Effectiveness of vero cell inactivated vaccine against severe acute respiratory infections (SARI) in Sibu, Malaysia: A retrospective test-negative design
The effectiveness of the vero cell inactivated vaccine (CoronaVac®) against severe acute respiratory infection (SARI) caused by SARS-CoV-2 in the real world was assessed. A matched test-negative case-control design was employed using the web-based national information system, as well as the hospit...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-01-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2023.2167438 |
| _version_ | 1797673113588072448 |
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| author | Teck-Hock Toh Yang-Yang Qi Sook-Min Yong Jeffrey Soon-Yit Lee Nur Fatin Liyana Raymond Yon-Han See Jo-Hun Teh Aw-Zien Toh Lin Naing Kamilah Dahian Jun-Wei Liew Caisha Nivenia Mose Malvina Zi-Qing Yong Ngiik-Jing Ling Diana Wang-Sing Chua Wee-Wei Ling Nanthakumar Thirunavukkarasu Mohd Raili Suhaili Jie-Lai Xia John Clemens Xuan-Yi Wang |
| author_facet | Teck-Hock Toh Yang-Yang Qi Sook-Min Yong Jeffrey Soon-Yit Lee Nur Fatin Liyana Raymond Yon-Han See Jo-Hun Teh Aw-Zien Toh Lin Naing Kamilah Dahian Jun-Wei Liew Caisha Nivenia Mose Malvina Zi-Qing Yong Ngiik-Jing Ling Diana Wang-Sing Chua Wee-Wei Ling Nanthakumar Thirunavukkarasu Mohd Raili Suhaili Jie-Lai Xia John Clemens Xuan-Yi Wang |
| author_sort | Teck-Hock Toh |
| collection | DOAJ |
| description | The effectiveness of the vero cell inactivated vaccine (CoronaVac®) against severe acute respiratory infection (SARI) caused by SARS-CoV-2 in the real world was assessed. A matched test-negative case-control design was employed using the web-based national information system, as well as the hospitalization dataset in Sibu Hospital. Vaccine effectiveness was measured by conditional logistic regression with adjustment for gender, underlying comorbidity, smoking status, and education level. Between 15 March and 30 September 2021, 838 eligible SARI patients were identified from the hospitalization records. Vaccine effectiveness was 42.4% (95% confidence interval [CI]: −28.3 to 74.1) for partial vaccination (after receiving the first dose to 14 days after receiving the second dose), and 76.5% (95% CI: 45.6 to 89.8) for complete vaccination (at 15 days or more after receiving the second dose). This analysis indicated that two doses of CoronaVac® vaccine provided efficacious protection against SARI caused by SARS-CoV-2 in the short term. However, the duration of protection, and performance against new variants need to be studied continuously. |
| first_indexed | 2024-03-11T21:39:48Z |
| format | Article |
| id | doaj.art-77574cfd0236407498f9fa2449cc4391 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T21:39:48Z |
| publishDate | 2023-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-77574cfd0236407498f9fa2449cc43912023-09-26T13:25:47ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2023-01-0119110.1080/21645515.2023.21674382167438Effectiveness of vero cell inactivated vaccine against severe acute respiratory infections (SARI) in Sibu, Malaysia: A retrospective test-negative designTeck-Hock Toh0Yang-Yang Qi1Sook-Min Yong2Jeffrey Soon-Yit Lee3Nur Fatin Liyana4Raymond Yon-Han See5Jo-Hun Teh6Aw-Zien Toh7Lin Naing8Kamilah Dahian9Jun-Wei Liew10Caisha Nivenia Mose11Malvina Zi-Qing Yong12Ngiik-Jing Ling13Diana Wang-Sing Chua14Wee-Wei Ling15Nanthakumar Thirunavukkarasu16Mohd Raili Suhaili17Jie-Lai Xia18John Clemens19Xuan-Yi Wang20Ministry of Health MalaysiaShanghai Institute of Infectious Disease and BiosecurityMinistry of Health MalaysiaMinistry of Health MalaysiaMinistry of Health MalaysiaMinistry of Health MalaysiaMinistry of Health MalaysiaMinistry of Health MalaysiaUniversity Brunei DarussalamMinistry of Health MalaysiaMinistry of Health MalaysiaMinistry of Health MalaysiaMinistry of Health MalaysiaMinistry of Health MalaysiaMinistry of Health MalaysiaMinistry of Health MalaysiaMinistry of Health MalaysiaSEGi UniversityXijing HospitalInternational Vaccine InstituteShanghai Institute of Infectious Disease and BiosecurityThe effectiveness of the vero cell inactivated vaccine (CoronaVac®) against severe acute respiratory infection (SARI) caused by SARS-CoV-2 in the real world was assessed. A matched test-negative case-control design was employed using the web-based national information system, as well as the hospitalization dataset in Sibu Hospital. Vaccine effectiveness was measured by conditional logistic regression with adjustment for gender, underlying comorbidity, smoking status, and education level. Between 15 March and 30 September 2021, 838 eligible SARI patients were identified from the hospitalization records. Vaccine effectiveness was 42.4% (95% confidence interval [CI]: −28.3 to 74.1) for partial vaccination (after receiving the first dose to 14 days after receiving the second dose), and 76.5% (95% CI: 45.6 to 89.8) for complete vaccination (at 15 days or more after receiving the second dose). This analysis indicated that two doses of CoronaVac® vaccine provided efficacious protection against SARI caused by SARS-CoV-2 in the short term. However, the duration of protection, and performance against new variants need to be studied continuously.http://dx.doi.org/10.1080/21645515.2023.2167438effectivenessinactivated vaccinesevere acute respiratory infectionstest-negative designcovid-19 |
| spellingShingle | Teck-Hock Toh Yang-Yang Qi Sook-Min Yong Jeffrey Soon-Yit Lee Nur Fatin Liyana Raymond Yon-Han See Jo-Hun Teh Aw-Zien Toh Lin Naing Kamilah Dahian Jun-Wei Liew Caisha Nivenia Mose Malvina Zi-Qing Yong Ngiik-Jing Ling Diana Wang-Sing Chua Wee-Wei Ling Nanthakumar Thirunavukkarasu Mohd Raili Suhaili Jie-Lai Xia John Clemens Xuan-Yi Wang Effectiveness of vero cell inactivated vaccine against severe acute respiratory infections (SARI) in Sibu, Malaysia: A retrospective test-negative design Human Vaccines & Immunotherapeutics effectiveness inactivated vaccine severe acute respiratory infections test-negative design covid-19 |
| title | Effectiveness of vero cell inactivated vaccine against severe acute respiratory infections (SARI) in Sibu, Malaysia: A retrospective test-negative design |
| title_full | Effectiveness of vero cell inactivated vaccine against severe acute respiratory infections (SARI) in Sibu, Malaysia: A retrospective test-negative design |
| title_fullStr | Effectiveness of vero cell inactivated vaccine against severe acute respiratory infections (SARI) in Sibu, Malaysia: A retrospective test-negative design |
| title_full_unstemmed | Effectiveness of vero cell inactivated vaccine against severe acute respiratory infections (SARI) in Sibu, Malaysia: A retrospective test-negative design |
| title_short | Effectiveness of vero cell inactivated vaccine against severe acute respiratory infections (SARI) in Sibu, Malaysia: A retrospective test-negative design |
| title_sort | effectiveness of vero cell inactivated vaccine against severe acute respiratory infections sari in sibu malaysia a retrospective test negative design |
| topic | effectiveness inactivated vaccine severe acute respiratory infections test-negative design covid-19 |
| url | http://dx.doi.org/10.1080/21645515.2023.2167438 |
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