Gypenoside Protects against Myocardial Ischemia-Reperfusion Injury by Inhibiting Cardiomyocytes Apoptosis via Inhibition of CHOP Pathway and Activation of PI3K/Akt Pathway In Vivo and In Vitro

Gypenoside Protects against Myocardial Ischemia-Reperfusion Injury by Inhibiting Cardiomyocytes Apoptosis via Inhibition of CHOP Pathway and Activation of PI3K/Akt Pathway In Vivo and In Vitro

Background/Aims: Ischemia-reperfusion (I/R) injury is believed to be the major cause for detriments in coronary heart diseases, but few effective therapies for prevention or treatment of I/R injury are available. Gypenoside (GP) is the predominant effective component of Gynostemma pentaphyllum and p...

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Bibliographic Details
Main Authors: Haijie Yu, Haishan Zhang, Weihua Zhao, Liang Guo, Xueyuan Li, Yang Li, Xingang Zhang, Yingxian Sun
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Akt
Apoptosis
Endoplasmic reticulum stress
Gypenoside
Ischemia-reperfusion injury
Cardiomyocytes
Online Access:http://www.karger.com/Article/FullText/445611

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