Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care
We examined the association of elevated concentration of total homocysteine (tHcy) with the severity of depression in patients diagnosed with depression and comorbid chronic medical conditions in rural primary care settings in Karnataka. Participants were included from the control arm of a cluster-r...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | International Journal of Noncommunicable Diseases |
| Subjects: | |
| Online Access: | http://www.ijncd.org/article.asp?issn=2468-8827;year=2022;volume=7;issue=2;spage=95;epage=97;aulast=Srinivasan |
| _version_ | 1811313174249472000 |
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| author | Krishnamachari Srinivasan Luke Joshua Salazar Elsa Heylen Maria L Ekstrand |
| author_facet | Krishnamachari Srinivasan Luke Joshua Salazar Elsa Heylen Maria L Ekstrand |
| author_sort | Krishnamachari Srinivasan |
| collection | DOAJ |
| description | We examined the association of elevated concentration of total homocysteine (tHcy) with the severity of depression in patients diagnosed with depression and comorbid chronic medical conditions in rural primary care settings in Karnataka. Participants were included from the control arm of a cluster-randomized controlled trial designed to evaluate the effects of using a collaborative care model to integrate screening and treatment of primary health center patients. tHcy was assayed at baseline, and depression severity scores were assessed using the Patient Health Questionnaire (PHQ-9) 6 months later. There was no difference in the mean PHQ-9 score between those with (mean PHQ = 7.4) and without (mean PHQ = 7.6) elevated tHcy levels (P = 0.67). |
| first_indexed | 2024-04-13T10:49:12Z |
| format | Article |
| id | doaj.art-7765149ee62e4de58da7b2c968c60435 |
| institution | Directory Open Access Journal |
| issn | 2468-8827 2468-8835 |
| language | English |
| last_indexed | 2024-04-13T10:49:12Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Noncommunicable Diseases |
| spelling | doaj.art-7765149ee62e4de58da7b2c968c604352022-12-22T02:49:42ZengWolters Kluwer Medknow PublicationsInternational Journal of Noncommunicable Diseases2468-88272468-88352022-01-0172959710.4103/jncd.jncd_18_22Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary careKrishnamachari SrinivasanLuke Joshua SalazarElsa HeylenMaria L EkstrandWe examined the association of elevated concentration of total homocysteine (tHcy) with the severity of depression in patients diagnosed with depression and comorbid chronic medical conditions in rural primary care settings in Karnataka. Participants were included from the control arm of a cluster-randomized controlled trial designed to evaluate the effects of using a collaborative care model to integrate screening and treatment of primary health center patients. tHcy was assayed at baseline, and depression severity scores were assessed using the Patient Health Questionnaire (PHQ-9) 6 months later. There was no difference in the mean PHQ-9 score between those with (mean PHQ = 7.4) and without (mean PHQ = 7.6) elevated tHcy levels (P = 0.67).http://www.ijncd.org/article.asp?issn=2468-8827;year=2022;volume=7;issue=2;spage=95;epage=97;aulast=Srinivasandepressionhomocysteineprimary health care |
| spellingShingle | Krishnamachari Srinivasan Luke Joshua Salazar Elsa Heylen Maria L Ekstrand Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care International Journal of Noncommunicable Diseases depression homocysteine primary health care |
| title | Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care |
| title_full | Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care |
| title_fullStr | Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care |
| title_full_unstemmed | Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care |
| title_short | Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care |
| title_sort | elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care |
| topic | depression homocysteine primary health care |
| url | http://www.ijncd.org/article.asp?issn=2468-8827;year=2022;volume=7;issue=2;spage=95;epage=97;aulast=Srinivasan |
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