Clinical efficacy and safety of glaucoma filtration surgery combined with the application of 5-fluorouracil
AIM: To observe the clinical efficacy and safety of glaucoma filtration surgery combined with the application of 5-fluorouracil for clinical treatment to offer the reference. <p>METHODS:A total of 91 cases of patients with glaucoma treated in our hospital were randomly divided into three group...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2015-01-01
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| Series: | Guoji Yanke Zazhi |
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| Online Access: | http://ies.ijo.cn/cn_publish/2015/1/201501009.pdf |
| _version_ | 1818202455885742080 |
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| author | Li-Jing Liu Bo-Wen Xiao |
| author_facet | Li-Jing Liu Bo-Wen Xiao |
| author_sort | Li-Jing Liu |
| collection | DOAJ |
| description | AIM: To observe the clinical efficacy and safety of glaucoma filtration surgery combined with the application of 5-fluorouracil for clinical treatment to offer the reference. <p>METHODS:A total of 91 cases of patients with glaucoma treated in our hospital were randomly divided into three groups, 30 cases of group A were given mitomycin in surgery, 31 cases of group B were given 5-fluorouracil, 30 cases of group C were given cyclosporine. They were given 12 -month-follow-up after operation, the operation success rate were recorded, the incidence of 1 -year-adverse reactions, visual acuity, intraocular pressure, low intraocular pressure, shallow anterior chamber, corneal damage index were recorded. <p>RESULTS: Intraocular pressure ofgroups A, B, C were respectively(20.5±8.6)mmHg,(15.2±5.5)mmHg,(20.0±8.1)mmHg,by the analysis of variance, group B was significantly lower than other two groups,<i>P</i><0.05; patients of groups A, B, C whose visual acuity increased ratios after 1y were respectively 22.5%, 38.1%,and 23.1%, by the Chi. square test, the increased ratio of group B was higher than other two groups, <i>P</i><0.05; The operation success rates after 1y of operation of groups A, B, C were respectively 67.5%,88.1%,71.8%,by the Chi square test, the increased ratio of group B was higher than other two groups, <i>P</i><0.05; The general incidence of adverse reaction were respectively 22.5%,9.5%,20.5%,by the Chi square test, the increased ratio of group B was lower than other two groups, <i>P</i><0.05. <p>CONCLUSION:Glaucoma filtration surgery combined with the application of 5-fluorouracil can improve the operation success rate, decrease the occurrence rate of adverse reaction, and safety can be improved. |
| first_indexed | 2024-12-12T03:09:44Z |
| format | Article |
| id | doaj.art-775504e1a0484a2cb5dd71cf53231855 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-12T03:09:44Z |
| publishDate | 2015-01-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-775504e1a0484a2cb5dd71cf532318552022-12-22T00:40:25ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232015-01-01151384010.3980/j.issn.1672-5123.2015.1.09Clinical efficacy and safety of glaucoma filtration surgery combined with the application of 5-fluorouracilLi-Jing Liu0Bo-Wen Xiao1Department of Ophthalmology, Tianjin Beichen Hospital, Tianjin 300400, ChinaDepartment of Ophthalmology, Tianjin Beichen Hospital, Tianjin 300400, ChinaAIM: To observe the clinical efficacy and safety of glaucoma filtration surgery combined with the application of 5-fluorouracil for clinical treatment to offer the reference. <p>METHODS:A total of 91 cases of patients with glaucoma treated in our hospital were randomly divided into three groups, 30 cases of group A were given mitomycin in surgery, 31 cases of group B were given 5-fluorouracil, 30 cases of group C were given cyclosporine. They were given 12 -month-follow-up after operation, the operation success rate were recorded, the incidence of 1 -year-adverse reactions, visual acuity, intraocular pressure, low intraocular pressure, shallow anterior chamber, corneal damage index were recorded. <p>RESULTS: Intraocular pressure ofgroups A, B, C were respectively(20.5±8.6)mmHg,(15.2±5.5)mmHg,(20.0±8.1)mmHg,by the analysis of variance, group B was significantly lower than other two groups,<i>P</i><0.05; patients of groups A, B, C whose visual acuity increased ratios after 1y were respectively 22.5%, 38.1%,and 23.1%, by the Chi. square test, the increased ratio of group B was higher than other two groups, <i>P</i><0.05; The operation success rates after 1y of operation of groups A, B, C were respectively 67.5%,88.1%,71.8%,by the Chi square test, the increased ratio of group B was higher than other two groups, <i>P</i><0.05; The general incidence of adverse reaction were respectively 22.5%,9.5%,20.5%,by the Chi square test, the increased ratio of group B was lower than other two groups, <i>P</i><0.05. <p>CONCLUSION:Glaucoma filtration surgery combined with the application of 5-fluorouracil can improve the operation success rate, decrease the occurrence rate of adverse reaction, and safety can be improved.http://ies.ijo.cn/cn_publish/2015/1/201501009.pdf5-fluorouracilglaucomafiltration surgery |
| spellingShingle | Li-Jing Liu Bo-Wen Xiao Clinical efficacy and safety of glaucoma filtration surgery combined with the application of 5-fluorouracil Guoji Yanke Zazhi 5-fluorouracil glaucoma filtration surgery |
| title | Clinical efficacy and safety of glaucoma filtration surgery combined with the application of 5-fluorouracil |
| title_full | Clinical efficacy and safety of glaucoma filtration surgery combined with the application of 5-fluorouracil |
| title_fullStr | Clinical efficacy and safety of glaucoma filtration surgery combined with the application of 5-fluorouracil |
| title_full_unstemmed | Clinical efficacy and safety of glaucoma filtration surgery combined with the application of 5-fluorouracil |
| title_short | Clinical efficacy and safety of glaucoma filtration surgery combined with the application of 5-fluorouracil |
| title_sort | clinical efficacy and safety of glaucoma filtration surgery combined with the application of 5 fluorouracil |
| topic | 5-fluorouracil glaucoma filtration surgery |
| url | http://ies.ijo.cn/cn_publish/2015/1/201501009.pdf |
| work_keys_str_mv | AT lijingliu clinicalefficacyandsafetyofglaucomafiltrationsurgerycombinedwiththeapplicationof5fluorouracil AT bowenxiao clinicalefficacyandsafetyofglaucomafiltrationsurgerycombinedwiththeapplicationof5fluorouracil |