Design, Preparation and In Vitro Evaluation of Core–Shell Fused Deposition Modelling 3D-Printed Verapamil Hydrochloride Pulsatile Tablets
The aim of the study was to investigate core–shell pulsatile tablets by combining the advantages of FDM 3D printing and traditional pharmaceutical technology, which are suitable for a patient’s individual medication and chronopathology. The tablets were designed and prepared with the commercial vera...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/2/437 |
| _version_ | 1797477184800030720 |
|---|---|
| author | Rui Li Yue Pan Di Chen Xiangyu Xu Guangrong Yan Tianyuan Fan |
| author_facet | Rui Li Yue Pan Di Chen Xiangyu Xu Guangrong Yan Tianyuan Fan |
| author_sort | Rui Li |
| collection | DOAJ |
| description | The aim of the study was to investigate core–shell pulsatile tablets by combining the advantages of FDM 3D printing and traditional pharmaceutical technology, which are suitable for a patient’s individual medication and chronopathology. The tablets were designed and prepared with the commercial verapamil hydrochloride tablets as core inside and the fused deposition modelling (FDM) 3D-printed shell outside. Filaments composed of hydroxypropylmethyl cellulose (HPMC) and polyethylenglycol (PEG) 400 were prepared by hot melt extrusion (HME) and used for fabrication of the shell. Seven types of printed shells were designed for the tablets by adjusting the filament composition, geometric structure and thickness of the shell. A series of evaluations were then performed on the 3D-printed core–shell tablets, including the morphology, weight, hardness, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), X-ray powder diffraction (XRD), in vitro drug release and CT imaging. The results showed that the tablets prepared by FDM 3D printing appeared intact without any defects. All the excipients of the tablet shells were thermally stable during the extruding and printing process. The weight, hardness and in vitro drug release of the tablets were affected by the filament composition, geometric structure and thickness of the shell. The pulsatile tablets achieved personalized lag time ranging from 4 h to 8 h in the drug release test in phosphate-buffered solution (pH 6.8). Therefore, the 3D-printed core–shell pulsatile tablets in this study presented good potential in personalized administration, thereby improving the therapeutic effects of the drug for circadian rhythm disease. |
| first_indexed | 2024-03-09T21:14:03Z |
| format | Article |
| id | doaj.art-77308c51baa9428ea3a25f59761215be |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T21:14:03Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-77308c51baa9428ea3a25f59761215be2023-11-23T21:39:20ZengMDPI AGPharmaceutics1999-49232022-02-0114243710.3390/pharmaceutics14020437Design, Preparation and In Vitro Evaluation of Core–Shell Fused Deposition Modelling 3D-Printed Verapamil Hydrochloride Pulsatile TabletsRui Li0Yue Pan1Di Chen2Xiangyu Xu3Guangrong Yan4Tianyuan Fan5The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, ChinaThe State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, ChinaThe State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, ChinaSchool of Mechanical Engineering and Automation, Beihang University, Beijing 100191, ChinaSchool of Mechanical Engineering and Automation, Beihang University, Beijing 100191, ChinaThe State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, ChinaThe aim of the study was to investigate core–shell pulsatile tablets by combining the advantages of FDM 3D printing and traditional pharmaceutical technology, which are suitable for a patient’s individual medication and chronopathology. The tablets were designed and prepared with the commercial verapamil hydrochloride tablets as core inside and the fused deposition modelling (FDM) 3D-printed shell outside. Filaments composed of hydroxypropylmethyl cellulose (HPMC) and polyethylenglycol (PEG) 400 were prepared by hot melt extrusion (HME) and used for fabrication of the shell. Seven types of printed shells were designed for the tablets by adjusting the filament composition, geometric structure and thickness of the shell. A series of evaluations were then performed on the 3D-printed core–shell tablets, including the morphology, weight, hardness, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), X-ray powder diffraction (XRD), in vitro drug release and CT imaging. The results showed that the tablets prepared by FDM 3D printing appeared intact without any defects. All the excipients of the tablet shells were thermally stable during the extruding and printing process. The weight, hardness and in vitro drug release of the tablets were affected by the filament composition, geometric structure and thickness of the shell. The pulsatile tablets achieved personalized lag time ranging from 4 h to 8 h in the drug release test in phosphate-buffered solution (pH 6.8). Therefore, the 3D-printed core–shell pulsatile tablets in this study presented good potential in personalized administration, thereby improving the therapeutic effects of the drug for circadian rhythm disease.https://www.mdpi.com/1999-4923/14/2/437FDM 3D printingoral pulsatile tabletsverapamil hydrochloridepersonalization |
| spellingShingle | Rui Li Yue Pan Di Chen Xiangyu Xu Guangrong Yan Tianyuan Fan Design, Preparation and In Vitro Evaluation of Core–Shell Fused Deposition Modelling 3D-Printed Verapamil Hydrochloride Pulsatile Tablets Pharmaceutics FDM 3D printing oral pulsatile tablets verapamil hydrochloride personalization |
| title | Design, Preparation and In Vitro Evaluation of Core–Shell Fused Deposition Modelling 3D-Printed Verapamil Hydrochloride Pulsatile Tablets |
| title_full | Design, Preparation and In Vitro Evaluation of Core–Shell Fused Deposition Modelling 3D-Printed Verapamil Hydrochloride Pulsatile Tablets |
| title_fullStr | Design, Preparation and In Vitro Evaluation of Core–Shell Fused Deposition Modelling 3D-Printed Verapamil Hydrochloride Pulsatile Tablets |
| title_full_unstemmed | Design, Preparation and In Vitro Evaluation of Core–Shell Fused Deposition Modelling 3D-Printed Verapamil Hydrochloride Pulsatile Tablets |
| title_short | Design, Preparation and In Vitro Evaluation of Core–Shell Fused Deposition Modelling 3D-Printed Verapamil Hydrochloride Pulsatile Tablets |
| title_sort | design preparation and in vitro evaluation of core shell fused deposition modelling 3d printed verapamil hydrochloride pulsatile tablets |
| topic | FDM 3D printing oral pulsatile tablets verapamil hydrochloride personalization |
| url | https://www.mdpi.com/1999-4923/14/2/437 |
| work_keys_str_mv | AT ruili designpreparationandinvitroevaluationofcoreshellfuseddepositionmodelling3dprintedverapamilhydrochloridepulsatiletablets AT yuepan designpreparationandinvitroevaluationofcoreshellfuseddepositionmodelling3dprintedverapamilhydrochloridepulsatiletablets AT dichen designpreparationandinvitroevaluationofcoreshellfuseddepositionmodelling3dprintedverapamilhydrochloridepulsatiletablets AT xiangyuxu designpreparationandinvitroevaluationofcoreshellfuseddepositionmodelling3dprintedverapamilhydrochloridepulsatiletablets AT guangrongyan designpreparationandinvitroevaluationofcoreshellfuseddepositionmodelling3dprintedverapamilhydrochloridepulsatiletablets AT tianyuanfan designpreparationandinvitroevaluationofcoreshellfuseddepositionmodelling3dprintedverapamilhydrochloridepulsatiletablets |