Dietary branched-chain amino acids intake, glycemic markers, metabolic profile, and anthropometric features in a community-based sample of overweight and obese adults
Abstract Background Existing research provides conflicting evidence regarding the relationship between estimated branched-chain amino acid (BCAA) intake and metabolic, glycemic markers, and anthropometric characteristics. This research seeks to examine the association between estimated dietary BCAA...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-023-01459-3 |
| _version_ | 1797452313537806336 |
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| author | Ensiye Soleimani Fariborz Rashnoo Mahdieh Abbasalizad Farhangi Babak Hosseini Faria Jafarzadeh Amir Shakarami Yoones Sadabadi |
| author_facet | Ensiye Soleimani Fariborz Rashnoo Mahdieh Abbasalizad Farhangi Babak Hosseini Faria Jafarzadeh Amir Shakarami Yoones Sadabadi |
| author_sort | Ensiye Soleimani |
| collection | DOAJ |
| description | Abstract Background Existing research provides conflicting evidence regarding the relationship between estimated branched-chain amino acid (BCAA) intake and metabolic, glycemic markers, and anthropometric characteristics. This research seeks to examine the association between estimated dietary BCAA consumption and glycemic, and metabolic markers, as well as anthropometric parameters in adults classified as overweight or obese. Methods In this cross-sectional analysis, we gathered data from 465 overweight and obese individuals aged between 18 and 37 years. To evaluate dietary data, we employed the food frequency questionnaire, and the BCAA content in foods was determined via the United States Department of Agriculture website. We utilized ELISA kits to measure fasting blood glucose (FBS) and lipid profile markers, and additionally calculated low-density lipoprotein (LDL) and insulin sensitivity markers. We assessed sociodemographic status, physical activity (PA), and anthropometric attributes through a method recognized as both valid and reliable. For statistical analysis, we conducted analyses of covariance (ANCOVA), making adjustments for variables including sex, PA, age, energy, and body mass index (BMI). Results Upon adjusting for confounders, those in the highest tertiles of BCAA intake exhibited an increase in weight, BMI, waist circumference (WC), waist-to-hip ratio (WHR), and fat-free mass (FFM). Conversely, they demonstrated reduced fat mass (FM) (%) and FM (kg) compared to their counterparts in the lowest tertiles (P < 0.05). Additionally, there was a noted association between greater estimated BCAA intake and reduced LDL levels. Nonetheless, our findings did not reveal a significant relationship between dietary BCAA and glycemic indices. Conclusions From our findings, an increased estimated intake of BCAA seems to correlate with diminished serum LDL concentrations. To gain a more comprehensive understanding of this association, it is imperative that further experimental and longitudinal studies be conducted. |
| first_indexed | 2024-03-09T15:07:20Z |
| format | Article |
| id | doaj.art-7763508a7564473182efccabba90cc70 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-03-09T15:07:20Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-7763508a7564473182efccabba90cc702023-11-26T13:35:03ZengBMCBMC Endocrine Disorders1472-68232023-09-0123111010.1186/s12902-023-01459-3Dietary branched-chain amino acids intake, glycemic markers, metabolic profile, and anthropometric features in a community-based sample of overweight and obese adultsEnsiye Soleimani0Fariborz Rashnoo1Mahdieh Abbasalizad Farhangi2Babak Hosseini3Faria Jafarzadeh4Amir Shakarami5Yoones Sadabadi6Tabriz Health Services Management Research Center, Tabriz University of Medical SciencesDepartment of General and Minimally Invasive surgery, Loghman Hakim Hospital, Shahid Beheshti University of Medical SciencesTabriz Health Services Management Research Center, Tabriz University of Medical SciencesDepartment of Surgery, School of Medicine, Laparoscopy Research Center, Shiraz University of Medical SciencesAssistant Professor of Endocrinology & Metabolism, Department of Internal Medicine, School of Medicine, North Khorasan University of Medical SciencesDepartment of Cardiovascular Medicine, Assistant Professor of Cardiology, Lorestan University of Medical SciencesFaculty of Dentistry, Shahed UniversityAbstract Background Existing research provides conflicting evidence regarding the relationship between estimated branched-chain amino acid (BCAA) intake and metabolic, glycemic markers, and anthropometric characteristics. This research seeks to examine the association between estimated dietary BCAA consumption and glycemic, and metabolic markers, as well as anthropometric parameters in adults classified as overweight or obese. Methods In this cross-sectional analysis, we gathered data from 465 overweight and obese individuals aged between 18 and 37 years. To evaluate dietary data, we employed the food frequency questionnaire, and the BCAA content in foods was determined via the United States Department of Agriculture website. We utilized ELISA kits to measure fasting blood glucose (FBS) and lipid profile markers, and additionally calculated low-density lipoprotein (LDL) and insulin sensitivity markers. We assessed sociodemographic status, physical activity (PA), and anthropometric attributes through a method recognized as both valid and reliable. For statistical analysis, we conducted analyses of covariance (ANCOVA), making adjustments for variables including sex, PA, age, energy, and body mass index (BMI). Results Upon adjusting for confounders, those in the highest tertiles of BCAA intake exhibited an increase in weight, BMI, waist circumference (WC), waist-to-hip ratio (WHR), and fat-free mass (FFM). Conversely, they demonstrated reduced fat mass (FM) (%) and FM (kg) compared to their counterparts in the lowest tertiles (P < 0.05). Additionally, there was a noted association between greater estimated BCAA intake and reduced LDL levels. Nonetheless, our findings did not reveal a significant relationship between dietary BCAA and glycemic indices. Conclusions From our findings, an increased estimated intake of BCAA seems to correlate with diminished serum LDL concentrations. To gain a more comprehensive understanding of this association, it is imperative that further experimental and longitudinal studies be conducted.https://doi.org/10.1186/s12902-023-01459-3BCAAMetabolic and glycemic markersAnthropometric measurementsLDL |
| spellingShingle | Ensiye Soleimani Fariborz Rashnoo Mahdieh Abbasalizad Farhangi Babak Hosseini Faria Jafarzadeh Amir Shakarami Yoones Sadabadi Dietary branched-chain amino acids intake, glycemic markers, metabolic profile, and anthropometric features in a community-based sample of overweight and obese adults BMC Endocrine Disorders BCAA Metabolic and glycemic markers Anthropometric measurements LDL |
| title | Dietary branched-chain amino acids intake, glycemic markers, metabolic profile, and anthropometric features in a community-based sample of overweight and obese adults |
| title_full | Dietary branched-chain amino acids intake, glycemic markers, metabolic profile, and anthropometric features in a community-based sample of overweight and obese adults |
| title_fullStr | Dietary branched-chain amino acids intake, glycemic markers, metabolic profile, and anthropometric features in a community-based sample of overweight and obese adults |
| title_full_unstemmed | Dietary branched-chain amino acids intake, glycemic markers, metabolic profile, and anthropometric features in a community-based sample of overweight and obese adults |
| title_short | Dietary branched-chain amino acids intake, glycemic markers, metabolic profile, and anthropometric features in a community-based sample of overweight and obese adults |
| title_sort | dietary branched chain amino acids intake glycemic markers metabolic profile and anthropometric features in a community based sample of overweight and obese adults |
| topic | BCAA Metabolic and glycemic markers Anthropometric measurements LDL |
| url | https://doi.org/10.1186/s12902-023-01459-3 |
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