Utility of 1,2‐o‐dilauryl‐rac‐glycero glutaric acid‐(6′‐methylresorufin)‐ester‐lipase for monitoring dogs with chronic pancreatitis
Abstract Background The utility of 1,2‐o‐dilauryl‐rac‐glycero glutaric acid‐(6′‐methylresorufin)‐ester‐(DGGR)‐lipase activity (DLA) in monitoring clinical progression of chronic pancreatitis (CP) in dogs is unknown. Objective To examine the association of DLA with clinical signs of CP, as assessed b...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.16638 |
| _version_ | 1797856217690800128 |
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| author | Sharon Kuzi Dana Adlersberg Itamar Aroch Gilad Segev |
| author_facet | Sharon Kuzi Dana Adlersberg Itamar Aroch Gilad Segev |
| author_sort | Sharon Kuzi |
| collection | DOAJ |
| description | Abstract Background The utility of 1,2‐o‐dilauryl‐rac‐glycero glutaric acid‐(6′‐methylresorufin)‐ester‐(DGGR)‐lipase activity (DLA) in monitoring clinical progression of chronic pancreatitis (CP) in dogs is unknown. Objective To examine the association of DLA with clinical signs of CP, as assessed by a CP clinical severity score (CPCSS). Animals: Twenty‐four dogs. Methods This is a retrospective study. Chronic pancreatitis was diagnosed based on clinical signs and DLA > 250 U/L and monitored using CPCSS and DLA. Results The study included 134 visits (median, 10 visits/dog; range, 2‐11). Mild‐moderate (CPCSS, 0‐3) and severe (CPCSS, ≥4) disease were documented in 94 (70%) and 40 (30%) visits, respectively. In emergency visits (n = 44; 33%) CPCSS (median, 5; range, 0‐15) and DLA (median, 534 U/L; range, 63‐7133) were higher (P < .001 and P = .003, respectively) than in scheduled ones (n = 90; 67%; median, 1; range, 0‐6 and median, 384 U/L; range, 49‐3747, respectively). DGGR‐lipase activity was associated (P = .009) with the CPCSS, with a lower activity documented in mild‐moderate CPCSS (median 391 U/L; range, 49‐3747), compared to severe score (median, 558 U/L; range, 63‐7133). DGGR‐lipase activity was significantly, but weakly, correlated with CPSS (r = 0.233, P = .007). DGGR‐lipase activity inefficiently discriminated mild‐moderate vs severe CP (area under the receiver operator characteristics curve, 0.64; 95% confidence interval, 0.53‐0.75; P = .012), with DLA cutoff of 428 U/L corresponding to sensitivity of 65% and specificity of 63%. Conclusions and Clinical Importance Increased DLA is associated with emergency revisits in dogs with CP, possibly reflecting acute flare‐ups. DGGR‐lipase activity was associated with the CPCSS over the follow‐ups but could not differentiate disease severity. |
| first_indexed | 2024-04-09T20:36:50Z |
| format | Article |
| id | doaj.art-774c4efced754709816ec83c1abb87dc |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-09T20:36:50Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-774c4efced754709816ec83c1abb87dc2023-03-30T07:47:05ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762023-03-0137243744510.1111/jvim.16638Utility of 1,2‐o‐dilauryl‐rac‐glycero glutaric acid‐(6′‐methylresorufin)‐ester‐lipase for monitoring dogs with chronic pancreatitisSharon Kuzi0Dana Adlersberg1Itamar Aroch2Gilad Segev3Department of Small Animals Internal Medicine Hebrew University Veterinary Teaching Hospital and Koret School of Veterinary Medicine, Hebrew University of Jerusalem Rehovot 761001 IsraelDepartment of Small Animals Internal Medicine Hebrew University Veterinary Teaching Hospital and Koret School of Veterinary Medicine, Hebrew University of Jerusalem Rehovot 761001 IsraelDepartment of Small Animals Internal Medicine Hebrew University