The Multi-Faceted Role of Autophagy During Animal Virus Infection
Autophagy is a process of degradation to maintain cellular homeostatic by lysosomes, which ensures cellular survival under various stress conditions, including nutrient deficiency, hypoxia, high temperature, and pathogenic infection. Xenophagy, a form of selective autophagy, serves as a defense mech...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.858953/full |
| _version_ | 1811332202418405376 |
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| author | Hui Jiang Xianjin Kan Chan Ding Chan Ding Yingjie Sun |
| author_facet | Hui Jiang Xianjin Kan Chan Ding Chan Ding Yingjie Sun |
| author_sort | Hui Jiang |
| collection | DOAJ |
| description | Autophagy is a process of degradation to maintain cellular homeostatic by lysosomes, which ensures cellular survival under various stress conditions, including nutrient deficiency, hypoxia, high temperature, and pathogenic infection. Xenophagy, a form of selective autophagy, serves as a defense mechanism against multiple intracellular pathogen types, such as viruses, bacteria, and parasites. Recent years have seen a growing list of animal viruses with autophagy machinery. Although the relationship between autophagy and human viruses has been widely summarized, little attention has been paid to the role of this cellular function in the veterinary field, especially today, with the growth of serious zoonotic diseases. The mechanisms of the same virus inducing autophagy in different species, or different viruses inducing autophagy in the same species have not been clarified. In this review, we examine the role of autophagy in important animal viral infectious diseases and discuss the regulation mechanisms of different animal viruses to provide a potential theoretical basis for therapeutic strategies, such as targets of new vaccine development or drugs, to improve industrial production in farming. |
| first_indexed | 2024-04-13T16:32:28Z |
| format | Article |
| id | doaj.art-773774c0225145bba63c6b07dfc4b7d6 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-13T16:32:28Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-773774c0225145bba63c6b07dfc4b7d62022-12-22T02:39:31ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-03-011210.3389/fcimb.2022.858953858953The Multi-Faceted Role of Autophagy During Animal Virus InfectionHui Jiang0Xianjin Kan1Chan Ding2Chan Ding3Yingjie Sun4Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute. Chinese Academy of Agricultural Science, Shanghai, ChinaDepartment of Avian Infectious Diseases, Shanghai Veterinary Research Institute. Chinese Academy of Agricultural Science, Shanghai, ChinaDepartment of Avian Infectious Diseases, Shanghai Veterinary Research Institute. Chinese Academy of Agricultural Science, Shanghai, ChinaJiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou University, Yangzhou, ChinaDepartment of Avian Infectious Diseases, Shanghai Veterinary Research Institute. Chinese Academy of Agricultural Science, Shanghai, ChinaAutophagy is a process of degradation to maintain cellular homeostatic by lysosomes, which ensures cellular survival under various stress conditions, including nutrient deficiency, hypoxia, high temperature, and pathogenic infection. Xenophagy, a form of selective autophagy, serves as a defense mechanism against multiple intracellular pathogen types, such as viruses, bacteria, and parasites. Recent years have seen a growing list of animal viruses with autophagy machinery. Although the relationship between autophagy and human viruses has been widely summarized, little attention has been paid to the role of this cellular function in the veterinary field, especially today, with the growth of serious zoonotic diseases. The mechanisms of the same virus inducing autophagy in different species, or different viruses inducing autophagy in the same species have not been clarified. In this review, we examine the role of autophagy in important animal viral infectious diseases and discuss the regulation mechanisms of different animal viruses to provide a potential theoretical basis for therapeutic strategies, such as targets of new vaccine development or drugs, to improve industrial production in farming.https://www.frontiersin.org/articles/10.3389/fcimb.2022.858953/fullautophagyanimal viruszoonotic diseasesporcineavian |
| spellingShingle | Hui Jiang Xianjin Kan Chan Ding Chan Ding Yingjie Sun The Multi-Faceted Role of Autophagy During Animal Virus Infection Frontiers in Cellular and Infection Microbiology autophagy animal virus zoonotic diseases porcine avian |
| title | The Multi-Faceted Role of Autophagy During Animal Virus Infection |
| title_full | The Multi-Faceted Role of Autophagy During Animal Virus Infection |
| title_fullStr | The Multi-Faceted Role of Autophagy During Animal Virus Infection |
| title_full_unstemmed | The Multi-Faceted Role of Autophagy During Animal Virus Infection |
| title_short | The Multi-Faceted Role of Autophagy During Animal Virus Infection |
| title_sort | multi faceted role of autophagy during animal virus infection |
| topic | autophagy animal virus zoonotic diseases porcine avian |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.858953/full |
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