Similar Skin Barrier Function in Persons with Type 1 Diabetes Compared with Healthy Controls
Contact dermatitis because of use of diabetes devices is frequent in individuals with type 1 diabetes (TD1), especially in the pediatric age group, but the putative role of a constitutional impaired skin barrier in persons with TD1 is unclear. This study examined the skin barrier function by the mea...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
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| Series: | JID Innovations |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266702672300022X |
| _version_ | 1797774487820697600 |
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| author | Anna Korsgaard Berg Annemarie Cecilie Grauslund Kirsten Nørgaard Steffen Ullitz Thorsen Claus Zachariae Anne-Sofie Halling Ivone Jakasa Sanja Kezic Jannet Svensson Jacob P. Thyssen |
| author_facet | Anna Korsgaard Berg Annemarie Cecilie Grauslund Kirsten Nørgaard Steffen Ullitz Thorsen Claus Zachariae Anne-Sofie Halling Ivone Jakasa Sanja Kezic Jannet Svensson Jacob P. Thyssen |
| author_sort | Anna Korsgaard Berg |
| collection | DOAJ |
| description | Contact dermatitis because of use of diabetes devices is frequent in individuals with type 1 diabetes (TD1), especially in the pediatric age group, but the putative role of a constitutional impaired skin barrier in persons with TD1 is unclear. This study examined the skin barrier function by the measurement of natural moisturizing factor and free cytokines collected through skin tape strips, as well as biophysical markers and the skin microbiome, in persons with TD1 than to age- and sex-matched healthy controls. All measurements were done in nonlesional skin. We found that the skin barrier function was similar in children and adolescents with TD1 than to controls but found that the beta-diversity of skin microbiome at the buttock differed between the two groups. We conclude that individuals with TD1 have normal skin barrier function, and that the increased occurrence of contact dermatitis following pump and sensor use is explained by exogenous factors. |
| first_indexed | 2024-03-12T22:21:50Z |
| format | Article |
| id | doaj.art-77393100a3d54b9791d5e86835c457e6 |
| institution | Directory Open Access Journal |
| issn | 2667-0267 |
| language | English |
| last_indexed | 2024-03-12T22:21:50Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JID Innovations |
| spelling | doaj.art-77393100a3d54b9791d5e86835c457e62023-07-23T04:56:23ZengElsevierJID Innovations2667-02672023-07-0134100200Similar Skin Barrier Function in Persons with Type 1 Diabetes Compared with Healthy ControlsAnna Korsgaard Berg0Annemarie Cecilie Grauslund1Kirsten Nørgaard2Steffen Ullitz Thorsen3Claus Zachariae4Anne-Sofie Halling5Ivone Jakasa6Sanja Kezic7Jannet Svensson8Jacob P. Thyssen9Department of Pediatrics, Herlev and Gentofte Hospital, Herlev, Denmark; Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark; Correspondence: Anna Korsgaard Berg, Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark, Borgmester Ib Juuls Vej 83, 2730 Herlev, DenmarkDepartment of Pediatrics, Herlev and Gentofte Hospital, Herlev, DenmarkCopenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, DenmarkDepartment of Pediatrics, Herlev and Gentofte Hospital, Herlev, Denmark; Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, DenmarkDepartment of Dermatology and Allergy, Herlev and Gentofte Hospital, Gentofte, DenmarkDepartment of Dermatology and Venerology, Bispebjerg Hospital, DenmarkLaboratory for Analytical Chemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, CroatiaDepartment of Occupational and Public Health, Amsterdam UMC, The NetherlandsDepartment of Pediatrics, Herlev and Gentofte Hospital, Herlev, Denmark; Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, DenmarkDepartment of Dermatology and Venerology, Bispebjerg Hospital, DenmarkContact dermatitis because of use of diabetes devices is frequent in individuals with type 1 diabetes (TD1), especially in the pediatric age group, but the putative role of a constitutional impaired skin barrier in persons with TD1 is unclear. This study examined the skin barrier function by the measurement of natural moisturizing factor and free cytokines collected through skin tape strips, as well as biophysical markers and the skin microbiome, in persons with TD1 than to age- and sex-matched healthy controls. All measurements were done in nonlesional skin. We found that the skin barrier function was similar in children and adolescents with TD1 than to controls but found that the beta-diversity of skin microbiome at the buttock differed between the two groups. We conclude that individuals with TD1 have normal skin barrier function, and that the increased occurrence of contact dermatitis following pump and sensor use is explained by exogenous factors.http://www.sciencedirect.com/science/article/pii/S266702672300022X |
| spellingShingle | Anna Korsgaard Berg Annemarie Cecilie Grauslund Kirsten Nørgaard Steffen Ullitz Thorsen Claus Zachariae Anne-Sofie Halling Ivone Jakasa Sanja Kezic Jannet Svensson Jacob P. Thyssen Similar Skin Barrier Function in Persons with Type 1 Diabetes Compared with Healthy Controls JID Innovations |
| title | Similar Skin Barrier Function in Persons with Type 1 Diabetes Compared with Healthy Controls |
| title_full | Similar Skin Barrier Function in Persons with Type 1 Diabetes Compared with Healthy Controls |
| title_fullStr | Similar Skin Barrier Function in Persons with Type 1 Diabetes Compared with Healthy Controls |
| title_full_unstemmed | Similar Skin Barrier Function in Persons with Type 1 Diabetes Compared with Healthy Controls |
| title_short | Similar Skin Barrier Function in Persons with Type 1 Diabetes Compared with Healthy Controls |
| title_sort | similar skin barrier function in persons with type 1 diabetes compared with healthy controls |
| url | http://www.sciencedirect.com/science/article/pii/S266702672300022X |
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