Collagen-Based Ovule Therapy Reduces Inflammation and Improve Cervical Epithelialization in Patients with Fungal, Viral, and Bacterial Cervico-Vaginitis
<i>Background and Objectives</i>: Vulvovaginal infections pose significant health challenges for women, necessitating effective treatment approaches. This retrospective observational study aimed at investigating the efficacy of collagen-based vaginal ovules therapy, specifically Plurigin...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/8/1490 |
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| author | Nicoletta De Rosa Fabrizia Santangelo Celestino Todisco Fabiana Dequerquis Claudio Santangelo |
| author_facet | Nicoletta De Rosa Fabrizia Santangelo Celestino Todisco Fabiana Dequerquis Claudio Santangelo |
| author_sort | Nicoletta De Rosa |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Vulvovaginal infections pose significant health challenges for women, necessitating effective treatment approaches. This retrospective observational study aimed at investigating the efficacy of collagen-based vaginal ovules therapy, specifically Plurigin Ovules, in restoring cervical epithelialization and reducing inflammation in mycotic, viral, and bacterial cervico-vaginitis. <i>Materials and Methods</i>: A total of 398 women with cervico-vaginitis were included in the study, categorized into three groups: bacterial cervico-vaginitis (Group A), viral cervico-vaginitis (Group B), and fungal cervico-vaginitis (Group C). Participants received vaginal therapy with Plurigin Ovules for three months. Vaginal health parameters were assessed at baseline (T0) and after six months (T1) using various diagnostic tests and analyzed with appropriate statistical tests. <i>Results</i>: Significant improvement in cervico-vaginitis was observed in all three groups. At T1, 87.7% patients of Group A, 66.7% of Group B, and 71.5% of Group C achieved infection resolution (all <i>p</i> < 0.05). Positive colposcopy results decreased across all groups (<i>p</i> < 0.001). Positive vaginal swabs and altered vaginal pH decreased in group A and C (<i>p</i> < 0.001). Positive HPV tests decreased in Group B (<i>p</i> < 0.001). Positive Pap tests and clinical examinations decreased significantly across all groups (<i>p</i> < 0.001). The odds ratios were calculated to reveal the significant associations between these diagnostic outcomes. The therapy was well-tolerated, and no major adverse events were reported. <i>Conclusion</i>: Plurigin Ovules exhibited promising therapeutic outcomes in the three cervico-vaginitis conditions studied. Bacterial cervico-vaginitis showed the most significant improvement, followed by fungal and viral cervico-vaginitis. These findings emphasize the potential of Plurigin Ovules as an effective therapeutic option for cervico-vaginal inflammation and infection, highlighting its role in promoting re-epithelialization and reducing inflammatory processes in the cervix and vagina. |
| first_indexed | 2024-03-10T23:45:38Z |
| format | Article |
| id | doaj.art-775f71bb4be4437481930f8b63ef7ddc |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T23:45:38Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-775f71bb4be4437481930f8b63ef7ddc2023-11-19T02:07:09ZengMDPI AGMedicina1010-660X1648-91442023-08-01598149010.3390/medicina59081490Collagen-Based Ovule Therapy Reduces Inflammation and Improve Cervical Epithelialization in Patients with Fungal, Viral, and Bacterial Cervico-VaginitisNicoletta De Rosa0Fabrizia Santangelo1Celestino Todisco2Fabiana Dequerquis3Claudio Santangelo4Ginecology and Obstetric Department, Pio XI Hospital, 20832 Monza-Brianza, ItalyHospital of National Relevance “A. Cardarelli”, 80113 Naples, ItalyASL Napoli 3 Sud, 80059 Torre del Greco, ItalyHospital of National Relevance “A. Cardarelli”, 80113 Naples, ItalyHospital of National Relevance “A. Cardarelli”, 80113 Naples, Italy<i>Background and Objectives</i>: Vulvovaginal infections pose significant health challenges for women, necessitating effective treatment approaches. This retrospective observational study aimed at investigating the efficacy of collagen-based vaginal ovules therapy, specifically Plurigin Ovules, in restoring cervical epithelialization and reducing inflammation in mycotic, viral, and bacterial cervico-vaginitis. <i>Materials and Methods</i>: A total of 398 women with cervico-vaginitis were included in the study, categorized into three groups: bacterial cervico-vaginitis (Group A), viral cervico-vaginitis (Group B), and fungal cervico-vaginitis (Group C). Participants received vaginal therapy with Plurigin Ovules for three months. Vaginal health parameters were assessed at baseline (T0) and after six months (T1) using various diagnostic tests and analyzed with appropriate statistical tests. <i>Results</i>: Significant improvement in cervico-vaginitis was observed in all three groups. At T1, 87.7% patients of Group A, 66.7% of Group B, and 71.5% of Group C achieved infection resolution (all <i>p</i> < 0.05). Positive colposcopy results decreased across all groups (<i>p</i> < 0.001). Positive vaginal swabs and altered vaginal pH decreased in group A and C (<i>p</i> < 0.001). Positive HPV tests decreased in Group B (<i>p</i> < 0.001). Positive Pap tests and clinical examinations decreased significantly across all groups (<i>p</i> < 0.001). The odds ratios were calculated to reveal the significant associations between these diagnostic outcomes. The therapy was well-tolerated, and no major adverse events were reported. <i>Conclusion</i>: Plurigin Ovules exhibited promising therapeutic outcomes in the three cervico-vaginitis conditions studied. Bacterial cervico-vaginitis showed the most significant improvement, followed by fungal and viral cervico-vaginitis. These findings emphasize the potential of Plurigin Ovules as an effective therapeutic option for cervico-vaginal inflammation and infection, highlighting its role in promoting re-epithelialization and reducing inflammatory processes in the cervix and vagina.https://www.mdpi.com/1648-9144/59/8/1490vulvovaginal infectionscervico-vaginitiscervical epithelializationvaginal microbiotahuman papilloma virus |
| spellingShingle | Nicoletta De Rosa Fabrizia Santangelo Celestino Todisco Fabiana Dequerquis Claudio Santangelo Collagen-Based Ovule Therapy Reduces Inflammation and Improve Cervical Epithelialization in Patients with Fungal, Viral, and Bacterial Cervico-Vaginitis Medicina vulvovaginal infections cervico-vaginitis cervical epithelialization vaginal microbiota human papilloma virus |
| title | Collagen-Based Ovule Therapy Reduces Inflammation and Improve Cervical Epithelialization in Patients with Fungal, Viral, and Bacterial Cervico-Vaginitis |
| title_full | Collagen-Based Ovule Therapy Reduces Inflammation and Improve Cervical Epithelialization in Patients with Fungal, Viral, and Bacterial Cervico-Vaginitis |
| title_fullStr | Collagen-Based Ovule Therapy Reduces Inflammation and Improve Cervical Epithelialization in Patients with Fungal, Viral, and Bacterial Cervico-Vaginitis |
| title_full_unstemmed | Collagen-Based Ovule Therapy Reduces Inflammation and Improve Cervical Epithelialization in Patients with Fungal, Viral, and Bacterial Cervico-Vaginitis |
| title_short | Collagen-Based Ovule Therapy Reduces Inflammation and Improve Cervical Epithelialization in Patients with Fungal, Viral, and Bacterial Cervico-Vaginitis |
| title_sort | collagen based ovule therapy reduces inflammation and improve cervical epithelialization in patients with fungal viral and bacterial cervico vaginitis |
| topic | vulvovaginal infections cervico-vaginitis cervical epithelialization vaginal microbiota human papilloma virus |
| url | https://www.mdpi.com/1648-9144/59/8/1490 |
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