Herpes zoster incidence in Germany - an indirect validation study for self-reported disease data from pretest studies of the population-based German National Cohort
Abstract Background Until now, herpes zoster (HZ)-related disease burden in Germany has been estimated based on health insurance data and clinical findings. However, the validity of self-reported HZ is unclear. This study investigated the validity of self-reported herpes zoster (HZ) and its complica...
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| Format: | Article |
| Language: | English |
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BMC
2019-01-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-019-3691-2 |
| _version_ | 1818997387437277184 |
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| author | Mahrrouz Caputo Johannes Horn André Karch Manas K. Akmatov Heiko Becher Bettina Braun Hermann Brenner Stefanie Castell Beate Fischer Guido Giani Kathrin Günther Barbara Hoffmann Karl-Heinz Jöckel Thomas Keil Birgit Klüppelholz Lilian Krist Michael F. Leitzmann Wolfgang Lieb Jakob Linseisen Christa Meisinger Susanne Moebus Nadia Obi Tobias Pischon Sabine Schipf Börge Schmidt Claudia Sievers Astrid Steinbrecher Henry Völzke Rafael Mikolajczyk |
| author_facet | Mahrrouz Caputo Johannes Horn André Karch Manas K. Akmatov Heiko Becher Bettina Braun Hermann Brenner Stefanie Castell Beate Fischer Guido Giani Kathrin Günther Barbara Hoffmann Karl-Heinz Jöckel Thomas Keil Birgit Klüppelholz Lilian Krist Michael F. Leitzmann Wolfgang Lieb Jakob Linseisen Christa Meisinger Susanne Moebus Nadia Obi Tobias Pischon Sabine Schipf Börge Schmidt Claudia Sievers Astrid Steinbrecher Henry Völzke Rafael Mikolajczyk |
| author_sort | Mahrrouz Caputo |
| collection | DOAJ |
| description | Abstract Background Until now, herpes zoster (HZ)-related disease burden in Germany has been estimated based on health insurance data and clinical findings. However, the validity of self-reported HZ is unclear. This study investigated the validity of self-reported herpes zoster (HZ) and its complication postherpetic neuralgia (PHN) using data from the pretest studies of the German National Cohort (GNC) in comparison with estimates based on health insurance data. Methods Data of 4751 participants aged between 20 and 69 years from two pretest studies of the GNC carried out in 2011 and 2012 were used. Based on self-reports of physician-diagnosed HZ and PHN, age- and sex-specific HZ incidence rates and PHN proportions were estimated. For comparison, estimates based on statutory health insurance data from the German population were considered. Results Eleven percent (95%-CI, 10.4 to 12.3, n = 539) of the participants reported at least one HZ episode in their lifetime. Our estimated age-specific HZ incidence rates were lower than previous estimates based on statutory health insurance data. The PHN proportion in participants older than 50 years was 5.9% (1.9 to 13.9%), which was in line with estimates based on health insurance data. Conclusion As age- and sex-specific patterns were comparable with that in health insurance data, self-reported diagnosis of HZ seems to be a valid instrument for overall disease trends. Possible reasons for observed differences in incidence rates are recall bias in self-reported data or overestimation in health insurance data. |
| first_indexed | 2024-12-20T21:44:49Z |
| format | Article |
| id | doaj.art-7763842f46e14d79aac66fd852748306 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-20T21:44:49Z |
| publishDate | 2019-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-7763842f46e14d79aac66fd8527483062022-12-21T19:25:42ZengBMCBMC Infectious Diseases1471-23342019-01-011911810.1186/s12879-019-3691-2Herpes zoster incidence in Germany - an indirect validation study for self-reported disease data from pretest studies of the population-based German National CohortMahrrouz Caputo0Johannes Horn1André Karch2Manas K. Akmatov3Heiko Becher4Bettina Braun5Hermann Brenner6Stefanie Castell7Beate Fischer8Guido Giani9Kathrin Günther10Barbara Hoffmann11Karl-Heinz Jöckel12Thomas Keil13Birgit Klüppelholz14Lilian Krist15Michael F. Leitzmann16Wolfgang Lieb17Jakob Linseisen18Christa Meisinger19Susanne Moebus20Nadia Obi21Tobias Pischon22Sabine Schipf23Börge Schmidt24Claudia Sievers25Astrid Steinbrecher26Henry Völzke27Rafael Mikolajczyk28Department of Epidemiology, Helmholtz Centre for Infection ResearchInstitute for Medical Epidemiology, Biometry, and Informatics (IMEBI), Medical Faculty of the Martin Luther University Halle-WittenbergDepartment of Epidemiology, Helmholtz Centre for Infection ResearchDepartment of Epidemiology, Helmholtz Centre for Infection ResearchInstitute of Public Health, University Hospital HeidelbergInstitute for Epidemiology and Social Medicine, University of MünsterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)Department of Epidemiology, Helmholtz Centre for Infection ResearchDepartment of Epidemiology and Preventive Medicine, University RegensburgGerman Diabetes Center (DDZ), Leibniz Research for DiabetesLeibniz Institute for Prevention Research and Epidemiology – BIPSInstitute for Occupational, Social and Environmental Medicine, Heinrich-Heine-University of