Metabolic Stress Drives Keratinocyte Defenses against Staphylococcus aureus Infection

Metabolic Stress Drives Keratinocyte Defenses against Staphylococcus aureus Infection

Human skin is commonly colonized and infected by Staphylococcus aureus. Exactly how these organisms are sensed by keratinocytes has not been clearly delineated. Using a combination of metabolic and transcriptomic methodologies, we found that S. aureus infection is sensed as a metabolic stress by the...

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Bibliographic Details
Main Authors: Matthew Wickersham, Sarah Wachtel, Tania Wong Fok Lung, Grace Soong, Rudy Jacquet, Anthony Richardson, Dane Parker, Alice Prince
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
HIF1α
keratinocytes
immunometabolism
glycolysis
Staphylococcus aureus
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471730253X

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