Recent advances in engineering of tooth and tooth structures using postnatal dental cells

Since cells isolated from the developing tooth possess an enormous regenerative potential, it has been proposed that they could be applied to the in vivo regeneration of teeth in dental practice. The generation of the entire tooth structure depends upon the developmental stage of tooth when the cell...

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Main Authors: Masaki J. Honda, Shuhei Tsuchiya, Yoshinori Shinohara, Yuka Shinmura, Yoshinori Sumita
Format: Article
Language:English
Published: Elsevier 2010-02-01
Series:Japanese Dental Science Review
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1882761609000854
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author Masaki J. Honda
Shuhei Tsuchiya
Yoshinori Shinohara
Yuka Shinmura
Yoshinori Sumita
author_facet Masaki J. Honda
Shuhei Tsuchiya
Yoshinori Shinohara
Yuka Shinmura
Yoshinori Sumita
author_sort Masaki J. Honda
collection DOAJ
description Since cells isolated from the developing tooth possess an enormous regenerative potential, it has been proposed that they could be applied to the in vivo regeneration of teeth in dental practice. The generation of the entire tooth structure depends upon the developmental stage of tooth when the cells are harvested. This review focuses on the performance of postnatal and adult dental cells that have been used for generating teeth. Their ability to contribute to tooth development was assessed in the omentum or in the tooth socket. Adult dental cells were limited in their potential owing to various parameters. From these results described, new approaches for regenerated teeth are proposed in this review. One strategy to replace teeth is tooth root engineering using tissue from postnatal teeth. Since the enamel organ epithelium disappears after tooth maturation, the epithelial rest cells of Malassez were evaluated to determine their capacity to generate enamel. From these results, it is suggested that erupted mature teeth have cell sources with the capacity to produce tooth root. The development of biological approaches for tooth root regeneration using postnatal dental cells is promising and remains one of the greatest challenges in the dental field in the years to come.
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spelling doaj.art-774fc9d82eed4dedae6ebdc392cab9ee2022-12-22T00:43:22ZengElsevierJapanese Dental Science Review1882-76162010-02-01461546610.1016/j.jdsr.2009.10.006Recent advances in engineering of tooth and tooth structures using postnatal dental cellsMasaki J. Honda0Shuhei Tsuchiya1Yoshinori Shinohara2Yuka Shinmura3Yoshinori Sumita4Department of Anatomy, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8310, JapanDepartment of Anatomy, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8310, JapanDivision of Stem Cell Engineering, The Institute of Medical Science, The University of Tokyo, JapanDivision of Stem Cell Engineering, The Institute of Medical Science, The University of Tokyo, JapanDivision of Stem Cell Engineering, The Institute of Medical Science, The University of Tokyo, JapanSince cells isolated from the developing tooth possess an enormous regenerative potential, it has been proposed that they could be applied to the in vivo regeneration of teeth in dental practice. The generation of the entire tooth structure depends upon the developmental stage of tooth when the cells are harvested. This review focuses on the performance of postnatal and adult dental cells that have been used for generating teeth. Their ability to contribute to tooth development was assessed in the omentum or in the tooth socket. Adult dental cells were limited in their potential owing to various parameters. From these results described, new approaches for regenerated teeth are proposed in this review. One strategy to replace teeth is tooth root engineering using tissue from postnatal teeth. Since the enamel organ epithelium disappears after tooth maturation, the epithelial rest cells of Malassez were evaluated to determine their capacity to generate enamel. From these results, it is suggested that erupted mature teeth have cell sources with the capacity to produce tooth root. The development of biological approaches for tooth root regeneration using postnatal dental cells is promising and remains one of the greatest challenges in the dental field in the years to come.http://www.sciencedirect.com/science/article/pii/S1882761609000854Enamel-tissue engineeringPostnatal dental cellsStem cellsTissue engineeringTooth regenerationTooth root engineering
spellingShingle Masaki J. Honda
Shuhei Tsuchiya
Yoshinori Shinohara
Yuka Shinmura
Yoshinori Sumita
Recent advances in engineering of tooth and tooth structures using postnatal dental cells
Japanese Dental Science Review
Enamel-tissue engineering
Postnatal dental cells
Stem cells
Tissue engineering
Tooth regeneration
Tooth root engineering
title Recent advances in engineering of tooth and tooth structures using postnatal dental cells
title_full Recent advances in engineering of tooth and tooth structures using postnatal dental cells
title_fullStr Recent advances in engineering of tooth and tooth structures using postnatal dental cells
title_full_unstemmed Recent advances in engineering of tooth and tooth structures using postnatal dental cells
title_short Recent advances in engineering of tooth and tooth structures using postnatal dental cells
title_sort recent advances in engineering of tooth and tooth structures using postnatal dental cells
topic Enamel-tissue engineering
Postnatal dental cells
Stem cells
Tissue engineering
Tooth regeneration
Tooth root engineering
url http://www.sciencedirect.com/science/article/pii/S1882761609000854
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