DüsseldorfInstitute of Medical Informatics, Biometry and Epidemiology, University Hospital EssenInstitute for Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin BerlinGerman Diabetes Center (DDZ), Leibniz Research for DiabetesInstitute for Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin BerlinDepartment of Epidemiology and Preventive Medicine, University RegensburgInstitute of Epidemiology, Christian-Albrechts-University KielHelmholtz Zentrum Munich, German Research Center for Environmental Health, Institute of Epidemiology IIHelmholtz Zentrum Munich, German Research Center for Environmental Health, Institute of Epidemiology IICentre of Urban Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, University Hospital EssenDepartment of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-EppendorfMolecular Epidemiology Research Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC)Institute for Community Medicine, University Medicine Greifswald, University Medicine GreifswaldInstitute of Medical Informatics, Biometry and Epidemiology, University Hospital EssenDepartment of Epidemiology, Helmholtz Centre for Infection ResearchMolecular Epidemiology Research Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC)Institute for Community Medicine, University Medicine Greifswald, University Medicine GreifswaldInstitute for Medical Epidemiology, Biometry, and Informatics (IMEBI), Medical Faculty of the Martin Luther University Halle-WittenbergAbstract Background Until now, herpes zoster (HZ)-related disease burden in Germany has been estimated based on health insurance data and clinical findings. However, the validity of self-reported HZ is unclear. This study investigated the validity of self-reported herpes zoster (HZ) and its complication postherpetic neuralgia (PHN) using data from the pretest studies of the German National Cohort (GNC) in comparison with estimates based on health insurance data. Methods Data of 4751 participants aged between 20 and 69 years from two pretest studies of the GNC carried out in 2011 and 2012 were used. Based on self-reports of physician-diagnosed HZ and PHN, age- and sex-specific HZ incidence rates and PHN proportions were estimated. For comparison, estimates based on statutory health insurance data from the German population were considered. Results Eleven percent (95%-CI, 10.4 to 12.3, n = 539) of the participants reported at least one HZ episode in their lifetime. Our estimated age-specific HZ incidence rates were lower than previous estimates based on statutory health insurance data. The PHN proportion in participants older than 50 years was 5.9% (1.9 to 13.9%), which was in line with estimates based on health insurance data. Conclusion As age- and sex-specific patterns were comparable with that in health insurance data, self-reported diagnosis of HZ seems to be a valid instrument for overall disease trends. Possible reasons for observed differences in incidence rates are recall bias in self-reported data or overestimation in health insurance data.http://link.springer.com/article/10.1186/s12879-019-3691-2German National CohortIncidenceSelf-reportsValidityHerpes zosterPostherpetic neuralgia |
| spellingShingle | Mahrrouz Caputo Johannes Horn André Karch Manas K. Akmatov Heiko Becher Bettina Braun Hermann Brenner Stefanie Castell Beate Fischer Guido Giani Kathrin Günther Barbara Hoffmann Karl-Heinz Jöckel Thomas Keil Birgit Klüppelholz Lilian Krist Michael F. Leitzmann Wolfgang Lieb Jakob Linseisen Christa Meisinger Susanne Moebus Nadia Obi Tobias Pischon Sabine Schipf Börge Schmidt Claudia Sievers Astrid Steinbrecher Henry Völzke Rafael Mikolajczyk Herpes zoster incidence in Germany - an indirect validation study for self-reported disease data from pretest studies of the population-based German National Cohort BMC Infectious Diseases German National Cohort Incidence Self-reports Validity Herpes zoster Postherpetic neuralgia |
| title | Herpes zoster incidence in Germany - an indirect validation study for self-reported disease data from pretest studies of the population-based German National Cohort |
| title_full | Herpes zoster incidence in Germany - an indirect validation study for self-reported disease data from pretest studies of the population-based German National Cohort |
| title_fullStr | Herpes zoster incidence in Germany - an indirect validation study for self-reported disease data from pretest studies of the population-based German National Cohort |
| title_full_unstemmed | Herpes zoster incidence in Germany - an indirect validation study for self-reported disease data from pretest studies of the population-based German National Cohort |
| title_short | Herpes zoster incidence in Germany - an indirect validation study for self-reported disease data from pretest studies of the population-based German National Cohort |
| title_sort | herpes zoster incidence in germany an indirect validation study for self reported disease data from pretest studies of the population based german national cohort |
| topic | German National Cohort Incidence Self-reports Validity Herpes zoster Postherpetic neuralgia |
| url | http://link.springer.com/article/10.1186/s12879-019-3691-2 |
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