Calcium signaling around Mitochondria Associated Membranes (MAMs)
<p>Abstract</p> <p>Calcium (Ca<sup>2+</sup>) homeostasis is fundamental for cell metabolism, proliferation, differentiation, and cell death. Elevation in intracellular Ca<sup>2+ </sup>concentration is dependent either on Ca<sup>2+ </sup>influx fr...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-09-01
|
| Series: | Cell Communication and Signaling |
| Online Access: | http://www.biosignaling.com/content/9/1/19 |
| _version_ | 1811266831484190720 |
|---|---|
| author | Rimessi Alessandro Poletti Federica Missiroli Sonia Marchi Saverio Giorgi Carlotta De Marchi Elena Bonora Massimo Bononi Angela Agnoletto Chiara Suski Jan M Patergnani Simone Duszynski Jerzy Wieckowski Mariusz R Pinton Paolo |
| author_facet | Rimessi Alessandro Poletti Federica Missiroli Sonia Marchi Saverio Giorgi Carlotta De Marchi Elena Bonora Massimo Bononi Angela Agnoletto Chiara Suski Jan M Patergnani Simone Duszynski Jerzy Wieckowski Mariusz R Pinton Paolo |
| author_sort | Rimessi Alessandro |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Calcium (Ca<sup>2+</sup>) homeostasis is fundamental for cell metabolism, proliferation, differentiation, and cell death. Elevation in intracellular Ca<sup>2+ </sup>concentration is dependent either on Ca<sup>2+ </sup>influx from the extracellular space through the plasma membrane, or on Ca<sup>2+ </sup>release from intracellular Ca<sup>2+ </sup>stores, such as the endoplasmic/sarcoplasmic reticulum (ER/SR). Mitochondria are also major components of calcium signalling, capable of modulating both the amplitude and the spatio-temporal patterns of Ca<sup>2+ </sup>signals. Recent studies revealed zones of close contact between the ER and mitochondria called MAMs (Mitochondria Associated Membranes) crucial for a correct communication between the two organelles, including the selective transmission of physiological and pathological Ca<sup>2+ </sup>signals from the ER to mitochondria. In this review, we summarize the most up-to-date findings on the modulation of intracellular Ca<sup>2+ </sup>release and Ca<sup>2+ </sup>uptake mechanisms. We also explore the tight interplay between ER- and mitochondria-mediated Ca<sup>2+ </sup>signalling, covering the structural and molecular properties of the zones of close contact between these two networks.</p> |
| first_indexed | 2024-04-12T20:50:19Z |
| format | Article |
| id | doaj.art-776273b249ed4da1aafe143ebe4ca250 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-04-12T20:50:19Z |
| publishDate | 2011-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-776273b249ed4da1aafe143ebe4ca2502022-12-22T03:17:09ZengBMCCell Communication and Signaling1478-811X2011-09-01911910.1186/1478-811X-9-19Calcium signaling around Mitochondria Associated Membranes (MAMs)Rimessi AlessandroPoletti FedericaMissiroli SoniaMarchi SaverioGiorgi CarlottaDe Marchi ElenaBonora MassimoBononi AngelaAgnoletto ChiaraSuski Jan MPatergnani SimoneDuszynski JerzyWieckowski Mariusz RPinton Paolo<p>Abstract</p> <p>Calcium (Ca<sup>2+</sup>) homeostasis is fundamental for cell metabolism, proliferation, differentiation, and cell death. Elevation in intracellular Ca<sup>2+ </sup>concentration is dependent either on Ca<sup>2+ </sup>influx from the extracellular space through the plasma membrane, or on Ca<sup>2+ </sup>release from intracellular Ca<sup>2+ </sup>stores, such as the endoplasmic/sarcoplasmic reticulum (ER/SR). Mitochondria are also major components of calcium signalling, capable of modulating both the amplitude and the spatio-temporal patterns of Ca<sup>2+ </sup>signals. Recent studies revealed zones of close contact between the ER and mitochondria called MAMs (Mitochondria Associated Membranes) crucial for a correct communication between the two organelles, including the selective transmission of physiological and pathological Ca<sup>2+ </sup>signals from the ER to mitochondria. In this review, we summarize the most up-to-date findings on the modulation of intracellular Ca<sup>2+ </sup>release and Ca<sup>2+ </sup>uptake mechanisms. We also explore the tight interplay between ER- and mitochondria-mediated Ca<sup>2+ </sup>signalling, covering the structural and molecular properties of the zones of close contact between these two networks.</p>http://www.biosignaling.com/content/9/1/19 |
| spellingShingle | Rimessi Alessandro Poletti Federica Missiroli Sonia Marchi Saverio Giorgi Carlotta De Marchi Elena Bonora Massimo Bononi Angela Agnoletto Chiara Suski Jan M Patergnani Simone Duszynski Jerzy Wieckowski Mariusz R Pinton Paolo Calcium signaling around Mitochondria Associated Membranes (MAMs) Cell Communication and Signaling |
| title | Calcium signaling around Mitochondria Associated Membranes (MAMs) |
| title_full | Calcium signaling around Mitochondria Associated Membranes (MAMs) |
| title_fullStr | Calcium signaling around Mitochondria Associated Membranes (MAMs) |
| title_full_unstemmed | Calcium signaling around Mitochondria Associated Membranes (MAMs) |
| title_short | Calcium signaling around Mitochondria Associated Membranes (MAMs) |
| title_sort | calcium signaling around mitochondria associated membranes mams |
| url | http://www.biosignaling.com/content/9/1/19 |
| work_keys_str_mv | AT rimessialessandro calciumsignalingaroundmitochondriaassociatedmembranesmams AT polettifederica calciumsignalingaroundmitochondriaassociatedmembranesmams AT missirolisonia calciumsignalingaroundmitochondriaassociatedmembranesmams AT marchisaverio calciumsignalingaroundmitochondriaassociatedmembranesmams AT giorgicarlotta calciumsignalingaroundmitochondriaassociatedmembranesmams AT demarchielena calciumsignalingaroundmitochondriaassociatedmembranesmams AT bonoramassimo calciumsignalingaroundmitochondriaassociatedmembranesmams AT bononiangela calciumsignalingaroundmitochondriaassociatedmembranesmams AT agnolettochiara calciumsignalingaroundmitochondriaassociatedmembranesmams AT suskijanm calciumsignalingaroundmitochondriaassociatedmembranesmams AT patergnanisimone calciumsignalingaroundmitochondriaassociatedmembranesmams AT duszynskijerzy calciumsignalingaroundmitochondriaassociatedmembranesmams AT wieckowskimariuszr calciumsignalingaroundmitochondriaassociatedmembranesmams AT pintonpaolo calciumsignalingaroundmitochondriaassociatedmembranesmams |