High-Sensitivity Detection of IgG Operating near the Dispersion Turning Point in Tapered Two-Mode Fibers
The conventional methods for monitoring IgG levels suffer from some apparent problems such as long assay time, multistep processing, and high overall cost. An effective and suitable optical platform for label-free biosensing was investigated by the implementation of antibody/antigen immunoassays. Th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/11/3/270 |
| _version_ | 1818282499137077248 |
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| author | Bing Sun Yiping Wang |
| author_facet | Bing Sun Yiping Wang |
| author_sort | Bing Sun |
| collection | DOAJ |
| description | The conventional methods for monitoring IgG levels suffer from some apparent problems such as long assay time, multistep processing, and high overall cost. An effective and suitable optical platform for label-free biosensing was investigated by the implementation of antibody/antigen immunoassays. The ultrasensitive detection of IgG levels could be achieved by exploiting the dispersion turning point (DTP) existing in the tapered two-mode fibers (TTMFs) because the sensitivity will reach ±∞ on either side of the DTP. Tracking the resonant wavelength shift, it was found that the fabricated TTMF device exhibited limits of detection (LOD) down to concentrations of 10 fg/mL of IgG in PBS solution. Such immunosensors based on DTP have great significance on trace detection of IgG due to simple detection scheme, quick response time, and miniaturization. |
| first_indexed | 2024-12-13T00:21:59Z |
| format | Article |
| id | doaj.art-775ce4e7fd3049249326a5f1007f1817 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-12-13T00:21:59Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-775ce4e7fd3049249326a5f1007f18172022-12-22T00:05:33ZengMDPI AGMicromachines2072-666X2020-03-0111327010.3390/mi11030270mi11030270High-Sensitivity Detection of IgG Operating near the Dispersion Turning Point in Tapered Two-Mode FibersBing Sun0Yiping Wang1Guangdong and Hong Kong Joint Research Centre for Optical Fibre Sensors, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, ChinaGuangdong and Hong Kong Joint Research Centre for Optical Fibre Sensors, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, ChinaThe conventional methods for monitoring IgG levels suffer from some apparent problems such as long assay time, multistep processing, and high overall cost. An effective and suitable optical platform for label-free biosensing was investigated by the implementation of antibody/antigen immunoassays. The ultrasensitive detection of IgG levels could be achieved by exploiting the dispersion turning point (DTP) existing in the tapered two-mode fibers (TTMFs) because the sensitivity will reach ±∞ on either side of the DTP. Tracking the resonant wavelength shift, it was found that the fabricated TTMF device exhibited limits of detection (LOD) down to concentrations of 10 fg/mL of IgG in PBS solution. Such immunosensors based on DTP have great significance on trace detection of IgG due to simple detection scheme, quick response time, and miniaturization.https://www.mdpi.com/2072-666X/11/3/270biosensoroptical fiber sensortwo-mode fibersensitivity |
| spellingShingle | Bing Sun Yiping Wang High-Sensitivity Detection of IgG Operating near the Dispersion Turning Point in Tapered Two-Mode Fibers Micromachines biosensor optical fiber sensor two-mode fiber sensitivity |
| title | High-Sensitivity Detection of IgG Operating near the Dispersion Turning Point in Tapered Two-Mode Fibers |
| title_full | High-Sensitivity Detection of IgG Operating near the Dispersion Turning Point in Tapered Two-Mode Fibers |
| title_fullStr | High-Sensitivity Detection of IgG Operating near the Dispersion Turning Point in Tapered Two-Mode Fibers |
| title_full_unstemmed | High-Sensitivity Detection of IgG Operating near the Dispersion Turning Point in Tapered Two-Mode Fibers |
| title_short | High-Sensitivity Detection of IgG Operating near the Dispersion Turning Point in Tapered Two-Mode Fibers |
| title_sort | high sensitivity detection of igg operating near the dispersion turning point in tapered two mode fibers |
| topic | biosensor optical fiber sensor two-mode fiber sensitivity |
| url | https://www.mdpi.com/2072-666X/11/3/270 |
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