Lateralized brain activities in subcortical vascular mild cognitive impairment with differential Chinese medicine patterns: A resting-state functional magnetic resonance imaging study
BackgroundSubcortical vascular mild cognitive impairment (svMCI) is one of the most treatable cognitive impairments, but could be hampered by the high clinical heterogeneities. Further classification by Chinese Medicine (CM) patterns has been proved to stratify its clinical heterogeneities. It remai...
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.943929/full |
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| author | Jianjun Wang Jianjun Wang Jianjun Wang Fanxin Kong Fanxin Kong Haotao Zheng Haotao Zheng Dongbin Cai Dongbin Cai Lijin Liu Lijin Liu Jie Lian Jie Lian Hanqing Lyu Hanqing Lyu Songjun Lin Songjun Lin Jianxiang Chen Jianxiang Chen Xiude Qin Xiude Qin |
| author_facet | Jianjun Wang Jianjun Wang Jianjun Wang Fanxin Kong Fanxin Kong Haotao Zheng Haotao Zheng Dongbin Cai Dongbin Cai Lijin Liu Lijin Liu Jie Lian Jie Lian Hanqing Lyu Hanqing Lyu Songjun Lin Songjun Lin Jianxiang Chen Jianxiang Chen Xiude Qin Xiude Qin |
| author_sort | Jianjun Wang |
| collection | DOAJ |
| description | BackgroundSubcortical vascular mild cognitive impairment (svMCI) is one of the most treatable cognitive impairments, but could be hampered by the high clinical heterogeneities. Further classification by Chinese Medicine (CM) patterns has been proved to stratify its clinical heterogeneities. It remains largely unknown of the spontaneous brain activities regarding deficiency patterns (DPs) and excess patterns (EPs) of svMCI patients based on fMRI data.ObjectiveWe aim to provide neuroimaging evidence of altered resting-state brain activities associated with DPs and EPs in svMCI patients.MethodsThirty-seven svMCI patients (PAs) and 23 healthy controls (CNs) were consecutively enrolled. All patients were categorized into either the EP group (n = 16) and the DP group (n = 21) based on a quantitative CM scale. The fractional amplitude of low-frequency fluctuation (fALFF) value was used to make comparisons between different subgroups.ResultsThe DP group showed significant differences of fALFF values in the right middle frontal gyrus and the right cerebellum, while the EP group showed significant differences in the left orbitofrontal gyrus and the left cerebellum, when compared with the CN group. When compared with the EP group, the DP group had markedly increased fALFF values in the left superior temporal gyrus, right middle temporal gyrus and brainstem. The decreased fALFF values was shown in the right anterior cingulate and paracingulate gyri. Among the extensive areas of frontotemporal lobe, the Montreal Cognitive Assessment (MoCA) scores were significantly correlated with the reduced fALFF value of the right middle frontal gyrus and the left orbitofrontal gyrus.ConclusionOur results indicated that the DPs and EPs presented the lateralization pattern in the bilateral frontal gyrus, which will probably benefit the future investigation of the pathogenesis of svMCI patients. |
| first_indexed | 2024-04-14T03:02:45Z |
| format | Article |
| id | doaj.art-773a27c71a2f428d934d62e9124abd37 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-14T03:02:45Z |
| publishDate | 2022-08-01 |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-773a27c71a2f428d934d62e9124abd372022-12-22T02:15:52ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-08-011610.3389/fnins.2022.943929943929Lateralized brain activities in subcortical vascular mild cognitive impairment with differential Chinese medicine patterns: A resting-state functional magnetic resonance imaging studyJianjun Wang0Jianjun Wang1Jianjun Wang2Fanxin Kong3Fanxin Kong4Haotao Zheng5Haotao Zheng6Dongbin Cai7Dongbin Cai8Lijin Liu9Lijin Liu10Jie Lian11Jie Lian12Hanqing Lyu13Hanqing Lyu14Songjun Lin15Songjun Lin16Jianxiang Chen17Jianxiang Chen18Xiude Qin19Xiude Qin20Department of Neurology and Psychology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaThe Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, ChinaHarvard Medical School, Global Clinical Scholars Research Training (GCSRT), Boston, MA, United StatesDepartment of Neurology and Psychology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaThe Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, ChinaDepartment of Neurology and Psychology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaThe Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, ChinaDepartment of Neurology and Psychology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaThe Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, ChinaDepartment of Neurology and Psychology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaThe Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, ChinaDepartment of Neurology and