Evaluation of micronuclei in oral mucosa of individuals exposed to ionizing radiation: a pilot study from Celaya, México
Introduction: Occupational exposure to ionizing radiation can potentially lead to adverse health effects, including cancer and genetic defects. Genetic damage caused by radiation can be detected if micronuclei are observed. The objective of this pilot study was to detect the presence of micronuclei...
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| Format: | Article |
| Language: | English |
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University Library System, University of Pittsburgh
2019-05-01
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| Series: | Central Asian Journal of Global Health |
| Subjects: | |
| Online Access: | http://cajgh.pitt.edu/ojs/index.php/cajgh/article/view/331 |
| _version_ | 1818129238712123392 |
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| author | Nicolas Padilla-Raygoza María del Rocio Adame Gutiérrez Itza Zelene Moreno Martínez Vicente Beltran-Campos Silvia del Carmen Delgado-Sandoval Maria de Lourdes Garcia-Campos Modesto Antonio Sosa-Aquino Teodoro Cordova-Fraga Rafael Guzman-Cabrera |
| author_facet | Nicolas Padilla-Raygoza María del Rocio Adame Gutiérrez Itza Zelene Moreno Martínez Vicente Beltran-Campos Silvia del Carmen Delgado-Sandoval Maria de Lourdes Garcia-Campos Modesto Antonio Sosa-Aquino Teodoro Cordova-Fraga Rafael Guzman-Cabrera |
| author_sort | Nicolas Padilla-Raygoza |
| collection | DOAJ |
| description | Introduction: Occupational exposure to ionizing radiation can potentially lead to adverse health effects, including cancer and genetic defects. Genetic damage caused by radiation can be detected if micronuclei are observed. The objective of this pilot study was to detect the presence of micronuclei in cells of the oral mucosa in inidividuals occupationally exposed to ionizing radiation.
Methods: We implemented a pilot case-control study in which we compared oral mucosa micronuclei in 30 medical and nursing personnel in radiology centers in Celaya, Mexico, with 30 volunteers not exposed to ionizing radiation recruited from a public University. The oral mucosa was brushed and the amount of micronuclei was quantified. Chi-square test or t-test for two proportions were used to compared ionizing radiation and genetic damage between exposed and non-exposed groups.
Results: The exposed group had an average of 5.37 ± 3.49 micronuclei and the non-exposed had 0.37 ± 0.61 (P<0.01). In the exposed group, 90% of participants exhibited genetic damage compared to 6.67% in the unexposed group (P<0.05).
Conclusion: In this pilot study, medical and nursing staff from radiology centers presented with higher genetic damage compared to control group. Further studies are needed to identify the prevalence of genetic damage due to occupational radiation exposure in Mexico. |
| first_indexed | 2024-12-11T07:45:58Z |
| format | Article |
| id | doaj.art-77453bf4ba8d4990a94d719a1b041069 |
| institution | Directory Open Access Journal |
| issn | 2166-7403 |
| language | English |
| last_indexed | 2024-12-11T07:45:58Z |
| publishDate | 2019-05-01 |
| publisher | University Library System, University of Pittsburgh |
| record_format | Article |
| series | Central Asian Journal of Global Health |
