Inter-ankle Systolic Blood Pressure Difference Is a Marker of Increased Fasting Blood-Glucose in Asian Pregnant Women
ObjectiveThis cross-sectional study aimed to determine the relationship between clinical blood pressures and blood pressures measured using Doppler with blood glucose in pregnancy by ethnicity.MethodsWe recruited 179 (52% White European, 48% Asian) pregnant women at 24-28 weeks of gestation who unde...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-05-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.842254/full |
| _version_ | 1818243081294577664 |
|---|---|
| author | Ruo Zhang Hema Viswambharan Chew Weng Cheng Malgorzata Anna Garstka Kirti Kain |
| author_facet | Ruo Zhang Hema Viswambharan Chew Weng Cheng Malgorzata Anna Garstka Kirti Kain |
| author_sort | Ruo Zhang |
| collection | DOAJ |
| description | ObjectiveThis cross-sectional study aimed to determine the relationship between clinical blood pressures and blood pressures measured using Doppler with blood glucose in pregnancy by ethnicity.MethodsWe recruited 179 (52% White European, 48% Asian) pregnant women at 24-28 weeks of gestation who underwent a glucose tolerance test in an antenatal clinic in Bradford Royal Infirmary, the UK, from 2012 to 2013. Systolic blood pressures in the arm (left and right brachial) and ankle [left and right posterior tibial (PT) and dorsalis pedalis (DP)] blood pressures were measured using a Doppler probe. The inter-arm (brachial) and inter-ankle (PT and DP) systolic blood pressure differences were obtained. A multivariate linear regression model adjusted for age, body mass index, and diabetes risk was used to assess the relationship between blood pressures and blood glucose.ResultsAsian pregnant women had higher blood glucose but lower ankle blood pressures than White Europeans. In White Europeans, brachial blood pressures and clinical blood pressures were positively associated with fasting blood glucose (FBG), but brachial blood pressures did not perform better as an indicator of FBG than clinical blood pressures. In Asians, increased inter-ankle blood pressure difference was associated with increased FBG. For each 10 mmHg increase in the inter-ankle blood pressure difference, FBG increased by 0.12 mmol/L (Beta=0.12, 95%CI: 0.01-0.23).ConclusionThe relationship between blood pressures with blood glucose differed by ethnicity. In Asians, inter-ankle systolic blood pressure difference was positively associated with blood glucose. This is first ever report on ankle blood pressures with blood glucose in pregnancy which suggests future potential as a non-invasive gestational diabetes risk screening tool. |
| first_indexed | 2024-12-12T13:55:27Z |
| format | Article |
| id | doaj.art-773280249c40465eaf634151a698cc34 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-12T13:55:27Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-773280249c40465eaf634151a698cc342022-12-22T00:22:28ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-05-011310.3389/fendo.2022.842254842254Inter-ankle Systolic Blood Pressure Difference Is a Marker of Increased Fasting Blood-Glucose in Asian Pregnant WomenRuo Zhang0Hema Viswambharan1Chew Weng Cheng2Malgorzata Anna Garstka3Kirti Kain4Department of Endocrinology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United KingdomLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United KingdomCore Research Laboratory, Department of Endocrinology, Department of Tumor and Immunology, Precision Medical Institute, Western China Science and Technology Innovation Port, The Second Affiliated Hospital, Health Science Center, Xi’an Jiaotong University, Xi’an, ChinaNHS England & NHS Improvement (North East and Yorkshire), Leeds, United KingdomObjectiveThis cross-sectional study aimed to determine the relationship between clinical blood pressures and blood pressures measured using Doppler with blood glucose in pregnancy by ethnicity.MethodsWe recruited 179 (52% White European, 48% Asian) pregnant women at 24-28 weeks of gestation who underwent a glucose tolerance test in an antenatal clinic in Bradford Royal Infirmary, the UK, from 2012 to 2013. Systolic blood pressures in the arm (left and right brachial) and ankle [left and right posterior tibial (PT) and dorsalis pedalis (DP)] blood pressures were measured using a Doppler probe. The inter-arm (brachial) and inter-ankle (PT and DP) systolic blood pressure differences were obtained. A multivariate linear regression model adjusted for age, body mass index, and diabetes risk was used to assess the relationship between blood pressures and blood glucose.ResultsAsian pregnant women had higher blood glucose but lower ankle blood pressures than White Europeans. In White Europeans, brachial blood pressures and clinical blood pressures were positively associated with fasting blood glucose (FBG), but brachial blood pressures did not perform better as an indicator of FBG than clinical blood pressures. In Asians, increased inter-ankle blood pressure difference was associated with increased FBG. For each 10 mmHg increase in the inter-ankle blood pressure difference, FBG increased by 0.12 mmol/L (Beta=0.12, 95%CI: 0.01-0.23).ConclusionThe relationship between blood pressures with blood glucose differed by ethnicity. In Asians, inter-ankle systolic blood pressure difference was positively associated with blood glucose. This is first ever report on ankle blood pressures with blood glucose in pregnancy which suggests future potential as a non-invasive gestational diabetes risk screening tool.https://www.frontiersin.org/articles/10.3389/fendo.2022.842254/fullankle blood pressuredopplerclinical blood pressureglucose metabolismOGTT (oral glucose tolerance test)pregnancy |
| spellingShingle | Ruo Zhang Hema Viswambharan Chew Weng Cheng Malgorzata Anna Garstka Kirti Kain Inter-ankle Systolic Blood Pressure Difference Is a Marker of Increased Fasting Blood-Glucose in Asian Pregnant Women Frontiers in Endocrinology ankle blood pressure doppler clinical blood pressure glucose metabolism OGTT (oral glucose tolerance test) pregnancy |
| title | Inter-ankle Systolic Blood Pressure Difference Is a Marker of Increased Fasting Blood-Glucose in Asian Pregnant Women |
| title_full | Inter-ankle Systolic Blood Pressure Difference Is a Marker of Increased Fasting Blood-Glucose in Asian Pregnant Women |
| title_fullStr | Inter-ankle Systolic Blood Pressure Difference Is a Marker of Increased Fasting Blood-Glucose in Asian Pregnant Women |
| title_full_unstemmed | Inter-ankle Systolic Blood Pressure Difference Is a Marker of Increased Fasting Blood-Glucose in Asian Pregnant Women |
| title_short | Inter-ankle Systolic Blood Pressure Difference Is a Marker of Increased Fasting Blood-Glucose in Asian Pregnant Women |
| title_sort | inter ankle systolic blood pressure difference is a marker of increased fasting blood glucose in asian pregnant women |
| topic | ankle blood pressure doppler clinical blood pressure glucose metabolism OGTT (oral glucose tolerance test) pregnancy |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.842254/full |
| work_keys_str_mv | AT ruozhang interanklesystolicbloodpressuredifferenceisamarkerofincreasedfastingbloodglucoseinasianpregnantwomen AT hemaviswambharan interanklesystolicbloodpressuredifferenceisamarkerofincreasedfastingbloodglucoseinasianpregnantwomen AT chewwengcheng interanklesystolicbloodpressuredifferenceisamarkerofincreasedfastingbloodglucoseinasianpregnantwomen AT malgorzataannagarstka interanklesystolicbloodpressuredifferenceisamarkerofincreasedfastingbloodglucoseinasianpregnantwomen AT kirtikain interanklesystolicbloodpressuredifferenceisamarkerofincreasedfastingbloodglucoseinasianpregnantwomen |