Samotolisib Attenuates Acute Liver Injury Through Inhibiting Caspase-11-Mediated Pyroptosis Via Regulating E3 Ubiquitin Ligase Nedd4

Samotolisib Attenuates Acute Liver Injury Through Inhibiting Caspase-11-Mediated Pyroptosis Via Regulating E3 Ubiquitin Ligase Nedd4

Acute liver injury (ALI) is associated with poor survival in patients with sepsis. During sepsis, the liver is the main site of bacterial endotoxin-induced inflammation. Lipopolysaccharide (LPS) promotes caspase-4/5/11 activation, leading to pyroptosis, a major sepsis driver. This study aimed to ide...

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Bibliographic Details
Main Authors: Yang-Yang Zhao, Dong-Ming Wu, Miao He, Feng Zhang, Ting Zhang, Teng Liu, Jin Li, Li Li, Ying Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
samotolisib
acute liver injury
lipopolysaccharide
pyroptosis
caspase-11
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.726198/full

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