. Thus, it has become increasingly important to explore the functioning of excitatory synapses in pathogenesis and pharmacological treatment of psychiatric disorders (including DDs). This knowledge may lead to the description of new mechanisms of depression and indicate new potential targets for the pharmacotherapy of illness. An excitatory synapse is a highly complex and very dynamic structure, containing a vast number of proteins. This review aimed to discuss in detail the role of the key postsynaptic proteins (e.g., NMDAR, AMPAR, mGluR5, PSD-95, Homer, NOS etc.) in the excitatory synapse and to systematize the knowledge about changes that occur in the clinical course of depression and after antidepressant treatment. In addition, a discussion on the potential use of ligands and/or modulators of postsynaptic proteins at the excitatory synapse has been presented. |
| first_indexed | 2024-03-09T21:40:13Z |
| format | Article |
| id | doaj.art-772e6a797e7e4334adbae6f98396994b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:40:13Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-772e6a797e7e4334adbae6f98396994b2023-11-23T20:32:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-0123191142310.3390/ijms231911423Postsynaptic Proteins at Excitatory Synapses in the Brain—Relationship with Depressive DisordersSylwia Samojedny0Ewelina Czechowska1Patrycja Pańczyszyn-Trzewik2Magdalena Sowa-Kućma3Students Science Club “NEURON”, Medical College of Rzeszów University, Kopisto 2a, 35-315 Rzeszow, PolandDepartment of Human Physiology, Institute of Medical Sciences, Medical College of Rzeszów University, Kopisto 2a, 35-315 Rzeszów, PolandDepartment of Human Physiology, Institute of Medical Sciences, Medical College of Rzeszów University, Kopisto 2a, 35-315 Rzeszów, PolandDepartment of Human Physiology, Institute of Medical Sciences, Medical College of Rzeszów University, Kopisto 2a, 35-315 Rzeszów, PolandDepressive disorders (DDs) are an increasingly common health problem that affects all age groups. DDs pathogenesis is multifactorial. However, it was proven that stress is one of the most important environmental factors contributing to the development of these conditions. In recent years, there has been growing interest in the role of the glutamatergic system in the context of pharmacotherapy of DDs. Thus, it has become increasingly important to explore the functioning of excitatory synapses in pathogenesis and pharmacological treatment of psychiatric disorders (including DDs). This knowledge may lead to the description of new mechanisms of depression and indicate new potential targets for the pharmacotherapy of illness. An excitatory synapse is a highly complex and very dynamic structure, containing a vast number of proteins. This review aimed to discuss in detail the role of the key postsynaptic proteins (e.g., NMDAR, AMPAR, mGluR5, PSD-95, Homer, NOS etc.) in the excitatory synapse and to systematize the knowledge about changes that occur in the clinical course of depression and after antidepressant treatment. In addition, a discussion on the potential use of ligands and/or modulators of postsynaptic proteins at the excitatory synapse has been presented.https://www.mdpi.com/1422-0067/23/19/11423PSD proteinsAMPARNMDARmGluR5NOSHomer |
| spellingShingle | Sylwia Samojedny Ewelina Czechowska Patrycja Pańczyszyn-Trzewik Magdalena Sowa-Kućma Postsynaptic Proteins at Excitatory Synapses in the Brain—Relationship with Depressive Disorders International Journal of Molecular Sciences PSD proteins AMPAR NMDAR mGluR5 NOS Homer |
| title | Postsynaptic Proteins at Excitatory Synapses in the Brain—Relationship with Depressive Disorders |
| title_full | Postsynaptic Proteins at Excitatory Synapses in the Brain—Relationship with Depressive Disorders |
| title_fullStr | Postsynaptic Proteins at Excitatory Synapses in the Brain—Relationship with Depressive Disorders |
| title_full_unstemmed | Postsynaptic Proteins at Excitatory Synapses in the Brain—Relationship with Depressive Disorders |
| title_short | Postsynaptic Proteins at Excitatory Synapses in the Brain—Relationship with Depressive Disorders |
| title_sort | postsynaptic proteins at excitatory synapses in the brain relationship with depressive disorders |
| topic | PSD proteins AMPAR NMDAR mGluR5 NOS Homer |
| url | https://www.mdpi.com/1422-0067/23/19/11423 |
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