Effect of polyunsaturated fatty acids on proliferation and survival of prostate cancer cells.
Progression of prostate cancer to lethal forms is marked by emergence of hormone-independent proliferation of the cancer cells. Nutritional and epidemiological studies have indicated that prostate cancer progression is correlated with the consumption of polyunsaturated fatty acids (PUFA). To shed ad...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0219822 |
| _version_ | 1818581274877493248 |
|---|---|
| author | Brenden A Bratton Ivan V Maly Wilma A Hofmann |
| author_facet | Brenden A Bratton Ivan V Maly Wilma A Hofmann |
| author_sort | Brenden A Bratton |
| collection | DOAJ |
| description | Progression of prostate cancer to lethal forms is marked by emergence of hormone-independent proliferation of the cancer cells. Nutritional and epidemiological studies have indicated that prostate cancer progression is correlated with the consumption of polyunsaturated fatty acids (PUFA). To shed additional light on the cell-level mechanisms of the observed correlation, we compared the sensitivity of hormone-dependent and hormone-independent prostate cancer cells to growth medium supplementation with free PUFAs in a cell proliferation and viability assay. Our data show that the hormone-dependent cells are comparatively insensitive to various PUFAs, at the same time as the growth and viability of hormone-independent cells lines are strongly inhibited by most of the tested PUFAs, whether n-3 or n-6. We speculate that this difference may be at least partially responsible for the observed effects of specific dietary lipids in prostate cancer. The new data strengthen the case for dietary intervention as part of potential new therapeutic strategies seeking to impede prostate cancer progression. |
| first_indexed | 2024-12-16T07:30:54Z |
| format | Article |
| id | doaj.art-774877a75dfd4c379f96fad4524abfe6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T07:30:54Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-774877a75dfd4c379f96fad4524abfe62022-12-21T22:39:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01147e021982210.1371/journal.pone.0219822Effect of polyunsaturated fatty acids on proliferation and survival of prostate cancer cells.Brenden A BrattonIvan V MalyWilma A HofmannProgression of prostate cancer to lethal forms is marked by emergence of hormone-independent proliferation of the cancer cells. Nutritional and epidemiological studies have indicated that prostate cancer progression is correlated with the consumption of polyunsaturated fatty acids (PUFA). To shed additional light on the cell-level mechanisms of the observed correlation, we compared the sensitivity of hormone-dependent and hormone-independent prostate cancer cells to growth medium supplementation with free PUFAs in a cell proliferation and viability assay. Our data show that the hormone-dependent cells are comparatively insensitive to various PUFAs, at the same time as the growth and viability of hormone-independent cells lines are strongly inhibited by most of the tested PUFAs, whether n-3 or n-6. We speculate that this difference may be at least partially responsible for the observed effects of specific dietary lipids in prostate cancer. The new data strengthen the case for dietary intervention as part of potential new therapeutic strategies seeking to impede prostate cancer progression.https://doi.org/10.1371/journal.pone.0219822 |
| spellingShingle | Brenden A Bratton Ivan V Maly Wilma A Hofmann Effect of polyunsaturated fatty acids on proliferation and survival of prostate cancer cells. PLoS ONE |
| title | Effect of polyunsaturated fatty acids on proliferation and survival of prostate cancer cells. |
| title_full | Effect of polyunsaturated fatty acids on proliferation and survival of prostate cancer cells. |
| title_fullStr | Effect of polyunsaturated fatty acids on proliferation and survival of prostate cancer cells. |
| title_full_unstemmed | Effect of polyunsaturated fatty acids on proliferation and survival of prostate cancer cells. |
| title_short | Effect of polyunsaturated fatty acids on proliferation and survival of prostate cancer cells. |
| title_sort | effect of polyunsaturated fatty acids on proliferation and survival of prostate cancer cells |
| url | https://doi.org/10.1371/journal.pone.0219822 |
| work_keys_str_mv | AT brendenabratton effectofpolyunsaturatedfattyacidsonproliferationandsurvivalofprostatecancercells AT ivanvmaly effectofpolyunsaturatedfattyacidsonproliferationandsurvivalofprostatecancercells AT wilmaahofmann effectofpolyunsaturatedfattyacidsonproliferationandsurvivalofprostatecancercells |