The Effects of Ellagic Acid on Experimental Corrosive Esophageal Burn Injury
This study aimed to investigate the antioxidant effect of Ellagic acid (EA) on wound healing in sodium hydroxide (NaOH)-induced corrosive esophageal burn injury. The interaction networks and functional annotations were conducted using Cytoscape software. A total of 24 Wistar albino rats were divided...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/46/2/102 |
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| author | Dilek Aygün Keşim Fırat Aşır Hayat Ayaz Tuğcan Korak |
| author_facet | Dilek Aygün Keşim Fırat Aşır Hayat Ayaz Tuğcan Korak |
| author_sort | Dilek Aygün Keşim |
| collection | DOAJ |
| description | This study aimed to investigate the antioxidant effect of Ellagic acid (EA) on wound healing in sodium hydroxide (NaOH)-induced corrosive esophageal burn injury. The interaction networks and functional annotations were conducted using Cytoscape software. A total of 24 Wistar albino rats were divided into control, corrosive esophageal burn (CEB) and CEB + EA groups. Burn injury was created by 20% NaOH and 30 mg/kg EA was per oral administered to rats. At the end of the 28-day experimental period, Malondialdehyde (MDA) content was measured. Esophageal tissue samples were processed for histological staining. The EA–target interaction network was revealed to be involved in regulating crucial cellular mechanisms for burn wound healing, with epidermal growth factor (EGF) identified as a central mediator. An increase in animal weight in the CEB + EA group was observed in the EA-treated group after CEB injury. Burn injury increased MDA content, but EA treatment decreased its level after CEB injury. Stenosis index, collagen degeneration, inflammation, fibrosis and necrosis levels were increased after CEB injury. EA treatment improved histopathology in the CEB + EA group compared to the CEB group. The expression of EGF was decreased in the CEB group but upregulated in the EA-treated group, suggesting a potential involvement of EA in cellular processes and tissue regeneration. EA, through its antioxidative and tissue regenerative properties, significantly contributes to alleviating the adverse effects of CEB injury, promoting wound healing. |
| first_indexed | 2024-03-07T22:37:41Z |
| format | Article |
| id | doaj.art-775ea154a9bc4e4495e80a6150de16c0 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-07T22:37:41Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-775ea154a9bc4e4495e80a6150de16c02024-02-23T15:12:40ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452024-02-014621579159210.3390/cimb46020102The Effects of Ellagic Acid on Experimental Corrosive Esophageal Burn InjuryDilek Aygün Keşim0Fırat Aşır1Hayat Ayaz2Tuğcan Korak3Department of Physiology, Medical Faculty, Dicle University, Diyarbakır 21280, TurkeyDepartment of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır 21280, TurkeyDepartment of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır 21280, TurkeyDepartment of Medical Biology, Medical Faculty, Kocaeli University, Kocaeli 41001, TurkeyThis study aimed to investigate the antioxidant effect of Ellagic acid (EA) on wound healing in sodium hydroxide (NaOH)-induced corrosive esophageal burn injury. The interaction networks and functional annotations were conducted using Cytoscape software. A total of 24 Wistar albino rats were divided into control, corrosive esophageal burn (CEB) and CEB + EA groups. Burn injury was created by 20% NaOH and 30 mg/kg EA was per oral administered to rats. At the end of the 28-day experimental period, Malondialdehyde (MDA) content was measured. Esophageal tissue samples were processed for histological staining. The EA–target interaction network was revealed to be involved in regulating crucial cellular mechanisms for burn wound healing, with epidermal growth factor (EGF) identified as a central mediator. An increase in animal weight in the CEB + EA group was observed in the EA-treated group after CEB injury. Burn injury increased MDA content, but EA treatment decreased its level after CEB injury. Stenosis index, collagen degeneration, inflammation, fibrosis and necrosis levels were increased after CEB injury. EA treatment improved histopathology in the CEB + EA group compared to the CEB group. The expression of EGF was decreased in the CEB group but upregulated in the EA-treated group, suggesting a potential involvement of EA in cellular processes and tissue regeneration. EA, through its antioxidative and tissue regenerative properties, significantly contributes to alleviating the adverse effects of CEB injury, promoting wound healing.https://www.mdpi.com/1467-3045/46/2/102ellagic acidantioxidantanti-inflammatorycorrosive substanceNaOH |
| spellingShingle | Dilek Aygün Keşim Fırat Aşır Hayat Ayaz Tuğcan Korak The Effects of Ellagic Acid on Experimental Corrosive Esophageal Burn Injury Current Issues in Molecular Biology ellagic acid antioxidant anti-inflammatory corrosive substance NaOH |
| title | The Effects of Ellagic Acid on Experimental Corrosive Esophageal Burn Injury |
| title_full | The Effects of Ellagic Acid on Experimental Corrosive Esophageal Burn Injury |
| title_fullStr | The Effects of Ellagic Acid on Experimental Corrosive Esophageal Burn Injury |
| title_full_unstemmed | The Effects of Ellagic Acid on Experimental Corrosive Esophageal Burn Injury |
| title_short | The Effects of Ellagic Acid on Experimental Corrosive Esophageal Burn Injury |
| title_sort | effects of ellagic acid on experimental corrosive esophageal burn injury |
| topic | ellagic acid antioxidant anti-inflammatory corrosive substance NaOH |
| url | https://www.mdpi.com/1467-3045/46/2/102 |
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