Rewiring of Cancer Cell Metabolism by Mitochondrial VDAC1 Depletion Results in Time-Dependent Tumor Reprogramming: Glioblastoma as a Proof of Concept

Rewiring of Cancer Cell Metabolism by Mitochondrial VDAC1 Depletion Results in Time-Dependent Tumor Reprogramming: Glioblastoma as a Proof of Concept

Reprograming of the metabolism of cancer cells is an event recognized as a hallmark of the disease. The mitochondrial gatekeeper, voltage-dependent anion channel 1 (VDAC1), mediates transport of metabolites and ions in and out of mitochondria, and is involved in mitochondria-mediated apoptosis. Here...

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Bibliographic Details
Main Authors: Tasleem Arif, Oriel Stern, Srinivas Pittala, Vered Chalifa-Caspi, Varda Shoshan-Barmatz
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
cancer stem cells
differentiation
glioblastoma
mitochondria
si-rna
tspo
vdac1
Online Access:https://www.mdpi.com/2073-4409/8/11/1330

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