Elevated NT-proBNP levels are associated with CTP ischemic volume and 90-day functional outcomes in acute ischemic stroke: a retrospective cohort study
Abstract Objective To investigate the impact of N-terminal pro-B-type natriuretic peptide (NT-proBNP) on CTP infarct core volume and poor 90-day functional outcomes in acute ischemic stroke (AIS). Methods A total of 403 hospitalized patients with AIS in the Stroke Center of the First Hospital Affili...
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-022-02861-w |
| _version_ | 1811253636246798336 |
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| author | Xiaozhu Shen Juan Liao Yi Jiang Yiwen Xu Mengqian Liu Xianxian Zhang Nan Dong Liqiang Yu Qingmei Chen Qi Fang |
| author_facet | Xiaozhu Shen Juan Liao Yi Jiang Yiwen Xu Mengqian Liu Xianxian Zhang Nan Dong Liqiang Yu Qingmei Chen Qi Fang |
| author_sort | Xiaozhu Shen |
| collection | DOAJ |
| description | Abstract Objective To investigate the impact of N-terminal pro-B-type natriuretic peptide (NT-proBNP) on CTP infarct core volume and poor 90-day functional outcomes in acute ischemic stroke (AIS). Methods A total of 403 hospitalized patients with AIS in the Stroke Center of the First Hospital Affiliated to Soochow University were enrolled from March 2018 to January 2021. The association between NT-proBNP and clinical outcomes in acute ischemic patients was assessed by logistic regression and adjusted for confounding factors. Also, subgroup analyses were conducted based on treatment decisions. Results NT-proBNP was positively correlated with CTP ischemic volume (p < 0.001), infarct core volume (p < 0.001), and ischemic penumbra volume (p < 0.001). Univariate analysis showed that the influence of NT-proBNP and functional outcomes were statistically significant in model 1 (p = 0.002). This phenomenon was persistent after adjusted for age, sex, and body mass index in model 2 (p = 0.011), adjusted for SBP, current smoking, family history of stroke, hypertension, and diabetes mellitus in model 3 (p < 0.001), and adjusted for TnI, D-dimer, PLT, Cr, TC, TG, HDL-C, treatment decisions, and NIHSS score in model 4 (p = 0.027). A high NT-proBNP was associated with a high 90-days mRS score among the total population, IV rt-PA, and standardized treatment groups, but not in IV rt-PA + EVT, EVT, and EVT/IV rt-PA + EVT groups. Conclusion Elevated NT-proBNP levels reveal large CTP infarct core volume and poor 90-day functional outcome in AIS. NT-pro BNP is an independent risk factor for functional outcomes. |
| first_indexed | 2024-04-12T16:53:56Z |
| format | Article |
| id | doaj.art-773636bc8c7347cd955e973618b17e3e |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-12T16:53:56Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-773636bc8c7347cd955e973618b17e3e2022-12-22T03:24:18ZengBMCBMC Cardiovascular Disorders1471-22612022-09-0122111010.1186/s12872-022-02861-wElevated NT-proBNP levels are associated with CTP ischemic volume and 90-day functional outcomes in acute ischemic stroke: a retrospective cohort studyXiaozhu Shen0Juan Liao1Yi Jiang2Yiwen Xu3Mengqian Liu4Xianxian Zhang5Nan Dong6Liqiang Yu7Qingmei Chen8Qi Fang9Department of Neurology, The First Affiliated Hospital of Soochow UniversityDepartment of Neurology, The First Affiliated Hospital of Soochow UniversityDepartment of Geriatrics, Lianyungang Second People’s HospitalDepartment of Geriatrics, Lianyungang Second People’s HospitalDepartment of Geriatrics, Lianyungang Second People’s HospitalDepartment of Neurology, The First Affiliated Hospital of Soochow UniversityDepartment of Neurology, The First Affiliated Hospital of Soochow UniversityDepartment of Neurology, The First Affiliated Hospital of Soochow UniversityDepartment of Neurology, The First Affiliated Hospital of Soochow UniversityDepartment of Neurology, The First Affiliated Hospital of Soochow UniversityAbstract Objective To investigate the impact of N-terminal pro-B-type natriuretic peptide (NT-proBNP) on CTP infarct core volume and poor 90-day functional outcomes in acute ischemic stroke (AIS). Methods A total of 403 hospitalized patients with AIS in the Stroke Center of the First Hospital Affiliated to Soochow University were enrolled from March 2018 to January 2021. The association between NT-proBNP and clinical outcomes in acute ischemic patients was assessed by logistic regression and adjusted for confounding factors. Also, subgroup analyses were conducted based on treatment decisions. Results NT-proBNP was positively correlated with CTP ischemic volume (p < 0.001), infarct core volume (p < 0.001), and ischemic penumbra volume (p < 0.001). Univariate analysis showed that the influence of NT-proBNP and functional outcomes were statistically significant in model 1 (p = 0.002). This phenomenon was persistent after adjusted for age, sex, and body mass index in model 2 (p = 0.011), adjusted for SBP, current smoking, family history of stroke, hypertension, and diabetes mellitus in model 3 (p < 0.001), and adjusted for TnI, D-dimer, PLT, Cr, TC, TG, HDL-C, treatment decisions, and NIHSS score in model 4 (p = 0.027). A high NT-proBNP was associated with a high 90-days mRS score among the total population, IV rt-PA, and standardized treatment groups, but not in IV rt-PA + EVT, EVT, and EVT/IV rt-PA + EVT groups. Conclusion Elevated NT-proBNP levels reveal large CTP infarct core volume and poor 90-day functional outcome in AIS. NT-pro BNP is an independent risk factor for functional outcomes.https://doi.org/10.1186/s12872-022-02861-wAcute ischemic strokeN-terminal pro-B-type natriureticOutcomesCTP perfusionTreatment decisions |
| spellingShingle | Xiaozhu Shen Juan Liao Yi Jiang Yiwen Xu Mengqian Liu Xianxian Zhang Nan Dong Liqiang Yu Qingmei Chen Qi Fang Elevated NT-proBNP levels are associated with CTP ischemic volume and 90-day functional outcomes in acute ischemic stroke: a retrospective cohort study BMC Cardiovascular Disorders Acute ischemic stroke N-terminal pro-B-type natriuretic Outcomes CTP perfusion Treatment decisions |
| title | Elevated NT-proBNP levels are associated with CTP ischemic volume and 90-day functional outcomes in acute ischemic stroke: a retrospective cohort study |
| title_full | Elevated NT-proBNP levels are associated with CTP ischemic volume and 90-day functional outcomes in acute ischemic stroke: a retrospective cohort study |
| title_fullStr | Elevated NT-proBNP levels are associated with CTP ischemic volume and 90-day functional outcomes in acute ischemic stroke: a retrospective cohort study |
| title_full_unstemmed | Elevated NT-proBNP levels are associated with CTP ischemic volume and 90-day functional outcomes in acute ischemic stroke: a retrospective cohort study |
| title_short | Elevated NT-proBNP levels are associated with CTP ischemic volume and 90-day functional outcomes in acute ischemic stroke: a retrospective cohort study |
| title_sort | elevated nt probnp levels are associated with ctp ischemic volume and 90 day functional outcomes in acute ischemic stroke a retrospective cohort study |
| topic | Acute ischemic stroke N-terminal pro-B-type natriuretic Outcomes CTP perfusion Treatment decisions |
| url | https://doi.org/10.1186/s12872-022-02861-w |
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