HYPERANDROGENISM OF PUBERTY AGE AS A FACTOR REDUCING FERTILITY
Aim. Hyperandrogenism is a common cause of infertility in women. The onset of symptoms of hyperandrogenism takes place during puberty in the majority of women. Hyperandrogenism reduces reproductive potential,so early detection and development of its prognostic factors, allows us to solve serious pro...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Siberian State Medical University (Tomsk)
2016-03-01
|
| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/482 |
| _version_ | 1797872901176688640 |
|---|---|
| author | E. M. Bogatyreva G. A. Novik G. F. Kutusheva |
| author_facet | E. M. Bogatyreva G. A. Novik G. F. Kutusheva |
| author_sort | E. M. Bogatyreva |
| collection | DOAJ |
| description | Aim. Hyperandrogenism is a common cause of infertility in women. The onset of symptoms of hyperandrogenism takes place during puberty in the majority of women. Hyperandrogenism reduces reproductive potential,so early detection and development of its prognostic factors, allows us to solve serious problems of puberty and prevent infertility.Materials and methods. 113 adolescent girls with hyperandrogenism from 14 to 19 years were included. The control group consists of 25 healthy girls of a similar age. To confirm the prediction of decreased reproductive capacity were examined 35 women with hyperandrogenism from 19 to 36 years. In addition to routine methods of examination (anamnesis, physical examination, anthropometry, assessment of the hairline using Ferriman – Gallwey scale, ultrasound of the pelvic organs, the definition of the hormonal status (LH, FSH, prolactin, 17-OHP, estradiol, TSH, DHEAS-s, GHPG, testosterone), glucose, insulin, glucose tolerance test and dexamethasone suppression test when necessary.Results. We have proved the reduction of reproductive potential of adolescent girls with high free androgen index (FAI). When the FAI has increased from 36 to 100 conventional units it caused reduction of the reproductive capacity in 9.7 times in comparison with control group (χ2=56,24; p < 0.001; overall prediction accuracy of 92.8%).Conclusion. Free androgen index more than 36 conventional units is a high risk factor of reduced fertility. |
| first_indexed | 2024-04-10T01:07:34Z |
| format | Article |
| id | doaj.art-775935d5ed8f41aabe80de13907d94fb |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:07:34Z |
| publishDate | 2016-03-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-775935d5ed8f41aabe80de13907d94fb2023-03-13T09:58:22ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842016-03-01151142110.20538/1682-0363-2016-1-14-21455HYPERANDROGENISM OF PUBERTY AGE AS A FACTOR REDUCING FERTILITYE. M. Bogatyreva0G. A. Novik1G. F. Kutusheva2Санкт-Петербургский государственный педиатрический медицинский университет, г. Санкт-Петербург, ул. Литовская, 2Санкт-Петербургский государственный педиатрический медицинский университет, г. Санкт-Петербург, ул. Литовская, 2Санкт-Петербургский государственный педиатрический медицинский университет, г. Санкт-Петербург, ул. Литовская, 2Aim. Hyperandrogenism is a common cause of infertility in women. The onset of symptoms of hyperandrogenism takes place during puberty in the majority of women. Hyperandrogenism reduces reproductive potential,so early detection and development of its prognostic factors, allows us to solve serious problems of puberty and prevent infertility.Materials and methods. 113 adolescent girls with hyperandrogenism from 14 to 19 years were included. The control group consists of 25 healthy girls of a similar age. To confirm the prediction of decreased reproductive capacity were examined 35 women with hyperandrogenism from 19 to 36 years. In addition to routine methods of examination (anamnesis, physical examination, anthropometry, assessment of the hairline using Ferriman – Gallwey scale, ultrasound of the pelvic organs, the definition of the hormonal status (LH, FSH, prolactin, 17-OHP, estradiol, TSH, DHEAS-s, GHPG, testosterone), glucose, insulin, glucose tolerance test and dexamethasone suppression test when necessary.Results. We have proved the reduction of reproductive potential of adolescent girls with high free androgen index (FAI). When the FAI has increased from 36 to 100 conventional units it caused reduction of the reproductive capacity in 9.7 times in comparison with control group (χ2=56,24; p < 0.001; overall prediction accuracy of 92.8%).Conclusion. Free androgen index more than 36 conventional units is a high risk factor of reduced fertility.https://bulletin.ssmu.ru/jour/article/view/482гиперандрогениядевочки-подросткисиндром поликистозных яичниковрепродуктивный потенциалснижение фертильностипрогнозирование |
| spellingShingle | E. M. Bogatyreva G. A. Novik G. F. Kutusheva HYPERANDROGENISM OF PUBERTY AGE AS A FACTOR REDUCING FERTILITY Бюллетень сибирской медицины гиперандрогения девочки-подростки синдром поликистозных яичников репродуктивный потенциал снижение фертильности прогнозирование |
| title | HYPERANDROGENISM OF PUBERTY AGE AS A FACTOR REDUCING FERTILITY |
| title_full | HYPERANDROGENISM OF PUBERTY AGE AS A FACTOR REDUCING FERTILITY |
| title_fullStr | HYPERANDROGENISM OF PUBERTY AGE AS A FACTOR REDUCING FERTILITY |
| title_full_unstemmed | HYPERANDROGENISM OF PUBERTY AGE AS A FACTOR REDUCING FERTILITY |
| title_short | HYPERANDROGENISM OF PUBERTY AGE AS A FACTOR REDUCING FERTILITY |
| title_sort | hyperandrogenism of puberty age as a factor reducing fertility |
| topic | гиперандрогения девочки-подростки синдром поликистозных яичников репродуктивный потенциал снижение фертильности прогнозирование |
| url | https://bulletin.ssmu.ru/jour/article/view/482 |
| work_keys_str_mv | AT embogatyreva hyperandrogenismofpubertyageasafactorreducingfertility AT ganovik hyperandrogenismofpubertyageasafactorreducingfertility AT gfkutusheva hyperandrogenismofpubertyageasafactorreducingfertility |