Insights from the COCOA birth cohort: The origins of childhood allergic diseases and future perspectives
The ongoing COhort for Childhood Origin of Asthma and allergic diseases (COCOA) study is a prospective birth cohort investigating the origin and natural courses of childhood allergic diseases, including atopic dermatitis, food allergy, allergic rhinitis and asthma, with long-term prognosis. Initiate...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S132389302300103X |
| _version_ | 1797365584690675712 |
|---|---|
| author | Eun Lee So-Yeon Lee Hyo-Bin Kim Song-I Yang Jisun Yoon Dong In Suh Hea Young Oh Kangmo Ahn Kyung Won Kim Youn Ho Shin Soo-Jong Hong |
| author_facet | Eun Lee So-Yeon Lee Hyo-Bin Kim Song-I Yang Jisun Yoon Dong In Suh Hea Young Oh Kangmo Ahn Kyung Won Kim Youn Ho Shin Soo-Jong Hong |
| author_sort | Eun Lee |
| collection | DOAJ |
| description | The ongoing COhort for Childhood Origin of Asthma and allergic diseases (COCOA) study is a prospective birth cohort investigating the origin and natural courses of childhood allergic diseases, including atopic dermatitis, food allergy, allergic rhinitis and asthma, with long-term prognosis. Initiated under the premise that allergic diseases result from a complex interplay of immune development alterations, environmental exposures, and host susceptibility, the COCOA study explores these dynamic interactions during prenatal and postnatal periods, framed within the hygiene and microbial hypotheses alongside the developmental origins of health and disease (DOHaD) hypothesis. The scope of the COCOA study extends to genetic predispositions, indoor and outdoor environmental variables affecting mothers and their offsprings such as outdoor and indoor air pollution, psychological factors, diets, and the microbiomes of skin, gut, and airway. We have embarked on in-depth investigations of diverse risk factors and the pathophysiological underpinnings of allergic diseases. By employing multi-omics approaches—proteomics, transcriptomics, and metabolomics—we gain deeper insights into the distinct pathophysiological processes across various endotypes of childhood allergic diseases, incorporating the exposome using extensive resources within the COCOA study. Integration with large-scale datasets, such as national health insurance records, enhances robustness and mitigates potential limitations inherent to birth cohort studies. As part of global networks focused on childhood allergic diseases, the COCOA study fosters collaborative research across multiple cohorts. The findings from the COCOA study are instrumental in informing precision medicine strategies for childhood allergic diseases, underpinning the establishment of disease trajectories. |
| first_indexed | 2024-03-08T16:52:01Z |
| format | Article |
| id | doaj.art-775cfec92679481d8bc1bdd40c71cb66 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-03-08T16:52:01Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-775cfec92679481d8bc1bdd40c71cb662024-01-05T04:23:49ZengElsevierAllergology International1323-89302024-01-01731312Insights from the COCOA birth cohort: The origins of childhood allergic diseases and future perspectivesEun Lee0So-Yeon Lee1Hyo-Bin Kim2Song-I Yang3Jisun Yoon4Dong In Suh5Hea Young Oh6Kangmo Ahn7Kyung Won Kim8Youn Ho Shin9Soo-Jong Hong10Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South KoreaDepartment of Pediatrics, Childhood Asthma Atopy Center, Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaDepartment of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, South KoreaDepartment of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South KoreaDepartment of Pediatrics, Chung-Ang University College of Medicine, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, South KoreaDepartment of Pediatrics, Seoul National University College of Medicine, Seoul, South KoreaDepartment of Medicine, University of Ulsan College of Medicine, Seoul, South KoreaDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDepartment of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Pediatrics, The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul, South KoreaDepartment of Pediatrics, Childhood Asthma Atopy Center, Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea; Corresponding author. Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, 88 Olympic-Ro 43-Gil, Songpa-Gu, Seoul 05505, South Korea.The ongoing COhort for Childhood Origin of Asthma and allergic diseases (COCOA) study is a prospective birth cohort investigating the origin and natural courses of childhood allergic diseases, including atopic dermatitis, food allergy, allergic rhinitis and asthma, with long-term prognosis. Initiated under the premise that allergic diseases result from a complex interplay of immune development alterations, environmental exposures, and host susceptibility, the COCOA study explores these dynamic interactions during prenatal and postnatal periods, framed within the hygiene and microbial hypotheses alongside the developmental origins of health and disease (DOHaD) hypothesis. The scope of the COCOA study extends to genetic predispositions, indoor and outdoor environmental variables affecting mothers and their offsprings such as outdoor and indoor air pollution, psychological factors, diets, and the microbiomes of skin, gut, and airway. We have embarked on in-depth investigations of diverse risk factors and the pathophysiological underpinnings of allergic diseases. By employing multi-omics approaches—proteomics, transcriptomics, and metabolomics—we gain deeper insights into the distinct pathophysiological processes across various endotypes of childhood allergic diseases, incorporating the exposome using extensive resources within the COCOA study. Integration with large-scale datasets, such as national health insurance records, enhances robustness and mitigates potential limitations inherent to birth cohort studies. As part of global networks focused on childhood allergic diseases, the COCOA study fosters collaborative research across multiple cohorts. The findings from the COCOA study are instrumental in informing precision medicine strategies for childhood allergic diseases, underpinning the establishment of disease trajectories.http://www.sciencedirect.com/science/article/pii/S132389302300103XAllergic diseaseCohortEndotypeExposomeOmics |
| spellingShingle | Eun Lee So-Yeon Lee Hyo-Bin Kim Song-I Yang Jisun Yoon Dong In Suh Hea Young Oh Kangmo Ahn Kyung Won Kim Youn Ho Shin Soo-Jong Hong Insights from the COCOA birth cohort: The origins of childhood allergic diseases and future perspectives Allergology International Allergic disease Cohort Endotype Exposome Omics |
| title | Insights from the COCOA birth cohort: The origins of childhood allergic diseases and future perspectives |
| title_full | Insights from the COCOA birth cohort: The origins of childhood allergic diseases and future perspectives |
| title_fullStr | Insights from the COCOA birth cohort: The origins of childhood allergic diseases and future perspectives |
| title_full_unstemmed | Insights from the COCOA birth cohort: The origins of childhood allergic diseases and future perspectives |
| title_short | Insights from the COCOA birth cohort: The origins of childhood allergic diseases and future perspectives |
| title_sort | insights from the cocoa birth cohort the origins of childhood allergic diseases and future perspectives |
| topic | Allergic disease Cohort Endotype Exposome Omics |
| url | http://www.sciencedirect.com/science/article/pii/S132389302300103X |
| work_keys_str_mv | AT eunlee insightsfromthecocoabirthcohorttheoriginsofchildhoodallergicdiseasesandfutureperspectives AT soyeonlee insightsfromthecocoabirthcohorttheoriginsofchildhoodallergicdiseasesandfutureperspectives AT hyobinkim insightsfromthecocoabirthcohorttheoriginsofchildhoodallergicdiseasesandfutureperspectives AT songiyang insightsfromthecocoabirthcohorttheoriginsofchildhoodallergicdiseasesandfutureperspectives AT jisunyoon insightsfromthecocoabirthcohorttheoriginsofchildhoodallergicdiseasesandfutureperspectives AT donginsuh insightsfromthecocoabirthcohorttheoriginsofchildhoodallergicdiseasesandfutureperspectives AT heayoungoh insightsfromthecocoabirthcohorttheoriginsofchildhoodallergicdiseasesandfutureperspectives AT kangmoahn insightsfromthecocoabirthcohorttheoriginsofchildhoodallergicdiseasesandfutureperspectives AT kyungwonkim insightsfromthecocoabirthcohorttheoriginsofchildhoodallergicdiseasesandfutureperspectives AT younhoshin insightsfromthecocoabirthcohorttheoriginsofchildhoodallergicdiseasesandfutureperspectives AT soojonghong insightsfromthecocoabirthcohorttheoriginsofchildhoodallergicdiseasesandfutureperspectives |