Assessment of retrospective collection of EQ-5D-5L in a US COVID-19 population
Abstract Background It is imperative to evaluate health related quality of life (HRQoL) pre-COVID-19, but there is currently no evidence of the retrospective application of the EuroQol 5-Dimension, 5 level version (EQ-5D-5L) for COVID-19 studies. Methods Symptomatic patients with SARS-CoV-2 at CVS H...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Health and Quality of Life Outcomes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12955-023-02187-x |
| _version_ | 1797556300977012736 |
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| author | Xiaowu Sun Manuela Di Fusco Laura Puzniak Henriette Coetzer Joann M. Zamparo Ying P. Tabak Joseph C. Cappelleri |
| author_facet | Xiaowu Sun Manuela Di Fusco Laura Puzniak Henriette Coetzer Joann M. Zamparo Ying P. Tabak Joseph C. Cappelleri |
| author_sort | Xiaowu Sun |
| collection | DOAJ |
| description | Abstract Background It is imperative to evaluate health related quality of life (HRQoL) pre-COVID-19, but there is currently no evidence of the retrospective application of the EuroQol 5-Dimension, 5 level version (EQ-5D-5L) for COVID-19 studies. Methods Symptomatic patients with SARS-CoV-2 at CVS Health US test sites were recruited between 01/31/2022-04/30/2022. Consented participants completed the EQ-5D-5L questionnaire twice: a modified version where all the questions were past tense to retrospectively assess pre-COVID-19 baseline QoL, and the standard version in present tense to assess current HRQoL. Duncan’s new multiple range test was adopted for post analysis of variance pairwise comparisons of EQ visual analog scale (EQ VAS) means between problem levels for each of 5 domains. A linear mixed model was applied to check whether the relationship between EQ VAS and utility index (UI) was consistent pre-COVID-19 and during COVID-19. Matching-adjusted indirect comparison was used to compare pre-COVID-19 UI and EQ VAS scores with those of the US population. Lastly, Cohen’s d was used to quantify the magnitude of difference in means between two groups. Results Of 676 participants, 10.2% were age 65 or more years old, 73.2% female and 71.9% white. Diabetes was reported by 4.7% participants and hypertension by 11.2%. The estimated coefficient for the interaction of UI-by-retrospective collection indicator (0 = standard prospective collection, 1 = retrospective for pre-COVID-19), -4.2 (SE: 3.2), P = 0.197, indicates that retrospective collection does not significantly alter the relationship between EQ VAS and UI. After adjusting for age, gender, diabetes, hypertension, and percent of mobility problems, the predicted means of pre-COVID-19 baseline EQ VAS and UI were 84.6 and 0.866, respectively. Both means were close to published US population norms (80.4 and 0.851) compared to those observed (87.4 and 0.924). After adjusting for age, gender, diabetes, and hypertension, the calculated ES between pre-COVID-19 and COVID-19 for UI and EQ VAS were 0.15 and 0.39, respectively. Without retrospectively collected EQ-5D-5L, using US population norms tended to underestimate the impact of COVID-19 on HRQoL. Conclusion At a group level the retrospectively collected pre-COVID-19 EQ-5D-5L is adequate and makes it possible to directly evaluate the impact of COVID-19 on HRQoL. ( ClinicalTrials.gov NCT05160636) |
| first_indexed | 2024-03-10T16:59:57Z |
| format | Article |
| id | doaj.art-7764af8f72c345e0a53e331c64b14cfc |
| institution | Directory Open Access Journal |
| issn | 1477-7525 |
| language | English |
| last_indexed | 2024-03-10T16:59:57Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Health and Quality of Life Outcomes |
