Antimicrobial Fe2O3-CuO-P2O5 glasses
Abstract Glasses with high antimicrobial efficacy were developed in the Fe2O3-CuO-P2O5 ternary system to mitigate fomite-mediated transmission of infectious diseases in high-risk settings such as hospitals, daycares, and nursing homes. Binary CuO-P2O5 glasses were not durable enough for use as high...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-44743-x |
| _version_ | 1797560048898015232 |
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| author | Alexandra L. Mitchell Sung Hoon Lee David J. McEnroe Eric L. Null Daniel A. Sternquist Kathryn A. Hufziger Brian J. Rice Alex Scrimshire Paul A. Bingham Timothy M. Gross |
| author_facet | Alexandra L. Mitchell Sung Hoon Lee David J. McEnroe Eric L. Null Daniel A. Sternquist Kathryn A. Hufziger Brian J. Rice Alex Scrimshire Paul A. Bingham Timothy M. Gross |
| author_sort | Alexandra L. Mitchell |
| collection | DOAJ |
| description | Abstract Glasses with high antimicrobial efficacy were developed in the Fe2O3-CuO-P2O5 ternary system to mitigate fomite-mediated transmission of infectious diseases in high-risk settings such as hospitals, daycares, and nursing homes. Binary CuO-P2O5 glasses were not durable enough for use as high touch point articles, so Fe2O3 was added to the compositions to increase the chemical durability. The amount of Cu leachate decreased by at least 3 orders of magnitude when Fe2O3 was increased from 0 to 13.1 mol%. At the highest Fe2O3 contents and corresponding highest durability, the glass was no longer able to pass a test of antimicrobial efficacy with < 3 log kill compared to > 5 log kill for all other compositions. Ab-initio molecular dynamics simulations showed increasing bridging oxygen species at the expense of non-bridging oxygen species with the increase in Fe2O3 content, showing that the glasses exhibited increased chemical durability because they were more interconnected and structurally bound. Experimental results with glasses at fixed CuO and decreasing Fe2O3 confirmed that Fe2O3 content (not CuO) controlled the Cu release rate and, thus, the antimicrobial efficacy of the glasses. The significance of the oxidation state of the leached Cu was overwhelmed by the importance of the amount of Cu leachate. |
| first_indexed | 2024-03-10T17:53:52Z |
| format | Article |
| id | doaj.art-77627ca4df674a53ae6eca0b1cc4189d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T17:53:52Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-77627ca4df674a53ae6eca0b1cc4189d2023-11-20T09:15:59ZengNature PortfolioScientific Reports2045-23222023-10-0113111110.1038/s41598-023-44743-xAntimicrobial Fe2O3-CuO-P2O5 glassesAlexandra L. Mitchell0Sung Hoon Lee1David J. McEnroe2Eric L. Null3Daniel A. Sternquist4Kathryn A. Hufziger5Brian J. Rice6Alex Scrimshire7Paul A. Bingham8Timothy M. Gross9Corning IncorporatedCorning Technology Center Korea, Corning Precision Materials Co., Ltd.Corning IncorporatedCorning IncorporatedCorning IncorporatedCorning IncorporatedCorning IncorporatedMaterials and Engineering Research Institute, Sheffield Hallam UniversityMaterials and Engineering Research Institute, Sheffield Hallam UniversityCorning IncorporatedAbstract Glasses with high antimicrobial efficacy were developed in the Fe2O3-CuO-P2O5 ternary system to mitigate fomite-mediated transmission of infectious diseases in high-risk settings such as hospitals, daycares, and nursing homes. Binary CuO-P2O5 glasses were not durable enough for use as high touch point articles, so Fe2O3 was added to the compositions to increase the chemical durability. The amount of Cu leachate decreased by at least 3 orders of magnitude when Fe2O3 was increased from 0 to 13.1 mol%. At the highest Fe2O3 contents and corresponding highest durability, the glass was no longer able to pass a test of antimicrobial efficacy with < 3 log kill compared to > 5 log kill for all other compositions. Ab-initio molecular dynamics simulations showed increasing bridging oxygen species at the expense of non-bridging oxygen species with the increase in Fe2O3 content, showing that the glasses exhibited increased chemical durability because they were more interconnected and structurally bound. Experimental results with glasses at fixed CuO and decreasing Fe2O3 confirmed that Fe2O3 content (not CuO) controlled the Cu release rate and, thus, the antimicrobial efficacy of the glasses. The significance of the oxidation state of the leached Cu was overwhelmed by the importance of the amount of Cu leachate.https://doi.org/10.1038/s41598-023-44743-x |
| spellingShingle | Alexandra L. Mitchell Sung Hoon Lee David J. McEnroe Eric L. Null Daniel A. Sternquist Kathryn A. Hufziger Brian J. Rice Alex Scrimshire Paul A. Bingham Timothy M. Gross Antimicrobial Fe2O3-CuO-P2O5 glasses Scientific Reports |
| title | Antimicrobial Fe2O3-CuO-P2O5 glasses |
| title_full | Antimicrobial Fe2O3-CuO-P2O5 glasses |
| title_fullStr | Antimicrobial Fe2O3-CuO-P2O5 glasses |
| title_full_unstemmed | Antimicrobial Fe2O3-CuO-P2O5 glasses |
| title_short | Antimicrobial Fe2O3-CuO-P2O5 glasses |
| title_sort | antimicrobial fe2o3 cuo p2o5 glasses |
| url | https://doi.org/10.1038/s41598-023-44743-x |
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