Gastroesophageal Reflux in Children with Asthma
Background: Nowadays it is considered that a specific causal relationship exists between asthma and gastroesophageal reflux (GER), because of the aspiration of gastric refluate which leads to and maintain spasticity even real crisis of paroxystic expiratory dyspnea. This study explores this relation...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-03-01
|
| Series: | Children |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9067/9/3/336 |
| _version_ | 1797472312521392128 |
|---|---|
| author | Vasile Valeriu Lupu Ingrith Miron Elena Tarca Laura Mihaela Trandafir Dana-Teodora Anton-Paduraru Stefana Maria Moisa Magdalena Starcea Andrei Cernomaz Lucian Miron Ancuta Lupu |
| author_facet | Vasile Valeriu Lupu Ingrith Miron Elena Tarca Laura Mihaela Trandafir Dana-Teodora Anton-Paduraru Stefana Maria Moisa Magdalena Starcea Andrei Cernomaz Lucian Miron Ancuta Lupu |
| author_sort | Vasile Valeriu Lupu |
| collection | DOAJ |
| description | Background: Nowadays it is considered that a specific causal relationship exists between asthma and gastroesophageal reflux (GER), because of the aspiration of gastric refluate which leads to and maintain spasticity even real crisis of paroxystic expiratory dyspnea. This study explores this relationship and evaluates the results after treatment. Methods: 56 children diagnosed with asthma, hospitalized in a regional center of pediatric gastroenterology in Northeast Romania, underwent 24-hour continuous esophageal pH monitoring in order to establish the presence of GER. The Boix-Ochoa score was used to interpret the results. Proton pump inhibitors were administered to those with GER and the patients were reevaluated after 2 months. Results: 39 patients (69.64%) had GER, with a Boix-Ochoa score above normal (N < 11.99), and 17 patients (30.36%) had normal score. After administering proton pump inhibitors for 2 months, 7 patients still had high Boix-Ochoa score (17.95%). The result of this analysis shows that the presence of asthma increases the chance of GER by 2.86 times. Conclusions: In children with asthma we have to look for GER in order to treat, because it can help the treatment of asthma or even solve some cases resistant to standard treatment. |
| first_indexed | 2024-03-09T20:00:04Z |
| format | Article |
| id | doaj.art-774edfa26e2f406a8457f37b70639a29 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T20:00:04Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-774edfa26e2f406a8457f37b70639a292023-11-24T00:46:41ZengMDPI AGChildren2227-90672022-03-019333610.3390/children9030336Gastroesophageal Reflux in Children with AsthmaVasile Valeriu Lupu0Ingrith Miron1Elena Tarca2Laura Mihaela Trandafir3Dana-Teodora Anton-Paduraru4Stefana Maria Moisa5Magdalena Starcea6Andrei Cernomaz7Lucian Miron8Ancuta Lupu9Pediatrics Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Surgery II—Pediatric Surgery, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania3rd Medical Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania3rd Medical Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaBackground: Nowadays it is considered that a specific causal relationship exists between asthma and gastroesophageal reflux (GER), because of the aspiration of gastric refluate which leads to and maintain spasticity even real crisis of paroxystic expiratory dyspnea. This study explores this relationship and evaluates the results after treatment. Methods: 56 children diagnosed with asthma, hospitalized in a regional center of pediatric gastroenterology in Northeast Romania, underwent 24-hour continuous esophageal pH monitoring in order to establish the presence of GER. The Boix-Ochoa score was used to interpret the results. Proton pump inhibitors were administered to those with GER and the patients were reevaluated after 2 months. Results: 39 patients (69.64%) had GER, with a Boix-Ochoa score above normal (N < 11.99), and 17 patients (30.36%) had normal score. After administering proton pump inhibitors for 2 months, 7 patients still had high Boix-Ochoa score (17.95%). The result of this analysis shows that the presence of asthma increases the chance of GER by 2.86 times. Conclusions: In children with asthma we have to look for GER in order to treat, because it can help the treatment of asthma or even solve some cases resistant to standard treatment.https://www.mdpi.com/2227-9067/9/3/336gastroesophageal refluxasthma24 h esophageal pH-metryBoix-Ochoa scorechildren |
| spellingShingle | Vasile Valeriu Lupu Ingrith Miron Elena Tarca Laura Mihaela Trandafir Dana-Teodora Anton-Paduraru Stefana Maria Moisa Magdalena Starcea Andrei Cernomaz Lucian Miron Ancuta Lupu Gastroesophageal Reflux in Children with Asthma Children gastroesophageal reflux asthma 24 h esophageal pH-metry Boix-Ochoa score children |
| title | Gastroesophageal Reflux in Children with Asthma |
| title_full | Gastroesophageal Reflux in Children with Asthma |
| title_fullStr | Gastroesophageal Reflux in Children with Asthma |
| title_full_unstemmed | Gastroesophageal Reflux in Children with Asthma |
| title_short | Gastroesophageal Reflux in Children with Asthma |
| title_sort | gastroesophageal reflux in children with asthma |
| topic | gastroesophageal reflux asthma 24 h esophageal pH-metry Boix-Ochoa score children |
| url | https://www.mdpi.com/2227-9067/9/3/336 |
| work_keys_str_mv | AT vasilevaleriulupu gastroesophagealrefluxinchildrenwithasthma AT ingrithmiron gastroesophagealrefluxinchildrenwithasthma AT elenatarca gastroesophagealrefluxinchildrenwithasthma AT lauramihaelatrandafir gastroesophagealrefluxinchildrenwithasthma AT danateodoraantonpaduraru gastroesophagealrefluxinchildrenwithasthma AT stefanamariamoisa gastroesophagealrefluxinchildrenwithasthma AT magdalenastarcea gastroesophagealrefluxinchildrenwithasthma AT andreicernomaz gastroesophagealrefluxinchildrenwithasthma AT lucianmiron gastroesophagealrefluxinchildrenwithasthma AT ancutalupu gastroesophagealrefluxinchildrenwithasthma |