| spelling | doaj.art-7764af8f72c345e0a53e331c64b14cfc2023-11-20T11:00:04ZengBMCHealth and Quality of Life Outcomes1477-75252023-09-012111710.1186/s12955-023-02187-xAssessment of retrospective collection of EQ-5D-5L in a US COVID-19 populationXiaowu Sun0Manuela Di Fusco1Laura Puzniak2Henriette Coetzer3Joann M. Zamparo4Ying P. Tabak5Joseph C. Cappelleri6Clinical Trial Services, CVS HealthPfizer Inc, Health Economics and Outcomes ResearchPfizer Inc, MDSCA VaccinesClinical Trial Services, CVS HealthPfizer IncClinical Trial Services, CVS HealthPfizer Inc, Statistical Research and Data Science CenterAbstract Background It is imperative to evaluate health related quality of life (HRQoL) pre-COVID-19, but there is currently no evidence of the retrospective application of the EuroQol 5-Dimension, 5 level version (EQ-5D-5L) for COVID-19 studies. Methods Symptomatic patients with SARS-CoV-2 at CVS Health US test sites were recruited between 01/31/2022-04/30/2022. Consented participants completed the EQ-5D-5L questionnaire twice: a modified version where all the questions were past tense to retrospectively assess pre-COVID-19 baseline QoL, and the standard version in present tense to assess current HRQoL. Duncan’s new multiple range test was adopted for post analysis of variance pairwise comparisons of EQ visual analog scale (EQ VAS) means between problem levels for each of 5 domains. A linear mixed model was applied to check whether the relationship between EQ VAS and utility index (UI) was consistent pre-COVID-19 and during COVID-19. Matching-adjusted indirect comparison was used to compare pre-COVID-19 UI and EQ VAS scores with those of the US population. Lastly, Cohen’s d was used to quantify the magnitude of difference in means between two groups. Results Of 676 participants, 10.2% were age 65 or more years old, 73.2% female and 71.9% white. Diabetes was reported by 4.7% participants and hypertension by 11.2%. The estimated coefficient for the interaction of UI-by-retrospective collection indicator (0 = standard prospective collection, 1 = retrospective for pre-COVID-19), -4.2 (SE: 3.2), P = 0.197, indicates that retrospective collection does not significantly alter the relationship between EQ VAS and UI. After adjusting for age, gender, diabetes, hypertension, and percent of mobility problems, the predicted means of pre-COVID-19 baseline EQ VAS and UI were 84.6 and 0.866, respectively. Both means were close to published US population norms (80.4 and 0.851) compared to those observed (87.4 and 0.924). After adjusting for age, gender, diabetes, and hypertension, the calculated ES between pre-COVID-19 and COVID-19 for UI and EQ VAS were 0.15 and 0.39, respectively. Without retrospectively collected EQ-5D-5L, using US population norms tended to underestimate the impact of COVID-19 on HRQoL. Conclusion At a group level the retrospectively collected pre-COVID-19 EQ-5D-5L is adequate and makes it possible to directly evaluate the impact of COVID-19 on HRQoL. ( ClinicalTrials.gov NCT05160636)https://doi.org/10.1186/s12955-023-02187-xCOVID-19SARS-CoV-2Health-related quality of lifeRetrospective collection |
| spellingShingle | Xiaowu Sun Manuela Di Fusco Laura Puzniak Henriette Coetzer Joann M. Zamparo Ying P. Tabak Joseph C. Cappelleri Assessment of retrospective collection of EQ-5D-5L in a US COVID-19 population Health and Quality of Life Outcomes COVID-19 SARS-CoV-2 Health-related quality of life Retrospective collection |
| title | Assessment of retrospective collection of EQ-5D-5L in a US COVID-19 population |
| title_full | Assessment of retrospective collection of EQ-5D-5L in a US COVID-19 population |
| title_fullStr | Assessment of retrospective collection of EQ-5D-5L in a US COVID-19 population |
| title_full_unstemmed | Assessment of retrospective collection of EQ-5D-5L in a US COVID-19 population |
| title_short | Assessment of retrospective collection of EQ-5D-5L in a US COVID-19 population |
| title_sort | assessment of retrospective collection of eq 5d 5l in a us covid 19 population |
| topic | COVID-19 SARS-CoV-2 Health-related quality of life Retrospective collection |
| url | https://doi.org/10.1186/s12955-023-02187-x |
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