Brain health registry GenePool study: A novel approach to online genetics research
Abstract Introduction Remote data collection, including the establishment of online registries, is a novel approach to efficiently identify risk for cognitive decline and Alzheimer's disease (AD) in older adults, with growing evidence for feasibility and validity. Addition of genetic data to on...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/trc2.12118 |
| _version_ | 1817975373534593024 |
|---|---|
| author | Juliet Fockler Winnie Kwang Miriam T. Ashford Derek Flenniken Joshua Hwang Diana Truran R. Scott Mackin Chengshi Jin Ruth O'Hara Joachim F. Hallmayer Jerome A. Yesavage Michael W. Weiner Rachel L. Nosheny |
| author_facet | Juliet Fockler Winnie Kwang Miriam T. Ashford Derek Flenniken Joshua Hwang Diana Truran R. Scott Mackin Chengshi Jin Ruth O'Hara Joachim F. Hallmayer Jerome A. Yesavage Michael W. Weiner Rachel L. Nosheny |
| author_sort | Juliet Fockler |
| collection | DOAJ |
| description | Abstract Introduction Remote data collection, including the establishment of online registries, is a novel approach to efficiently identify risk for cognitive decline and Alzheimer's disease (AD) in older adults, with growing evidence for feasibility and validity. Addition of genetic data to online registries has the potential to facilitate identification of older adults at risk and to advance the understanding of genetic contributions to AD. Methods 573 older adult participants with longitudinal online Brain Health Registry (BHR) data underwent apolipoprotein E (APOE) genotyping using remotely collected saliva samples and a novel, automated Biofluid Collection Management Portal. We evaluated acceptability of genetic sample collection and estimated associations between (1) sociodemographic variables and willingness to participate in genetics research and (2) APOE results and online cognitive and functional assessments. We also assessed acceptance of hypothetical genetics research participation by surveying a larger sample of 25,888 BHR participants. Results 51% of invited participants enrolled in the BHR genetics study, BHR‐GenePool Study (BHR‐GPS); 27% of participants had at least one APOE ε4 allele. Older participants and those with higher educational attainment were more likely to participate. In the remotely administered Cogstate Brief Battery, APOE ε4/ε4 homozygotes (HM) had worse online learning scores, and greater decline in processing speed and attention, compared to ε3/ε4 heterozygotes (HT) and ε4 non‐carriers (NC). Discussion APOE genotyping of more than 500 older adults enrolled in BHR supports the feasibility and validity of a novel, remote biofluids collection approach from a large cohort of older adults, with data linkage to longitudinal online cognitive data. This approach can be expanded for efficient collection of genetic data and other information from biofluids in the future. |
| first_indexed | 2024-04-13T21:48:03Z |
| format | Article |
| id | doaj.art-77365c05c256414eba0558b0c2eb910b |
| institution | Directory Open Access Journal |
| issn | 2352-8737 |
| language | English |
| last_indexed | 2024-04-13T21:48:03Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj.art-77365c05c256414eba0558b0c2eb910b2022-12-22T02:28:29ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372021-01-0171n/an/a10.1002/trc2.12118Brain health registry GenePool study: A novel approach to online genetics researchJuliet Fockler0Winnie Kwang1Miriam T. Ashford2Derek Flenniken3Joshua Hwang4Diana Truran5R. Scott Mackin6Chengshi Jin7Ruth O'Hara8Joachim F. Hallmayer9Jerome A. Yesavage10Michael W. Weiner11Rachel L. Nosheny12VA Advanced Imaging Research Center San Francisco Veteran's Administration Medical Center San Francisco California USAVA Advanced Imaging Research Center San Francisco Veteran's Administration Medical Center San Francisco California USAVA Advanced Imaging Research Center San Francisco Veteran's Administration Medical Center San Francisco California USAVA Advanced Imaging Research Center San Francisco Veteran's Administration Medical Center San Francisco California USAVA Advanced Imaging Research Center San Francisco Veteran's Administration Medical Center San Francisco California USAVA Advanced Imaging Research Center San Francisco Veteran's Administration Medical Center San Francisco California USAVA Advanced Imaging Research Center San Francisco Veteran's Administration Medical Center San Francisco California USASan Francisco Department of Biostatistics and Epidemiology University of California, San Francisco San Francisco California USADepartment of Psychiatry and Behavioral Sciences Stanford University Stanford California USADepartment of Psychiatry and Behavioral Sciences Stanford University Stanford