Long-Term Outcomes of Staged Revision Surgery for Chronic Periprosthetic Joint Infection of Total Hip Arthroplasty
Periprosthetic joint infection (PJI) is a serious complication of total hip arthroplasty. Staged revision surgery is considered effective in eradicating PJI. We aimed to determine the rate of infection resolution after each stage of staged revision surgery (first stage, repeat first stage, second st...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/1/122 |
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| author | Christopher W. Day Kerry Costi Susan Pannach Gerald J. Atkins Jochen G. Hofstaetter Stuart A. Callary Renjy Nelson Donald W. Howie Lucian B. Solomon |
| author_facet | Christopher W. Day Kerry Costi Susan Pannach Gerald J. Atkins Jochen G. Hofstaetter Stuart A. Callary Renjy Nelson Donald W. Howie Lucian B. Solomon |
| author_sort | Christopher W. Day |
| collection | DOAJ |
| description | Periprosthetic joint infection (PJI) is a serious complication of total hip arthroplasty. Staged revision surgery is considered effective in eradicating PJI. We aimed to determine the rate of infection resolution after each stage of staged revision surgery (first stage, repeat first stage, second stage, excision arthroplasty, and reimplantation) and to assess functional outcomes and the mortality rate at ten years in a consecutive series of 30 chronic PJI of total hip arthroplasties. Infection resolution was defined as no clinical nor laboratory evidence of infection at 24 months after the last surgery and after a minimum of 12 months following cessation of antimicrobial treatment. Four patients died within 24 months of their final surgery. Nineteen patients, 73% (worst-case analysis (wca) 63%), were infection free after 1 surgery; 22 patients, 85% (wca 73%), were infection free after 2 surgeries; and 26 patients, 100% (wca 87%), were infection free after three and four surgeries. The median Harris Hip Score was 41 prior to first revision surgery and improved to 74 at twelve months and 76 at ten years after the final surgery. Thirteen patients died at a mean of 64 months from first revision, giving a mortality rate of 43% at ten years, which is approximately 25% higher than that of an age-matched general population. The results show that with repeated aggressive surgical treatment, most PJIs of the hip are curable. Ten years after successful treatment of PJI, functional outcomes and pain are improved and maintained compared to before initial surgery, but this must be balanced against the high 10-year mortality. Level of evidence: cohort studies. |
| first_indexed | 2024-03-10T03:36:44Z |
| format | Article |
| id | doaj.art-774349690f5c4eb387d601222d7c8783 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T03:36:44Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-774349690f5c4eb387d601222d7c87832023-11-23T11:43:57ZengMDPI AGJournal of Clinical Medicine2077-03832021-12-0111112210.3390/jcm11010122Long-Term Outcomes of Staged Revision Surgery for Chronic Periprosthetic Joint Infection of Total Hip ArthroplastyChristopher W. Day0Kerry Costi1Susan Pannach2Gerald J. Atkins3Jochen G. Hofstaetter4Stuart A. Callary5Renjy Nelson6Donald W. Howie7Lucian B. Solomon8Department of Orthopaedics and Trauma, Royal Adelaide Hospital, Adelaide, SA 5000, AustraliaDepartment of Orthopaedics and Trauma, Royal Adelaide Hospital, Adelaide, SA 5000, AustraliaDepartment of Orthopaedics and Trauma, Royal Adelaide Hospital, Adelaide, SA 5000, AustraliaCentre for Orthopaedic and Trauma Research, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA 5005, AustraliaLudwig Boltzmann Institute of Osteology, Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1st Medical Department Hanusch Hospital, 1140 Vienna, AustriaDepartment of Orthopaedics and Trauma, Royal Adelaide Hospital, Adelaide, SA 5000, AustraliaDepartment of Infectious Diseases, Royal Adelaide Hospital, Adelaide, SA 5000, AustraliaDepartment of Orthopaedics and Trauma, Royal Adelaide Hospital, Adelaide, SA 5000, AustraliaDepartment of Orthopaedics and Trauma, Royal Adelaide Hospital, Adelaide, SA 5000, AustraliaPeriprosthetic joint infection (PJI) is a serious complication of total hip arthroplasty. Staged revision surgery is considered effective in eradicating PJI. We aimed to determine the rate of infection resolution after each stage of staged revision surgery (first stage, repeat first stage, second stage, excision arthroplasty, and reimplantation) and to assess functional outcomes and the mortality rate at ten years in a consecutive series of 30 chronic PJI of total hip arthroplasties. Infection resolution was defined as no clinical nor laboratory evidence of infection at 24 months after the last surgery and after a minimum of 12 months following cessation of antimicrobial treatment. Four patients died within 24 months of their final surgery. Nineteen patients, 73% (worst-case analysis (wca) 63%), were infection free after 1 surgery; 22 patients, 85% (wca 73%), were infection free after 2 surgeries; and 26 patients, 100% (wca 87%), were infection free after three and four surgeries. The median Harris Hip Score was 41 prior to first revision surgery and improved to 74 at twelve months and 76 at ten years after the final surgery. Thirteen patients died at a mean of 64 months from first revision, giving a mortality rate of 43% at ten years, which is approximately 25% higher than that of an age-matched general population. The results show that with repeated aggressive surgical treatment, most PJIs of the hip are curable. Ten years after successful treatment of PJI, functional outcomes and pain are improved and maintained compared to before initial surgery, but this must be balanced against the high 10-year mortality. Level of evidence: cohort studies.https://www.mdpi.com/2077-0383/11/1/122total hip arthroplastyperiprosthetic joint infection (PJI)eradicationtwo-stage revisionfunctional outcomesmortality |
| spellingShingle | Christopher W. Day Kerry Costi Susan Pannach Gerald J. Atkins Jochen G. Hofstaetter Stuart A. Callary Renjy Nelson Donald W. Howie Lucian B. Solomon Long-Term Outcomes of Staged Revision Surgery for Chronic Periprosthetic Joint Infection of Total Hip Arthroplasty Journal of Clinical Medicine total hip arthroplasty periprosthetic joint infection (PJI) eradication two-stage revision functional outcomes mortality |
| title | Long-Term Outcomes of Staged Revision Surgery for Chronic Periprosthetic Joint Infection of Total Hip Arthroplasty |
| title_full | Long-Term Outcomes of Staged Revision Surgery for Chronic Periprosthetic Joint Infection of Total Hip Arthroplasty |
| title_fullStr | Long-Term Outcomes of Staged Revision Surgery for Chronic Periprosthetic Joint Infection of Total Hip Arthroplasty |
| title_full_unstemmed | Long-Term Outcomes of Staged Revision Surgery for Chronic Periprosthetic Joint Infection of Total Hip Arthroplasty |
| title_short | Long-Term Outcomes of Staged Revision Surgery for Chronic Periprosthetic Joint Infection of Total Hip Arthroplasty |
| title_sort | long term outcomes of staged revision surgery for chronic periprosthetic joint infection of total hip arthroplasty |
| topic | total hip arthroplasty periprosthetic joint infection (PJI) eradication two-stage revision functional outcomes mortality |
| url | https://www.mdpi.com/2077-0383/11/1/122 |
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