lncRNA-disease association prediction based on latent factor model and projection
Abstract Computer aided research of lncRNA-disease association is an important way to study the development of lncRNA-disease. The correlation analysis of existing data, the establishment of prediction model, prediction of unknown lncRNA-disease association, can make the biological experiment target...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-99493-5 |
| _version_ | 1818691963726069760 |
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| author | Bo Wang Chao Zhang Xiao-xin Du Jian-fei Zhang |
| author_facet | Bo Wang Chao Zhang Xiao-xin Du Jian-fei Zhang |
| author_sort | Bo Wang |
| collection | DOAJ |
| description | Abstract Computer aided research of lncRNA-disease association is an important way to study the development of lncRNA-disease. The correlation analysis of existing data, the establishment of prediction model, prediction of unknown lncRNA-disease association, can make the biological experiment targeted, improve the accuracy of biological experiment. In this paper, a lncRNA-disease association prediction model based on latent factor model and projection is proposed (LFMP). This method uses lncRNA-miRNA association data and miRNA-disease association data to predict the unknown lncRNA-disease association, so this method does not need lncRNA-disease association data. The simulation results show that under the LOOCV framework, the AUC of LFMP can reach 0.8964. Better than the latest results. Through the case study of lung and colorectal tumors, LFMP can effectively infer the undetected lncRNA-disease association. |
| first_indexed | 2024-12-17T12:50:15Z |
| format | Article |
| id | doaj.art-773e8f73e6c04adfb6520c47f3037361 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T12:50:15Z |
| publishDate | 2021-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-773e8f73e6c04adfb6520c47f30373612022-12-21T21:47:38ZengNature PortfolioScientific Reports2045-23222021-10-0111111010.1038/s41598-021-99493-5lncRNA-disease association prediction based on latent factor model and projectionBo Wang0Chao Zhang1Xiao-xin Du2Jian-fei Zhang3College of Computer and Control Engineering, Qiqihar UniversityCollege of Computer and Control Engineering, Qiqihar UniversityCollege of Computer and Control Engineering, Qiqihar UniversityCollege of Computer and Control Engineering, Qiqihar UniversityAbstract Computer aided research of lncRNA-disease association is an important way to study the development of lncRNA-disease. The correlation analysis of existing data, the establishment of prediction model, prediction of unknown lncRNA-disease association, can make the biological experiment targeted, improve the accuracy of biological experiment. In this paper, a lncRNA-disease association prediction model based on latent factor model and projection is proposed (LFMP). This method uses lncRNA-miRNA association data and miRNA-disease association data to predict the unknown lncRNA-disease association, so this method does not need lncRNA-disease association data. The simulation results show that under the LOOCV framework, the AUC of LFMP can reach 0.8964. Better than the latest results. Through the case study of lung and colorectal tumors, LFMP can effectively infer the undetected lncRNA-disease association.https://doi.org/10.1038/s41598-021-99493-5 |
| spellingShingle | Bo Wang Chao Zhang Xiao-xin Du Jian-fei Zhang lncRNA-disease association prediction based on latent factor model and projection Scientific Reports |
| title | lncRNA-disease association prediction based on latent factor model and projection |
| title_full | lncRNA-disease association prediction based on latent factor model and projection |
| title_fullStr | lncRNA-disease association prediction based on latent factor model and projection |
| title_full_unstemmed | lncRNA-disease association prediction based on latent factor model and projection |
| title_short | lncRNA-disease association prediction based on latent factor model and projection |
| title_sort | lncrna disease association prediction based on latent factor model and projection |
| url | https://doi.org/10.1038/s41598-021-99493-5 |
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