Improvements in Gut Microbiome Composition Predict the Clinical Efficacy of a Novel Synbiotics Formula in Children with Mild to Moderate Atopic Dermatitis
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a significant association with various type-2 inflammation-related comorbidities. Ongoing research suggests the crucial involvement of gut microbiome, especially in childhood onset AD, and hence, probiotics have emerged as a p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/11/9/2175 |
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| author | Chi Tung Choy Pui Ling Kella Siu Junwei Zhou Chi Ho Wong Yuk Wai Lee Ho Wang Chan Joseph Chi Ching Tsui Claudia Jun Yi Lo Steven King Fan Loo Stephen Kwok Wing Tsui |
| author_facet | Chi Tung Choy Pui Ling Kella Siu Junwei Zhou Chi Ho Wong Yuk Wai Lee Ho Wang Chan Joseph Chi Ching Tsui Claudia Jun Yi Lo Steven King Fan Loo Stephen Kwok Wing Tsui |
| author_sort | Chi Tung Choy |
| collection | DOAJ |
| description | Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a significant association with various type-2 inflammation-related comorbidities. Ongoing research suggests the crucial involvement of gut microbiome, especially in childhood onset AD, and hence, probiotics have emerged as a potential non-steroid-based therapeutics option to complement existing AD management plans. In order to delineate the impact of probiotics in the gut microbiome of pediatric AD patients from southern China, targeted 16S rRNA sequencing and thorough bioinformatic analysis were performed to analyze the gut microbiome profiles of 24 AD children after taking an orally administered novel synbiotics formula with triple prebiotics for 8 weeks. A notable improvement in Eczema Area and Severity Index (EASI) (<i>p</i> = 0.008) was observed after taking an 8-week course of probiotics, with no adverse effects observed. The relative abundances of key microbial drivers including <i>Bacteroides fragilis</i> and <i>Lactobacillus acidophilus</i> were significantly increased at week 8. We also found that the positive responsiveness towards an 8-week course of probiotics was associated with improvements in the gut microbiome profile with a higher relative abundance of probiotic species. Over-represented functional abundance pathways related to vitamin B synthesis and peptidoglycan recycling may imply the underlying mechanism. In summary, our study suggests how the gut microbial landscape shifts upon probiotic supplementation in AD children, and provides preliminary evidence to support targeted probiotic supplementation for the management of childhood AD. |
| first_indexed | 2024-03-10T22:27:04Z |
| format | Article |
| id | doaj.art-772ed72cd5e94761834ec368b28050bd |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T22:27:04Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-772ed72cd5e94761834ec368b28050bd2023-11-19T12:01:37ZengMDPI AGMicroorganisms2076-26072023-08-01119217510.3390/microorganisms11092175Improvements in Gut Microbiome Composition Predict the Clinical Efficacy of a Novel Synbiotics Formula in Children with Mild to Moderate Atopic DermatitisChi Tung Choy0Pui Ling Kella Siu1Junwei Zhou2Chi Ho Wong3Yuk Wai Lee4Ho Wang Chan5Joseph Chi Ching Tsui6Claudia Jun Yi Lo7Steven King Fan Loo8Stephen Kwok Wing Tsui9Microbiome Research Centre, BioMed Laboratory Company Limited, Hong KongMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong KongMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong KongMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong KongMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong KongMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong KongMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong KongMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong KongMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong KongMicrobiome Research Centre, BioMed Laboratory Company Limited, Hong KongAtopic dermatitis (AD) is a common chronic inflammatory skin disease with a significant association with various type-2 inflammation-related comorbidities. Ongoing research suggests the crucial involvement of gut microbiome, especially in childhood onset AD, and hence, probiotics have emerged as a potential non-steroid-based therapeutics option to complement existing AD management plans. In order to delineate the impact of probiotics in the gut microbiome of pediatric AD patients from southern China, targeted 16S rRNA sequencing and thorough bioinformatic analysis were performed to analyze the gut microbiome profiles of 24 AD children after taking an orally administered novel synbiotics formula with triple prebiotics for 8 weeks. A notable improvement in Eczema Area and Severity Index (EASI) (<i>p</i> = 0.008) was observed after taking an 8-week course of probiotics, with no adverse effects observed. The relative abundances of key microbial drivers including <i>Bacteroides fragilis</i> and <i>Lactobacillus acidophilus</i> were significantly increased at week 8. We also found that the positive responsiveness towards an 8-week course of probiotics was associated with improvements in the gut microbiome profile with a higher relative abundance of probiotic species. Over-represented functional abundance pathways related to vitamin B synthesis and peptidoglycan recycling may imply the underlying mechanism. In summary, our study suggests how the gut microbial landscape shifts upon probiotic supplementation in AD children, and provides preliminary evidence to support targeted probiotic supplementation for the management of childhood AD.https://www.mdpi.com/2076-2607/11/9/2175atopic dermatitisgut microbiomeprobiotics |
| spellingShingle | Chi Tung Choy Pui Ling Kella Siu Junwei Zhou Chi Ho Wong Yuk Wai Lee Ho Wang Chan Joseph Chi Ching Tsui Claudia Jun Yi Lo Steven King Fan Loo Stephen Kwok Wing Tsui Improvements in Gut Microbiome Composition Predict the Clinical Efficacy of a Novel Synbiotics Formula in Children with Mild to Moderate Atopic Dermatitis Microorganisms atopic dermatitis gut microbiome probiotics |
| title | Improvements in Gut Microbiome Composition Predict the Clinical Efficacy of a Novel Synbiotics Formula in Children with Mild to Moderate Atopic Dermatitis |
| title_full | Improvements in Gut Microbiome Composition Predict the Clinical Efficacy of a Novel Synbiotics Formula in Children with Mild to Moderate Atopic Dermatitis |
| title_fullStr | Improvements in Gut Microbiome Composition Predict the Clinical Efficacy of a Novel Synbiotics Formula in Children with Mild to Moderate Atopic Dermatitis |
| title_full_unstemmed | Improvements in Gut Microbiome Composition Predict the Clinical Efficacy of a Novel Synbiotics Formula in Children with Mild to Moderate Atopic Dermatitis |
| title_short | Improvements in Gut Microbiome Composition Predict the Clinical Efficacy of a Novel Synbiotics Formula in Children with Mild to Moderate Atopic Dermatitis |
| title_sort | improvements in gut microbiome composition predict the clinical efficacy of a novel synbiotics formula in children with mild to moderate atopic dermatitis |
| topic | atopic dermatitis gut microbiome probiotics |
| url | https://www.mdpi.com/2076-2607/11/9/2175 |
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