Role of Mitochondria-Cytoskeleton Interactions in the Regulation of Mitochondrial Structure and Function in Cancer Stem Cells
Despite the promise of cancer medicine, major challenges currently confronting the treatment of cancer patients include chemoresistance and recurrence. The existence of subpopulations of cancer cells, known as cancer stem cells (CSCs), contributes to the failure of cancer therapies and is associated...
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| Format: | Article |
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MDPI AG
2020-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/7/1691 |
| _version_ | 1797562473672343552 |
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| author | Jungmin Kim Jae-Ho Cheong |
| author_facet | Jungmin Kim Jae-Ho Cheong |
| author_sort | Jungmin Kim |
| collection | DOAJ |
| description | Despite the promise of cancer medicine, major challenges currently confronting the treatment of cancer patients include chemoresistance and recurrence. The existence of subpopulations of cancer cells, known as cancer stem cells (CSCs), contributes to the failure of cancer therapies and is associated with poor clinical outcomes. Of note, one of the recently characterized features of CSCs is augmented mitochondrial function. The cytoskeleton network is essential in regulating mitochondrial morphology and rearrangement, which are inextricably linked to its functions, such as oxidative phosphorylation (OXPHOS). The interaction between the cytoskeleton and mitochondria can enable CSCs to adapt to challenging conditions, such as a lack of energy sources, and to maintain their stemness. Cytoskeleton-mediated mitochondrial trafficking and relocating to the high energy requirement region are crucial steps in epithelial-to-mesenchymal transition (EMT). In addition, the cytoskeleton itself interplays with and blocks the voltage-dependent anion channel (VDAC) to directly regulate bioenergetics. In this review, we describe the regulation of cellular bioenergetics in CSCs, focusing on the cytoskeleton-mediated dynamic control of mitochondrial structure and function. |
| first_indexed | 2024-03-10T18:29:42Z |
| format | Article |
| id | doaj.art-773b8598da6c423099a0e139ee9eab03 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T18:29:42Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-773b8598da6c423099a0e139ee9eab032023-11-20T06:45:20ZengMDPI AGCells2073-44092020-07-0197169110.3390/cells9071691Role of Mitochondria-Cytoskeleton Interactions in the Regulation of Mitochondrial Structure and Function in Cancer Stem CellsJungmin Kim0Jae-Ho Cheong1Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, KoreaBrain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, KoreaDespite the promise of cancer medicine, major challenges currently confronting the treatment of cancer patients include chemoresistance and recurrence. The existence of subpopulations of cancer cells, known as cancer stem cells (CSCs), contributes to the failure of cancer therapies and is associated with poor clinical outcomes. Of note, one of the recently characterized features of CSCs is augmented mitochondrial function. The cytoskeleton network is essential in regulating mitochondrial morphology and rearrangement, which are inextricably linked to its functions, such as oxidative phosphorylation (OXPHOS). The interaction between the cytoskeleton and mitochondria can enable CSCs to adapt to challenging conditions, such as a lack of energy sources, and to maintain their stemness. Cytoskeleton-mediated mitochondrial trafficking and relocating to the high energy requirement region are crucial steps in epithelial-to-mesenchymal transition (EMT). In addition, the cytoskeleton itself interplays with and blocks the voltage-dependent anion channel (VDAC) to directly regulate bioenergetics. In this review, we describe the regulation of cellular bioenergetics in CSCs, focusing on the cytoskeleton-mediated dynamic control of mitochondrial structure and function.https://www.mdpi.com/2073-4409/9/7/1691cytoskeletontubulincytoskeleton-mitochondriacancer stem cellcancer mitochondriacancer metabolism |
| spellingShingle | Jungmin Kim Jae-Ho Cheong Role of Mitochondria-Cytoskeleton Interactions in the Regulation of Mitochondrial Structure and Function in Cancer Stem Cells Cells cytoskeleton tubulin cytoskeleton-mitochondria cancer stem cell cancer mitochondria cancer metabolism |
| title | Role of Mitochondria-Cytoskeleton Interactions in the Regulation of Mitochondrial Structure and Function in Cancer Stem Cells |
| title_full | Role of Mitochondria-Cytoskeleton Interactions in the Regulation of Mitochondrial Structure and Function in Cancer Stem Cells |
| title_fullStr | Role of Mitochondria-Cytoskeleton Interactions in the Regulation of Mitochondrial Structure and Function in Cancer Stem Cells |
| title_full_unstemmed | Role of Mitochondria-Cytoskeleton Interactions in the Regulation of Mitochondrial Structure and Function in Cancer Stem Cells |
| title_short | Role of Mitochondria-Cytoskeleton Interactions in the Regulation of Mitochondrial Structure and Function in Cancer Stem Cells |
| title_sort | role of mitochondria cytoskeleton interactions in the regulation of mitochondrial structure and function in cancer stem cells |
| topic | cytoskeleton tubulin cytoskeleton-mitochondria cancer stem cell cancer mitochondria cancer metabolism |
| url | https://www.mdpi.com/2073-4409/9/7/1691 |
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