In vitro activity of cefiderocol against Gram-negative pathogens isolated from people with cystic fibrosis and bronchiectasis
ABSTRACT: Objectives: Gram-negative pathogens causing respiratory infection in people with cystic fibrosis and bronchiectasis are becoming progressively more resistant to conventional antibiotics. Although cefiderocol is licenced for the treatment of infections due to Gram-negative organisms, there...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Journal of Global Antimicrobial Resistance |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716524000298 |
| _version_ | 1797249151621136384 |
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| author | Michael M Tunney J Stuart Elborn Chloe S McLaughlin Christopher M Longshaw |
| author_facet | Michael M Tunney J Stuart Elborn Chloe S McLaughlin Christopher M Longshaw |
| author_sort | Michael M Tunney |
| collection | DOAJ |
| description | ABSTRACT: Objectives: Gram-negative pathogens causing respiratory infection in people with cystic fibrosis and bronchiectasis are becoming progressively more resistant to conventional antibiotics. Although cefiderocol is licenced for the treatment of infections due to Gram-negative organisms, there are limited data on the activity of cefiderocol against pathogens associated with chronic respiratory diseases. The aim of this study was to determine the susceptibility of Gram-negative pathogens from cystic fibrosis and bronchiectasis to cefiderocol and comparator antibiotics. Methods: Minimal inhibitory concentrations (MICs) of cefiderocol and 15 comparator antibiotics were determined by broth microdilution against 300 respiratory isolates: Burkholderia spp., Stenotrophomonas spp., Achromobacter spp., Ralstonia spp. and Pandoraea spp., and used to calculate the MIC of each antibiotic required to inhibit 50% (MIC50) and 90% (MIC90) of isolates. Results: The MIC50 and MIC90 of cefiderocol for all 300 isolates tested was 0.25 and 32 mg/L, with 232 (77.3%) isolates having an MIC value ≤2 mg/L. In addition, cefiderocol demonstrated excellent activity against Stenotrophomonas spp. and Achromobacter spp. isolates, with 86.7% and 87.2%, respectively, exhibiting an MIC of 2 mg/L. Tigecycline also demonstrated good activity against all isolates with an MIC50 of <0.5 mg/L. Conclusions: These in vitro data demonstrated that cefiderocol had greater activity than most comparator antibiotics and could be an alternative treatment option for respiratory infection caused by these pathogens that has not responded to first-line therapy. |
| first_indexed | 2024-04-24T20:25:56Z |
| format | Article |
| id | doaj.art-775938bb17934ee3ab5b0511bb71c32e |
| institution | Directory Open Access Journal |
| issn | 2213-7165 |
| language | English |
| last_indexed | 2024-04-24T20:25:56Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj.art-775938bb17934ee3ab5b0511bb71c32e2024-03-22T05:39:35ZengElsevierJournal of Global Antimicrobial Resistance2213-71652024-03-0136407410In vitro activity of cefiderocol against Gram-negative pathogens isolated from people with cystic fibrosis and bronchiectasisMichael M Tunney0J Stuart Elborn1Chloe S McLaughlin2Christopher M Longshaw3School of Pharmacy, Queen's University Belfast, Belfast, UK; Corresponding author. Mailing address: School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, Northern Ireland.Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UKSchool of Pharmacy, Queen's University Belfast, Belfast, UKEU Scientific Affairs, Shionogi B.V., London, UKABSTRACT: Objectives: Gram-negative pathogens causing respiratory infection in people with cystic fibrosis and bronchiectasis are becoming progressively more resistant to conventional antibiotics. Although cefiderocol is licenced for the treatment of infections due to Gram-negative organisms, there are limited data on the activity of cefiderocol against pathogens associated with chronic respiratory diseases. The aim of this study was to determine the susceptibility of Gram-negative pathogens from cystic fibrosis and bronchiectasis to cefiderocol and comparator antibiotics. Methods: Minimal inhibitory concentrations (MICs) of cefiderocol and 15 comparator antibiotics were determined by broth microdilution against 300 respiratory isolates: Burkholderia spp., Stenotrophomonas spp., Achromobacter spp., Ralstonia spp. and Pandoraea spp., and used to calculate the MIC of each antibiotic required to inhibit 50% (MIC50) and 90% (MIC90) of isolates. Results: The MIC50 and MIC90 of cefiderocol for all 300 isolates tested was 0.25 and 32 mg/L, with 232 (77.3%) isolates having an MIC value ≤2 mg/L. In addition, cefiderocol demonstrated excellent activity against Stenotrophomonas spp. and Achromobacter spp. isolates, with 86.7% and 87.2%, respectively, exhibiting an MIC of 2 mg/L. Tigecycline also demonstrated good activity against all isolates with an MIC50 of <0.5 mg/L. Conclusions: These in vitro data demonstrated that cefiderocol had greater activity than most comparator antibiotics and could be an alternative treatment option for respiratory infection caused by these pathogens that has not responded to first-line therapy.http://www.sciencedirect.com/science/article/pii/S2213716524000298CefiderocolCystic fibrosisStenotrophomonas maltophiliaAchromobacterBurkholderia cepacia complex |
| spellingShingle | Michael M Tunney J Stuart Elborn Chloe S McLaughlin Christopher M Longshaw In vitro activity of cefiderocol against Gram-negative pathogens isolated from people with cystic fibrosis and bronchiectasis Journal of Global Antimicrobial Resistance Cefiderocol Cystic fibrosis Stenotrophomonas maltophilia Achromobacter Burkholderia cepacia complex |
| title | In vitro activity of cefiderocol against Gram-negative pathogens isolated from people with cystic fibrosis and bronchiectasis |
| title_full | In vitro activity of cefiderocol against Gram-negative pathogens isolated from people with cystic fibrosis and bronchiectasis |
| title_fullStr | In vitro activity of cefiderocol against Gram-negative pathogens isolated from people with cystic fibrosis and bronchiectasis |
| title_full_unstemmed | In vitro activity of cefiderocol against Gram-negative pathogens isolated from people with cystic fibrosis and bronchiectasis |
| title_short | In vitro activity of cefiderocol against Gram-negative pathogens isolated from people with cystic fibrosis and bronchiectasis |
| title_sort | in vitro activity of cefiderocol against gram negative pathogens isolated from people with cystic fibrosis and bronchiectasis |
| topic | Cefiderocol Cystic fibrosis Stenotrophomonas maltophilia Achromobacter Burkholderia cepacia complex |
| url | http://www.sciencedirect.com/science/article/pii/S2213716524000298 |
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