Prognostic and Monitoring Value of Circulating Tumor Cells in Adrenocortical Carcinoma: A Preliminary Monocentric Study
Adrenocortical carcinoma (ACC), a rare and aggressive neoplasia, presents poor prognosis when metastatic at diagnosis and limited therapies are available. Specific and sensitive markers for early diagnosis and a monitoring system of therapy and tumor evolution are urgently needed. The liquid biopsy...
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MDPI AG
2020-10-01
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author | Giulia Cantini Letizia Canu Roberta Armignacco Francesca Salvianti Giuseppina De Filpo Tonino Ercolino Gabriella Nesi Mario Maggi Massimo Mannelli Pamela Pinzani Michaela Luconi |
author_facet | Giulia Cantini Letizia Canu Roberta Armignacco Francesca Salvianti Giuseppina De Filpo Tonino Ercolino Gabriella Nesi Mario Maggi Massimo Mannelli Pamela Pinzani Michaela Luconi |
author_sort | Giulia Cantini |
collection | DOAJ |
description | Adrenocortical carcinoma (ACC), a rare and aggressive neoplasia, presents poor prognosis when metastatic at diagnosis and limited therapies are available. Specific and sensitive markers for early diagnosis and a monitoring system of therapy and tumor evolution are urgently needed. The liquid biopsy represents a source of tumor material within a minimally invasive blood draw that allows the recovery of circulating tumor cells (CTCs). CTCs have been recently shown to be detectable in ACC. In the present paper, we evaluated the prognostic value of CTCs obtained by size-filtration in a small pilot cohort of 19 ACC patients. We found CTCs in 68% of pre-surgery and in 38% of post-surgery blood samples. In addition, CTC clusters (CTMs) and cancer associated macrophages (CAMLs) were detectable in some ACC patients. The median number of CTCs significantly decreased after the mass removal. Finally, stratifying patients in high and low pre-surgery CTC number groups, assuming the 75th percentile CTC value as cut-off, CTCs significantly predicted patients’ overall survival (log rank = 0.005), also in a multivariate analysis adjusted for age and tumor stage. In conclusion, though preliminary and performed in a small cohort of patients, our study suggests that CTC number may represent a promising marker for prognosis and disease monitoring in ACC. |
first_indexed | 2024-03-10T15:15:23Z |
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issn | 2072-6694 |
language | English |
last_indexed | 2024-03-10T15:15:23Z |
publishDate | 2020-10-01 |
publisher | MDPI AG |
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series | Cancers |
spelling | doaj.art-773f5ea5d5f046679fbf50aa9deee60c2023-11-20T18:58:55ZengMDPI AGCancers2072-66942020-10-011211317610.3390/cancers12113176Prognostic and Monitoring Value of Circulating Tumor Cells in Adrenocortical Carcinoma: A Preliminary Monocentric StudyGiulia Cantini0Letizia Canu1Roberta Armignacco2Francesca Salvianti3Giuseppina De Filpo4Tonino Ercolino5Gabriella Nesi6Mario Maggi7Massimo Mannelli8Pamela Pinzani9Michaela Luconi10Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, 50139 Florence, ItalyEndocrinology Unit, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, 50139 Florence, ItalyUniversité de Paris, Institut Cochin, INSERM, CNRS, F-75014 Paris, FranceEndocrinology Unit, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, 50139 Florence, ItalyEndocrinology Unit, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, 50139 Florence, ItalyCareggi University Hospital (AOUC), 50134 Florence, ItalyDivision of Pathological Anatomy, Department of Clinical and Experimental Medicine, University of Florence, 50134 Florence, ItalyEndocrinology Unit, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, 50139 Florence, ItalyEndocrinology Unit, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, 50139 Florence, ItalyEndocrinology Unit, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, 50139 Florence, ItalyEndocrinology Unit, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, 50139 Florence, ItalyAdrenocortical carcinoma (ACC), a rare and aggressive neoplasia, presents poor prognosis when metastatic at diagnosis and limited therapies are available. Specific and sensitive markers for early diagnosis and a monitoring system of therapy and tumor evolution are urgently needed. The liquid biopsy represents a source of tumor material within a minimally invasive blood draw that allows the recovery of circulating tumor cells (CTCs). CTCs have been recently shown to be detectable in ACC. In the present paper, we evaluated the prognostic value of CTCs obtained by size-filtration in a small pilot cohort of 19 ACC patients. We found CTCs in 68% of pre-surgery and in 38% of post-surgery blood samples. In addition, CTC clusters (CTMs) and cancer associated macrophages (CAMLs) were detectable in some ACC patients. The median number of CTCs significantly decreased after the mass removal. Finally, stratifying patients in high and low pre-surgery CTC number groups, assuming the 75th percentile CTC value as cut-off, CTCs significantly predicted patients’ overall survival (log rank = 0.005), also in a multivariate analysis adjusted for age and tumor stage. In conclusion, though preliminary and performed in a small cohort of patients, our study suggests that CTC number may represent a promising marker for prognosis and disease monitoring in ACC.https://www.mdpi.com/2072-6694/12/11/3176CTCsACCprognosisadrenocortical cancerliquid biopsycancer biomarker |
spellingShingle | Giulia Cantini Letizia Canu Roberta Armignacco Francesca Salvianti Giuseppina De Filpo Tonino Ercolino Gabriella Nesi Mario Maggi Massimo Mannelli Pamela Pinzani Michaela Luconi Prognostic and Monitoring Value of Circulating Tumor Cells in Adrenocortical Carcinoma: A Preliminary Monocentric Study Cancers CTCs ACC prognosis adrenocortical cancer liquid biopsy cancer biomarker |
title | Prognostic and Monitoring Value of Circulating Tumor Cells in Adrenocortical Carcinoma: A Preliminary Monocentric Study |
title_full | Prognostic and Monitoring Value of Circulating Tumor Cells in Adrenocortical Carcinoma: A Preliminary Monocentric Study |
title_fullStr | Prognostic and Monitoring Value of Circulating Tumor Cells in Adrenocortical Carcinoma: A Preliminary Monocentric Study |
title_full_unstemmed | Prognostic and Monitoring Value of Circulating Tumor Cells in Adrenocortical Carcinoma: A Preliminary Monocentric Study |
title_short | Prognostic and Monitoring Value of Circulating Tumor Cells in Adrenocortical Carcinoma: A Preliminary Monocentric Study |
title_sort | prognostic and monitoring value of circulating tumor cells in adrenocortical carcinoma a preliminary monocentric study |
topic | CTCs ACC prognosis adrenocortical cancer liquid biopsy cancer biomarker |
url | https://www.mdpi.com/2072-6694/12/11/3176 |
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