California USADepartment of Psychiatry and Behavioral Sciences Stanford University Stanford California USAVA Advanced Imaging Research Center San Francisco Veteran's Administration Medical Center San Francisco California USAVA Advanced Imaging Research Center San Francisco Veteran's Administration Medical Center San Francisco California USAAbstract Introduction Remote data collection, including the establishment of online registries, is a novel approach to efficiently identify risk for cognitive decline and Alzheimer's disease (AD) in older adults, with growing evidence for feasibility and validity. Addition of genetic data to online registries has the potential to facilitate identification of older adults at risk and to advance the understanding of genetic contributions to AD. Methods 573 older adult participants with longitudinal online Brain Health Registry (BHR) data underwent apolipoprotein E (APOE) genotyping using remotely collected saliva samples and a novel, automated Biofluid Collection Management Portal. We evaluated acceptability of genetic sample collection and estimated associations between (1) sociodemographic variables and willingness to participate in genetics research and (2) APOE results and online cognitive and functional assessments. We also assessed acceptance of hypothetical genetics research participation by surveying a larger sample of 25,888 BHR participants. Results 51% of invited participants enrolled in the BHR genetics study, BHR‐GenePool Study (BHR‐GPS); 27% of participants had at least one APOE ε4 allele. Older participants and those with higher educational attainment were more likely to participate. In the remotely administered Cogstate Brief Battery, APOE ε4/ε4 homozygotes (HM) had worse online learning scores, and greater decline in processing speed and attention, compared to ε3/ε4 heterozygotes (HT) and ε4 non‐carriers (NC). Discussion APOE genotyping of more than 500 older adults enrolled in BHR supports the feasibility and validity of a novel, remote biofluids collection approach from a large cohort of older adults, with data linkage to longitudinal online cognitive data. This approach can be expanded for efficient collection of genetic data and other information from biofluids in the future.https://doi.org/10.1002/trc2.12118aging researchAlzheimer's diseaseapolipoprotein EBrain Health Registrygeneticsinternet |
| spellingShingle | Juliet Fockler Winnie Kwang Miriam T. Ashford Derek Flenniken Joshua Hwang Diana Truran R. Scott Mackin Chengshi Jin Ruth O'Hara Joachim F. Hallmayer Jerome A. Yesavage Michael W. Weiner Rachel L. Nosheny Brain health registry GenePool study: A novel approach to online genetics research Alzheimer’s & Dementia: Translational Research & Clinical Interventions aging research Alzheimer's disease apolipoprotein E Brain Health Registry genetics internet |
| title | Brain health registry GenePool study: A novel approach to online genetics research |
| title_full | Brain health registry GenePool study: A novel approach to online genetics research |
| title_fullStr | Brain health registry GenePool study: A novel approach to online genetics research |
| title_full_unstemmed | Brain health registry GenePool study: A novel approach to online genetics research |
| title_short | Brain health registry GenePool study: A novel approach to online genetics research |
| title_sort | brain health registry genepool study a novel approach to online genetics research |
| topic | aging research Alzheimer's disease apolipoprotein E Brain Health Registry genetics internet |
| url | https://doi.org/10.1002/trc2.12118 |
| work_keys_str_mv | AT julietfockler brainhealthregistrygenepoolstudyanovelapproachtoonlinegeneticsresearch AT winniekwang brainhealthregistrygenepoolstudyanovelapproachtoonlinegeneticsresearch AT miriamtashford brainhealthregistrygenepoolstudyanovelapproachtoonlinegeneticsresearch AT derekflenniken brainhealthregistrygenepoolstudyanovelapproachtoonlinegeneticsresearch AT joshuahwang brainhealthregistrygenepoolstudyanovelapproachtoonlinegeneticsresearch AT dianatruran brainhealthregistrygenepoolstudyanovelapproachtoonlinegeneticsresearch AT rscottmackin brainhealthregistrygenepoolstudyanovelapproachtoonlinegeneticsresearch AT chengshijin brainhealthregistrygenepoolstudyanovelapproachtoonlinegeneticsresearch AT ruthohara brainhealthregistrygenepoolstudyanovelapproachtoonlinegeneticsresearch AT joachimfhallmayer brainhealthregistrygenepoolstudyanovelapproachtoonlinegeneticsresearch AT jeromeayesavage brainhealthregistrygenepoolstudyanovelapproachtoonlinegeneticsresearch AT michaelwweiner brainhealthregistrygenepoolstudyanovelapproachtoonlinegeneticsresearch AT rachellnosheny brainhealthregistrygenepoolstudyanovelapproachtoonlinegeneticsresearch |