Psychology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaThe Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, ChinaThe Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, ChinaDepartment of Radiology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaDepartment of Neurology and Psychology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaThe Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, ChinaThe Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, ChinaDepartment of Radiology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaDepartment of Neurology and Psychology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaThe Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, ChinaBackgroundSubcortical vascular mild cognitive impairment (svMCI) is one of the most treatable cognitive impairments, but could be hampered by the high clinical heterogeneities. Further classification by Chinese Medicine (CM) patterns has been proved to stratify its clinical heterogeneities. It remains largely unknown of the spontaneous brain activities regarding deficiency patterns (DPs) and excess patterns (EPs) of svMCI patients based on fMRI data.ObjectiveWe aim to provide neuroimaging evidence of altered resting-state brain activities associated with DPs and EPs in svMCI patients.MethodsThirty-seven svMCI patients (PAs) and 23 healthy controls (CNs) were consecutively enrolled. All patients were categorized into either the EP group (n = 16) and the DP group (n = 21) based on a quantitative CM scale. The fractional amplitude of low-frequency fluctuation (fALFF) value was used to make comparisons between different subgroups.ResultsThe DP group showed significant differences of fALFF values in the right middle frontal gyrus and the right cerebellum, while the EP group showed significant differences in the left orbitofrontal gyrus and the left cerebellum, when compared with the CN group. When compared with the EP group, the DP group had markedly increased fALFF values in the left superior temporal gyrus, right middle temporal gyrus and brainstem. The decreased fALFF values was shown in the right anterior cingulate and paracingulate gyri. Among the extensive areas of frontotemporal lobe, the Montreal Cognitive Assessment (MoCA) scores were significantly correlated with the reduced fALFF value of the right middle frontal gyrus and the left orbitofrontal gyrus.ConclusionOur results indicated that the DPs and EPs presented the lateralization pattern in the bilateral frontal gyrus, which will probably benefit the future investigation of the pathogenesis of svMCI patients.https://www.frontiersin.org/articles/10.3389/fnins.2022.943929/fullsubcortical vascular mild cognitive impairmentfALFFfMRIChinese medicinesyndrome differentiationdeficiency pattern |
| spellingShingle | Jianjun Wang Jianjun Wang Jianjun Wang Fanxin Kong Fanxin Kong Haotao Zheng Haotao Zheng Dongbin Cai Dongbin Cai Lijin Liu Lijin Liu Jie Lian Jie Lian Hanqing Lyu Hanqing Lyu Songjun Lin Songjun Lin Jianxiang Chen Jianxiang Chen Xiude Qin Xiude Qin Lateralized brain activities in subcortical vascular mild cognitive impairment with differential Chinese medicine patterns: A resting-state functional magnetic resonance imaging study Frontiers in Neuroscience subcortical vascular mild cognitive impairment fALFF fMRI Chinese medicine syndrome differentiation deficiency pattern |
| title | Lateralized brain activities in subcortical vascular mild cognitive impairment with differential Chinese medicine patterns: A resting-state functional magnetic resonance imaging study |
| title_full | Lateralized brain activities in subcortical vascular mild cognitive impairment with differential Chinese medicine patterns: A resting-state functional magnetic resonance imaging study |
| title_fullStr | Lateralized brain activities in subcortical vascular mild cognitive impairment with differential Chinese medicine patterns: A resting-state functional magnetic resonance imaging study |
| title_full_unstemmed | Lateralized brain activities in subcortical vascular mild cognitive impairment with differential Chinese medicine patterns: A resting-state functional magnetic resonance imaging study |
| title_short | Lateralized brain activities in subcortical vascular mild cognitive impairment with differential Chinese medicine patterns: A resting-state functional magnetic resonance imaging study |
| title_sort | lateralized brain activities in subcortical vascular mild cognitive impairment with differential chinese medicine patterns a resting state functional magnetic resonance imaging study |
| topic | subcortical vascular mild cognitive impairment fALFF fMRI Chinese medicine syndrome differentiation deficiency pattern |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.943929/full |
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