Veterinary Teaching Hospital and Koret School of Veterinary Medicine, Hebrew University of Jerusalem Rehovot 761001 IsraelDepartment of Small Animals Internal Medicine Hebrew University Veterinary Teaching Hospital and Koret School of Veterinary Medicine, Hebrew University of Jerusalem Rehovot 761001 IsraelAbstract Background The utility of 1,2‐o‐dilauryl‐rac‐glycero glutaric acid‐(6′‐methylresorufin)‐ester‐(DGGR)‐lipase activity (DLA) in monitoring clinical progression of chronic pancreatitis (CP) in dogs is unknown. Objective To examine the association of DLA with clinical signs of CP, as assessed by a CP clinical severity score (CPCSS). Animals: Twenty‐four dogs. Methods This is a retrospective study. Chronic pancreatitis was diagnosed based on clinical signs and DLA > 250 U/L and monitored using CPCSS and DLA. Results The study included 134 visits (median, 10 visits/dog; range, 2‐11). Mild‐moderate (CPCSS, 0‐3) and severe (CPCSS, ≥4) disease were documented in 94 (70%) and 40 (30%) visits, respectively. In emergency visits (n = 44; 33%) CPCSS (median, 5; range, 0‐15) and DLA (median, 534 U/L; range, 63‐7133) were higher (P < .001 and P = .003, respectively) than in scheduled ones (n = 90; 67%; median, 1; range, 0‐6 and median, 384 U/L; range, 49‐3747, respectively). DGGR‐lipase activity was associated (P = .009) with the CPCSS, with a lower activity documented in mild‐moderate CPCSS (median 391 U/L; range, 49‐3747), compared to severe score (median, 558 U/L; range, 63‐7133). DGGR‐lipase activity was significantly, but weakly, correlated with CPSS (r = 0.233, P = .007). DGGR‐lipase activity inefficiently discriminated mild‐moderate vs severe CP (area under the receiver operator characteristics curve, 0.64; 95% confidence interval, 0.53‐0.75; P = .012), with DLA cutoff of 428 U/L corresponding to sensitivity of 65% and specificity of 63%. Conclusions and Clinical Importance Increased DLA is associated with emergency revisits in dogs with CP, possibly reflecting acute flare‐ups. DGGR‐lipase activity was associated with the CPCSS over the follow‐ups but could not differentiate disease severity.https://doi.org/10.1111/jvim.16638abdominal painacute on chronic pancreatitiscanineDGGR‐lipase |
| spellingShingle | Sharon Kuzi Dana Adlersberg Itamar Aroch Gilad Segev Utility of 1,2‐o‐dilauryl‐rac‐glycero glutaric acid‐(6′‐methylresorufin)‐ester‐lipase for monitoring dogs with chronic pancreatitis Journal of Veterinary Internal Medicine abdominal pain acute on chronic pancreatitis canine DGGR‐lipase |
| title | Utility of 1,2‐o‐dilauryl‐rac‐glycero glutaric acid‐(6′‐methylresorufin)‐ester‐lipase for monitoring dogs with chronic pancreatitis |
| title_full | Utility of 1,2‐o‐dilauryl‐rac‐glycero glutaric acid‐(6′‐methylresorufin)‐ester‐lipase for monitoring dogs with chronic pancreatitis |
| title_fullStr | Utility of 1,2‐o‐dilauryl‐rac‐glycero glutaric acid‐(6′‐methylresorufin)‐ester‐lipase for monitoring dogs with chronic pancreatitis |
| title_full_unstemmed | Utility of 1,2‐o‐dilauryl‐rac‐glycero glutaric acid‐(6′‐methylresorufin)‐ester‐lipase for monitoring dogs with chronic pancreatitis |
| title_short | Utility of 1,2‐o‐dilauryl‐rac‐glycero glutaric acid‐(6′‐methylresorufin)‐ester‐lipase for monitoring dogs with chronic pancreatitis |
| title_sort | utility of 1 2 o dilauryl rac glycero glutaric acid 6 methylresorufin ester lipase for monitoring dogs with chronic pancreatitis |
| topic | abdominal pain acute on chronic pancreatitis canine DGGR‐lipase |
| url | https://doi.org/10.1111/jvim.16638 |
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