Caveolin-1-deficient fibroblasts promote migration, invasion, and stemness via activating the TGF-β/Smad signaling pathway in breast cancer cells

Caveolin-1-deficient fibroblasts promote migration, invasion, and stemness via activating the TGF-β/Smad signaling pathway in breast cancer cells

Cancer-associated fibroblasts (CAFs) represent one of the main components in the tumor stroma and play a key role in breast cancer progression. Transforming growth factor-β (TGF-β) has been established to mediate breast cancer metastasis by regulating the epithelial-mesenchymal transition (EMT) and...

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Bibliographic Details
Main Authors: Huang Qingyun, Wu Longyuan, Wang Yi, Kong Xinyu, Xiao Xinhua, Huang Qiyuan, Li Miao, Zhai Yujia, Shi Fuxiu, Zhao Ruichen, Zhong Junpei, Xiong Lixia
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2022-11-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
caveolin 1
cancer-associated fibroblasts
breast neoplasms
epithelial-mesenchymal transition
transforming growth factor-β
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2022150

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https://www.sciengine.com/doi/10.3724/abbs.2022150

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