Bifunctionalized Gold Nanoparticles for the Colorimetric Detection of the Drug γ-Hydroxybutyric Acid (GHB) in Beverages
The increase in the number of drug-facilitated sexual assault (DFSA) cases in recent years has become a major concern. Consequently, there is a need to develop methods for the real-time detection of these substances. We report herein a colorimetric chemosensor for the real-time in situ detection of...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/9/7/160 |
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| author | Silvia Rodríguez-Nuévalos Ana M. Costero Salvador Gil Margarita Parra Pablo Gaviña |
| author_facet | Silvia Rodríguez-Nuévalos Ana M. Costero Salvador Gil Margarita Parra Pablo Gaviña |
| author_sort | Silvia Rodríguez-Nuévalos |
| collection | DOAJ |
| description | The increase in the number of drug-facilitated sexual assault (DFSA) cases in recent years has become a major concern. Consequently, there is a need to develop methods for the real-time detection of these substances. We report herein a colorimetric chemosensor for the real-time in situ detection of the “date rape” drug GHB. The sensor is based on gold nanoparticles functionalized with both a 2-aminonaphthoxazole and phenanthroline derivative. Its ability to act as “naked-eye” colorimetric sensor for the detection of the drug in soft drinks and alcoholic beverages was studied. The detection process is based on the double recognition of both the hydroxyl and the carboxylate groups present in GHB, which triggers the aggregation of the AuNPs, with the resulting change in the color of the solution. |
| first_indexed | 2024-03-10T10:02:41Z |
| format | Article |
| id | doaj.art-7753c1fe54584954947e60d01d4dbcf5 |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-03-10T10:02:41Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-7753c1fe54584954947e60d01d4dbcf52023-11-22T01:49:21ZengMDPI AGChemosensors2227-90402021-06-019716010.3390/chemosensors9070160Bifunctionalized Gold Nanoparticles for the Colorimetric Detection of the Drug γ-Hydroxybutyric Acid (GHB) in BeveragesSilvia Rodríguez-Nuévalos0Ana M. Costero1Salvador Gil2Margarita Parra3Pablo Gaviña4Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitad Politècnica de València, Universitat de València, Doctor Moliner 50, 46100 Burjassot, SpainInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitad Politècnica de València, Universitat de València, Doctor Moliner 50, 46100 Burjassot, SpainInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitad Politècnica de València, Universitat de València, Doctor Moliner 50, 46100 Burjassot, SpainInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitad Politècnica de València, Universitat de València, Doctor Moliner 50, 46100 Burjassot, SpainInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitad Politècnica de València, Universitat de València, Doctor Moliner 50, 46100 Burjassot, SpainThe increase in the number of drug-facilitated sexual assault (DFSA) cases in recent years has become a major concern. Consequently, there is a need to develop methods for the real-time detection of these substances. We report herein a colorimetric chemosensor for the real-time in situ detection of the “date rape” drug GHB. The sensor is based on gold nanoparticles functionalized with both a 2-aminonaphthoxazole and phenanthroline derivative. Its ability to act as “naked-eye” colorimetric sensor for the detection of the drug in soft drinks and alcoholic beverages was studied. The detection process is based on the double recognition of both the hydroxyl and the carboxylate groups present in GHB, which triggers the aggregation of the AuNPs, with the resulting change in the color of the solution.https://www.mdpi.com/2227-9040/9/7/160γ-hydroxybutyric acid (GHB)gold nanoparticlescolorimetric sensing2-aminonaphthoxazolphenanthroline |
| spellingShingle | Silvia Rodríguez-Nuévalos Ana M. Costero Salvador Gil Margarita Parra Pablo Gaviña Bifunctionalized Gold Nanoparticles for the Colorimetric Detection of the Drug γ-Hydroxybutyric Acid (GHB) in Beverages Chemosensors γ-hydroxybutyric acid (GHB) gold nanoparticles colorimetric sensing 2-aminonaphthoxazol phenanthroline |
| title | Bifunctionalized Gold Nanoparticles for the Colorimetric Detection of the Drug γ-Hydroxybutyric Acid (GHB) in Beverages |
| title_full | Bifunctionalized Gold Nanoparticles for the Colorimetric Detection of the Drug γ-Hydroxybutyric Acid (GHB) in Beverages |
| title_fullStr | Bifunctionalized Gold Nanoparticles for the Colorimetric Detection of the Drug γ-Hydroxybutyric Acid (GHB) in Beverages |
| title_full_unstemmed | Bifunctionalized Gold Nanoparticles for the Colorimetric Detection of the Drug γ-Hydroxybutyric Acid (GHB) in Beverages |
| title_short | Bifunctionalized Gold Nanoparticles for the Colorimetric Detection of the Drug γ-Hydroxybutyric Acid (GHB) in Beverages |
| title_sort | bifunctionalized gold nanoparticles for the colorimetric detection of the drug γ hydroxybutyric acid ghb in beverages |
| topic | γ-hydroxybutyric acid (GHB) gold nanoparticles colorimetric sensing 2-aminonaphthoxazol phenanthroline |
| url | https://www.mdpi.com/2227-9040/9/7/160 |
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