Doing trials within trials: a qualitative study of stakeholder views on barriers and facilitators to the routine adoption of methodology research in clinical trials
Abstract Background Randomised controlled trials are the cornerstone of evidence-based health care, yet many trials struggle with recruitment and retention. All too often the methodologies employed to address these problems are not evidence-based, as rigorous methodological research on these issues...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-09-01
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| Series: | Trials |
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| Online Access: | http://link.springer.com/article/10.1186/s13063-018-2862-6 |
| _version_ | 1818058618266714112 |
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| author | Jo Rick Mike Clarke Alan A. Montgomery Paul Brocklehurst Rachel Evans Peter Bower |
| author_facet | Jo Rick Mike Clarke Alan A. Montgomery Paul Brocklehurst Rachel Evans Peter Bower |
| author_sort | Jo Rick |
| collection | DOAJ |
| description | Abstract Background Randomised controlled trials are the cornerstone of evidence-based health care, yet many trials struggle with recruitment and retention. All too often the methodologies employed to address these problems are not evidence-based, as rigorous methodological research on these issues is rare. The current research sought to identify barriers to the routine implementation of methodology research around recruitment and retention. Methods All registered UK clinical trials unit directors were sent a short questionnaire and invited to interview. Representatives of funding bodies and other stakeholders were also approached. Interviews were recorded and the content analysed. Results Data were grouped into four themes: acceptance of the need for methodological research; trial funding and development; trial processes; and organisational factors. The need to improve the evidence base for trials methodology is well established, but numerous barriers to implementation were perceived. Conclusions The knowledge and expertise required to routinely implement methodology research exists within the current research structures, and there are clear opportunities to develop the evidence base. However, for this to be achieved there is also a need for clear strategic coordination within the sector and promotion of the necessary resources. |
| first_indexed | 2024-12-10T13:03:29Z |
| format | Article |
| id | doaj.art-77543f49998c4e2eb3c74b2e0d4bdcd1 |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-12-10T13:03:29Z |
| publishDate | 2018-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-77543f49998c4e2eb3c74b2e0d4bdcd12022-12-22T01:47:55ZengBMCTrials1745-62152018-09-011911910.1186/s13063-018-2862-6Doing trials within trials: a qualitative study of stakeholder views on barriers and facilitators to the routine adoption of methodology research in clinical trialsJo Rick0Mike Clarke1Alan A. Montgomery2Paul Brocklehurst3Rachel Evans4Peter Bower5North West Hub for Trials Methodology, Manchester Academic Health Science Centre, University of ManchesterNorthern Ireland Methodology Hub, Centre for Public Health, Queens UniversityNottingham Clinical Trials Unit Faculty of Medicine and Health Sciences, Queens Medical Centre, University of NottinghamNWORTH Clinical Trials Unit, Bangor UniversityNWORTH Clinical Trials Unit, Bangor UniversityNorth West Hub for Trials Methodology, Manchester Academic Health Science Centre, University of ManchesterAbstract Background Randomised controlled trials are the cornerstone of evidence-based health care, yet many trials struggle with recruitment and retention. All too often the methodologies employed to address these problems are not evidence-based, as rigorous methodological research on these issues is rare. The current research sought to identify barriers to the routine implementation of methodology research around recruitment and retention. Methods All registered UK clinical trials unit directors were sent a short questionnaire and invited to interview. Representatives of funding bodies and other stakeholders were also approached. Interviews were recorded and the content analysed. Results Data were grouped into four themes: acceptance of the need for methodological research; trial funding and development; trial processes; and organisational factors. The need to improve the evidence base for trials methodology is well established, but numerous barriers to implementation were perceived. Conclusions The knowledge and expertise required to routinely implement methodology research exists within the current research structures, and there are clear opportunities to develop the evidence base. However, for this to be achieved there is also a need for clear strategic coordination within the sector and promotion of the necessary resources.http://link.springer.com/article/10.1186/s13063-018-2862-6RCTsSWATSMethodology research |
| spellingShingle | Jo Rick Mike Clarke Alan A. Montgomery Paul Brocklehurst Rachel Evans Peter Bower Doing trials within trials: a qualitative study of stakeholder views on barriers and facilitators to the routine adoption of methodology research in clinical trials Trials RCTs SWATS Methodology research |
| title | Doing trials within trials: a qualitative study of stakeholder views on barriers and facilitators to the routine adoption of methodology research in clinical trials |
| title_full | Doing trials within trials: a qualitative study of stakeholder views on barriers and facilitators to the routine adoption of methodology research in clinical trials |
| title_fullStr | Doing trials within trials: a qualitative study of stakeholder views on barriers and facilitators to the routine adoption of methodology research in clinical trials |
| title_full_unstemmed | Doing trials within trials: a qualitative study of stakeholder views on barriers and facilitators to the routine adoption of methodology research in clinical trials |
| title_short | Doing trials within trials: a qualitative study of stakeholder views on barriers and facilitators to the routine adoption of methodology research in clinical trials |
| title_sort | doing trials within trials a qualitative study of stakeholder views on barriers and facilitators to the routine adoption of methodology research in clinical trials |
| topic | RCTs SWATS Methodology research |
| url | http://link.springer.com/article/10.1186/s13063-018-2862-6 |
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