Induction of Localized Hyperthermia by Millisecond Laser Pulses in the Presence of Gold-Gold Sulphide Nanoparticles in a Phantom
Introduction Application of near-infrared absorbing nanostructures can induce hyperthermia, in addition to providing more efficient photothermal effects. Gold-gold sulfide (GGS) is considered as one of these nanostructures. This study was performed on a tissue-equivalent optical-thermal phantom to...
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Mashhad University of Medical Sciences
2015-05-01
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| Series: | Iranian Journal of Medical Physics |
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| Online Access: | http://ijmp.mums.ac.ir/pdf_4331_b3b834cdf3d31decf77d7fbcec0b789b.html |
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| author | Zahra Shahamat Mahin Shokouhi Ahmad- Reza Taheri Hossein Eshghi Neda Attaran- Kakhki Ameneh Sazgarnia |
| author_facet | Zahra Shahamat Mahin Shokouhi Ahmad- Reza Taheri Hossein Eshghi Neda Attaran- Kakhki Ameneh Sazgarnia |
| author_sort | Zahra Shahamat |
| collection | DOAJ |
| description | Introduction Application of near-infrared absorbing nanostructures can induce hyperthermia, in addition to providing more efficient photothermal effects. Gold-gold sulfide (GGS) is considered as one of these nanostructures. This study was performed on a tissue-equivalent optical-thermal phantom to determine the temperature profile in the presence and absence of GGS and millisecond pulses of a near-infrared laser. Moreover, the feasibility of hyperthermia induction was investigated in a simulated tumor. Materials and Methods A tumor with its surrounding tissues was simulated in a phantom made of Agarose and Intralipid. The tumor was irradiated by 30 laser pulses with durations of 30, 100, and 400 ms and fluences of 40 and 60 J/cm2. Temperature variations in the phantom with and without GGS were recorded, using fast-response sensors of a digital thermometer, placed at different distances from the central axis at three depths. The temperature rise was recorded by varying duration and fluence of the laser pulses. Results The rise in temperature was recorded by increasing laser fluence and number of pulses for three durations. The temperature profile was obtained at each depth. The presence of GGS resulted in a significant increase in temperature in all cases (P |
| first_indexed | 2024-12-22T06:06:43Z |
| format | Article |
| id | doaj.art-77358981b7f14121850984ad62a0c315 |
| institution | Directory Open Access Journal |
| issn | 2252-0309 2345-3672 |
| language | English |
| last_indexed | 2024-12-22T06:06:43Z |
| publishDate | 2015-05-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Medical Physics |
| spelling | doaj.art-77358981b7f14121850984ad62a0c3152022-12-21T18:36:24ZengMashhad University of Medical SciencesIranian Journal of Medical Physics2252-03092345-36722015-05-0112149614331Induction of Localized Hyperthermia by Millisecond Laser Pulses in the Presence of Gold-Gold Sulphide Nanoparticles in a PhantomZahra Shahamat0Mahin Shokouhi1Ahmad- Reza Taheri2Hossein Eshghi3Neda Attaran- Kakhki4Ameneh Sazgarnia5Medical physics Dept., Research Center of Medical Physics, Mashhad University of Medical Sciences, Mashhad, IranMedical physics Dept., Research Center of Medical Physics, Mashhad University of Medical Sciences, Mashhad, IranCutaneous Leishmaniasis Research Center, Department of Dermatology, Mashhad University of Medical Sciences, Mashhad, IranDepartment of chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, IranDepartment of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, IranMedical physics Dept., Research Center of Medical Physics, Mashhad University of Medical Sciences, Mashhad, IranIntroduction Application of near-infrared absorbing nanostructures can induce hyperthermia, in addition to providing more efficient photothermal effects. Gold-gold sulfide (GGS) is considered as one of these nanostructures. This study was performed on a tissue-equivalent optical-thermal phantom to determine the temperature profile in the presence and absence of GGS and millisecond pulses of a near-infrared laser. Moreover, the feasibility of hyperthermia induction was investigated in a simulated tumor. Materials and Methods A tumor with its surrounding tissues was simulated in a phantom made of Agarose and Intralipid. The tumor was irradiated by 30 laser pulses with durations of 30, 100, and 400 ms and fluences of 40 and 60 J/cm2. Temperature variations in the phantom with and without GGS were recorded, using fast-response sensors of a digital thermometer, placed at different distances from the central axis at three depths. The temperature rise was recorded by varying duration and fluence of the laser pulses. Results The rise in temperature was recorded by increasing laser fluence and number of pulses for three durations. The temperature profile was obtained at each depth. The presence of GGS resulted in a significant increase in temperature in all cases (Phttp://ijmp.mums.ac.ir/pdf_4331_b3b834cdf3d31decf77d7fbcec0b789b.htmlHyperthermiaPhotothermal TherapyPulse DurationGold-Gold SulfideNIR Laser |
| spellingShingle | Zahra Shahamat Mahin Shokouhi Ahmad- Reza Taheri Hossein Eshghi Neda Attaran- Kakhki Ameneh Sazgarnia Induction of Localized Hyperthermia by Millisecond Laser Pulses in the Presence of Gold-Gold Sulphide Nanoparticles in a Phantom Iranian Journal of Medical Physics Hyperthermia Photothermal Therapy Pulse Duration Gold-Gold Sulfide NIR Laser |
| title | Induction of Localized Hyperthermia by Millisecond Laser Pulses in the Presence of Gold-Gold Sulphide Nanoparticles in a Phantom |
| title_full | Induction of Localized Hyperthermia by Millisecond Laser Pulses in the Presence of Gold-Gold Sulphide Nanoparticles in a Phantom |
| title_fullStr | Induction of Localized Hyperthermia by Millisecond Laser Pulses in the Presence of Gold-Gold Sulphide Nanoparticles in a Phantom |
| title_full_unstemmed | Induction of Localized Hyperthermia by Millisecond Laser Pulses in the Presence of Gold-Gold Sulphide Nanoparticles in a Phantom |
| title_short | Induction of Localized Hyperthermia by Millisecond Laser Pulses in the Presence of Gold-Gold Sulphide Nanoparticles in a Phantom |
| title_sort | induction of localized hyperthermia by millisecond laser pulses in the presence of gold gold sulphide nanoparticles in a phantom |
| topic | Hyperthermia Photothermal Therapy Pulse Duration Gold-Gold Sulfide NIR Laser |
| url | http://ijmp.mums.ac.ir/pdf_4331_b3b834cdf3d31decf77d7fbcec0b789b.html |
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