| spelling | doaj.art-77453bf4ba8d4990a94d719a1b0410692022-12-22T01:15:28ZengUniversity Library System, University of PittsburghCentral Asian Journal of Global Health2166-74032019-05-018110.5195/cajgh.2019.331165Evaluation of micronuclei in oral mucosa of individuals exposed to ionizing radiation: a pilot study from Celaya, MéxicoNicolas Padilla-Raygoza0María del Rocio Adame Gutiérrez1Itza Zelene Moreno Martínez2Vicente Beltran-Campos3Silvia del Carmen Delgado-Sandoval4Maria de Lourdes Garcia-Campos5Modesto Antonio Sosa-Aquino6Teodoro Cordova-Fraga7Rafael Guzman-Cabrera8Department of Nursing and Obstetrics, Division of Health Sciences and Engineering, Universidad of Guanajuato Mutualismo, MéxicoAcademic Unity of Nursing N°1, University Autonomous of Guerrero, MéxicoDivision of Health Sciences and Engineering, University of Guanajuato, MéxicoDepartment of Clinical Nursing, Division of Health Sciences and Engineering, University of Guanajuato, MéxicoDepartment of Nursing and Obstetrics, Division of Health Sciences and Engineering, Universidad of Guanajuato Mutualismo, MéxicoDepartment of Clinical Nursing, Division of Health Sciences and Engineering, University of Guanajuato, MéxicoDepartment oh Physical Engineering, Division of Sciences and Engineering, University of Guanajuato, MéxicoDepartment oh Physical Engineering, Division of Sciences and Engineering, University of Guanajuato, MéxicoDepartmentof Electrical Engineering, Division of Engineerings, University of Guanajuato, MéxicoIntroduction: Occupational exposure to ionizing radiation can potentially lead to adverse health effects, including cancer and genetic defects. Genetic damage caused by radiation can be detected if micronuclei are observed. The objective of this pilot study was to detect the presence of micronuclei in cells of the oral mucosa in inidividuals occupationally exposed to ionizing radiation. Methods: We implemented a pilot case-control study in which we compared oral mucosa micronuclei in 30 medical and nursing personnel in radiology centers in Celaya, Mexico, with 30 volunteers not exposed to ionizing radiation recruited from a public University. The oral mucosa was brushed and the amount of micronuclei was quantified. Chi-square test or t-test for two proportions were used to compared ionizing radiation and genetic damage between exposed and non-exposed groups. Results: The exposed group had an average of 5.37 ± 3.49 micronuclei and the non-exposed had 0.37 ± 0.61 (P<0.01). In the exposed group, 90% of participants exhibited genetic damage compared to 6.67% in the unexposed group (P<0.05). Conclusion: In this pilot study, medical and nursing staff from radiology centers presented with higher genetic damage compared to control group. Further studies are needed to identify the prevalence of genetic damage due to occupational radiation exposure in Mexico.http://cajgh.pitt.edu/ojs/index.php/cajgh/article/view/331Ionizing RadiationMicronucleiGenetic Damage |
| spellingShingle | Nicolas Padilla-Raygoza María del Rocio Adame Gutiérrez Itza Zelene Moreno Martínez Vicente Beltran-Campos Silvia del Carmen Delgado-Sandoval Maria de Lourdes Garcia-Campos Modesto Antonio Sosa-Aquino Teodoro Cordova-Fraga Rafael Guzman-Cabrera Evaluation of micronuclei in oral mucosa of individuals exposed to ionizing radiation: a pilot study from Celaya, México Central Asian Journal of Global Health Ionizing Radiation Micronuclei Genetic Damage |
| title | Evaluation of micronuclei in oral mucosa of individuals exposed to ionizing radiation: a pilot study from Celaya, México |
| title_full | Evaluation of micronuclei in oral mucosa of individuals exposed to ionizing radiation: a pilot study from Celaya, México |
| title_fullStr | Evaluation of micronuclei in oral mucosa of individuals exposed to ionizing radiation: a pilot study from Celaya, México |
| title_full_unstemmed | Evaluation of micronuclei in oral mucosa of individuals exposed to ionizing radiation: a pilot study from Celaya, México |
| title_short | Evaluation of micronuclei in oral mucosa of individuals exposed to ionizing radiation: a pilot study from Celaya, México |
| title_sort | evaluation of micronuclei in oral mucosa of individuals exposed to ionizing radiation a pilot study from celaya mexico |
| topic | Ionizing Radiation Micronuclei Genetic Damage |
| url | http://cajgh.pitt.edu/ojs/index.php/cajgh/article/view/331 |
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