Regulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece?
Mitochondria, as “power house of the cell”, are crucial players in cell pathophysiology. Beyond adenosine triphosphate (ATP) production, they take part in a generation of reactive oxygen species (ROS), regulation of cell signaling and cell death. Dysregulation of mitochondrial dynamics may lead to c...
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MDPI AG
2021-02-01
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Series: | Antioxidants |
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Online Access: | https://www.mdpi.com/2076-3921/10/2/248 |
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author | Paulina Bastian Jaroslaw Dulski Anna Roszmann Dagmara Jacewicz Alicja Kuban-Jankowska Jaroslaw Slawek Michal Wozniak Magdalena Gorska-Ponikowska |
author_facet | Paulina Bastian Jaroslaw Dulski Anna Roszmann Dagmara Jacewicz Alicja Kuban-Jankowska Jaroslaw Slawek Michal Wozniak Magdalena Gorska-Ponikowska |
author_sort | Paulina Bastian |
collection | DOAJ |
description | Mitochondria, as “power house of the cell”, are crucial players in cell pathophysiology. Beyond adenosine triphosphate (ATP) production, they take part in a generation of reactive oxygen species (ROS), regulation of cell signaling and cell death. Dysregulation of mitochondrial dynamics may lead to cancers and neurodegeneration; however, the fusion/fission cycle allows mitochondria to adapt to metabolic needs of the cell. There are multiple data suggesting that disturbed mitochondrial homeostasis can lead to Parkinson’s disease (PD) development. 2-methoxyestradiol (2-ME), metabolite of 17β-estradiol (E2) and potential anticancer agent, was demonstrated to inhibit cell growth of hippocampal HT22 cells by means of nitric oxide synthase (NOS) production and oxidative stress at both pharmacologically and also physiologically relevant concentrations. Moreover, 2-ME was suggested to inhibit mitochondrial biogenesis and to be a dynamic regulator. This review is a comprehensive discussion, from both scientific and clinical point of view, about the influence of 2-ME on mitochondria and its plausible role as a modulator of neuron survival. |
first_indexed | 2024-03-09T05:22:14Z |
format | Article |
id | doaj.art-7758c4ddc86a4292903c75390bf1a258 |
institution | Directory Open Access Journal |
issn | 2076-3921 |
language | English |
last_indexed | 2024-03-09T05:22:14Z |
publishDate | 2021-02-01 |
publisher | MDPI AG |
record_format | Article |
series | Antioxidants |
spelling | doaj.art-7758c4ddc86a4292903c75390bf1a2582023-12-03T12:39:35ZengMDPI AGAntioxidants2076-39212021-02-0110224810.3390/antiox10020248Regulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece?Paulina Bastian0Jaroslaw Dulski1Anna Roszmann2Dagmara Jacewicz3Alicja Kuban-Jankowska4Jaroslaw Slawek5Michal Wozniak6Magdalena Gorska-Ponikowska7Department of Medical Chemistry, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, PolandDepartment of Neurological-Psychiatric Nursing, Medical University of Gdansk, 80-211 Gdansk, PolandDepartment of Neurological-Psychiatric Nursing, Medical University of Gdansk, 80-211 Gdansk, PolandFaculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, PolandDepartment of Medical Chemistry, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, PolandDepartment of Neurological-Psychiatric Nursing, Medical University of Gdansk, 80-211 Gdansk, PolandDepartment of Medical Chemistry, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, PolandDepartment of Medical Chemistry, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, PolandMitochondria, as “power house of the cell”, are crucial players in cell pathophysiology. Beyond adenosine triphosphate (ATP) production, they take part in a generation of reactive oxygen species (ROS), regulation of cell signaling and cell death. Dysregulation of mitochondrial dynamics may lead to cancers and neurodegeneration; however, the fusion/fission cycle allows mitochondria to adapt to metabolic needs of the cell. There are multiple data suggesting that disturbed mitochondrial homeostasis can lead to Parkinson’s disease (PD) development. 2-methoxyestradiol (2-ME), metabolite of 17β-estradiol (E2) and potential anticancer agent, was demonstrated to inhibit cell growth of hippocampal HT22 cells by means of nitric oxide synthase (NOS) production and oxidative stress at both pharmacologically and also physiologically relevant concentrations. Moreover, 2-ME was suggested to inhibit mitochondrial biogenesis and to be a dynamic regulator. This review is a comprehensive discussion, from both scientific and clinical point of view, about the influence of 2-ME on mitochondria and its plausible role as a modulator of neuron survival.https://www.mdpi.com/2076-3921/10/2/2482-methoxyestradioloxidative stressnitric oxideParkinson’s diseasemitochondriacancer |
spellingShingle | Paulina Bastian Jaroslaw Dulski Anna Roszmann Dagmara Jacewicz Alicja Kuban-Jankowska Jaroslaw Slawek Michal Wozniak Magdalena Gorska-Ponikowska Regulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece? Antioxidants 2-methoxyestradiol oxidative stress nitric oxide Parkinson’s disease mitochondria cancer |
title | Regulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece? |
title_full | Regulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece? |
title_fullStr | Regulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece? |
title_full_unstemmed | Regulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece? |
title_short | Regulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece? |
title_sort | regulation of mitochondrial dynamics in parkinson s disease is 2 methoxyestradiol a missing piece |
topic | 2-methoxyestradiol oxidative stress nitric oxide Parkinson’s disease mitochondria cancer |
url | https://www.mdpi.com/2076-3921/10/2/248 |
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