Targeting Lysosomes in Cancer as Promising Strategy to Overcome Chemoresistance—A Mini Review
To date, cancer remains a worldwide leading cause of death, with a still rising incidence. This is essentially caused by the fact, that despite the abundance of therapeutic targets and treatment strategies, insufficient response and multidrug resistance frequently occur. Underlying mechanisms are mu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-07-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.01156/full |
| _version_ | 1831658427266367488 |
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| author | Franz Geisslinger Martin Müller Angelika M. Vollmar Karin Bartel |
| author_facet | Franz Geisslinger Martin Müller Angelika M. Vollmar Karin Bartel |
| author_sort | Franz Geisslinger |
| collection | DOAJ |
| description | To date, cancer remains a worldwide leading cause of death, with a still rising incidence. This is essentially caused by the fact, that despite the abundance of therapeutic targets and treatment strategies, insufficient response and multidrug resistance frequently occur. Underlying mechanisms are multifaceted and extensively studied. In recent research, it became evident, that the lysosome is of importance in drug resistance phenotypes. While it has long been considered just as cellular waste bag, it is now widely known that lysosomes play an important role in important cellular signaling processes and are in the focus of cancer research. In that regard lysosomes are now considered as so-called “drug safe-houses” in which chemotherapeutics are trapped passively by diffusion or actively by lysosomal P-glycoprotein activity, which prevents them from reaching their intracellular targets. Furthermore, alterations in lysosome to nucleus signaling by the transcription factor EB (TFEB)—mTORC1 axis are implicated in development of chemoresistance. The identification of lysosomes as essential players in drug resistance has introduced novel strategies to overcome chemoresistance and led to innovate therapeutic approaches. This mini review gives an overview of the current state of research on the role of lysosomes in chemoresistance, summarizing underlying mechanisms and treatment strategies and critically discussing open questions and drawbacks. |
| first_indexed | 2024-12-19T17:44:14Z |
| format | Article |
| id | doaj.art-7764b20afa5b48eb8edccddad63d336f |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-19T17:44:14Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-7764b20afa5b48eb8edccddad63d336f2022-12-21T20:12:07ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-07-011010.3389/fonc.2020.01156549433Targeting Lysosomes in Cancer as Promising Strategy to Overcome Chemoresistance—A Mini ReviewFranz GeisslingerMartin MüllerAngelika M. VollmarKarin BartelTo date, cancer remains a worldwide leading cause of death, with a still rising incidence. This is essentially caused by the fact, that despite the abundance of therapeutic targets and treatment strategies, insufficient response and multidrug resistance frequently occur. Underlying mechanisms are multifaceted and extensively studied. In recent research, it became evident, that the lysosome is of importance in drug resistance phenotypes. While it has long been considered just as cellular waste bag, it is now widely known that lysosomes play an important role in important cellular signaling processes and are in the focus of cancer research. In that regard lysosomes are now considered as so-called “drug safe-houses” in which chemotherapeutics are trapped passively by diffusion or actively by lysosomal P-glycoprotein activity, which prevents them from reaching their intracellular targets. Furthermore, alterations in lysosome to nucleus signaling by the transcription factor EB (TFEB)—mTORC1 axis are implicated in development of chemoresistance. The identification of lysosomes as essential players in drug resistance has introduced novel strategies to overcome chemoresistance and led to innovate therapeutic approaches. This mini review gives an overview of the current state of research on the role of lysosomes in chemoresistance, summarizing underlying mechanisms and treatment strategies and critically discussing open questions and drawbacks.https://www.frontiersin.org/article/10.3389/fonc.2020.01156/fullchemoresistancecytostaticscancerlysosomeTFEB |
| spellingShingle | Franz Geisslinger Martin Müller Angelika M. Vollmar Karin Bartel Targeting Lysosomes in Cancer as Promising Strategy to Overcome Chemoresistance—A Mini Review Frontiers in Oncology chemoresistance cytostatics cancer lysosome TFEB |
| title | Targeting Lysosomes in Cancer as Promising Strategy to Overcome Chemoresistance—A Mini Review |
| title_full | Targeting Lysosomes in Cancer as Promising Strategy to Overcome Chemoresistance—A Mini Review |
| title_fullStr | Targeting Lysosomes in Cancer as Promising Strategy to Overcome Chemoresistance—A Mini Review |
| title_full_unstemmed | Targeting Lysosomes in Cancer as Promising Strategy to Overcome Chemoresistance—A Mini Review |
| title_short | Targeting Lysosomes in Cancer as Promising Strategy to Overcome Chemoresistance—A Mini Review |
| title_sort | targeting lysosomes in cancer as promising strategy to overcome chemoresistance a mini review |
| topic | chemoresistance cytostatics cancer lysosome TFEB |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.01156/full |
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