MLKL deficiency in Braf V600E Pten −/− melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice

MLKL deficiency in Braf V600E Pten −/− melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice

Abstract Cancers acquire several capabilities to survive the multistep process in carcinogenesis. Resisting cell death is one of them. Silencing of the necroptosis initiator Ripk3 occurs in a wide variety of cancer types including melanoma. Little is known about the role of the necroptosis execution...

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Bibliographic Details
Main Authors: Sofie Martens, Nozomi Takahashi, Gillian Blancke, Niels Vandamme, Hanne Verschuere, Tatyana Divert, Marnik Vuylsteke, Geert Berx, Peter Vandenabeele
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04819-4

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