Albendazole-Induced SIRT3 Upregulation Protects Human Leukemia K562 Cells from the Cytotoxicity of MCL1 Suppression

Albendazole-Induced SIRT3 Upregulation Protects Human Leukemia K562 Cells from the Cytotoxicity of MCL1 Suppression

Previous studies have shown that MCL1 stabilization confers cancer cells resistance to microtubule targeting agents (MTAs) and functionally extends the lifespan of MTA-triggered mitotically arrested cells. Albendazole (ABZ), a benzimidazole anthelmintic, shows microtubule-destabilizing activity and...

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Bibliographic Details
Main Authors: Liang-Jun Wang, Li-Ren Liou, Yi-Jun Shi, Jing-Ting Chiou, Yuan-Chin Lee, Chia-Hui Huang, Po-Wei Huang, Long-Sen Chang
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
albendazole
leukemia
MCL1
SIRT3
apoptosis
Online Access:https://www.mdpi.com/1422-0067/21/11/3907

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